Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients von Herbst, Roy S., Soria, Jean-Charles, Kowanetz, Marcin, Fine, Gregg D., Hamid, Omid, Gordon, Michael S., Sosman, Jeffery A., McDermott, David F., Powderly, John D., Gettinger, Scott N., Kohrt, Holbrook E. K., Horn, Leora, Lawrence, Donald P., Rost, Sandra, Leabman, Maya, Xiao, Yuanyuan, Mokatrin, Ahmad, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Chen, Daniel S., Hodi, F. Stephen

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Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates von Yeung, Yik Andy, Leabman, Maya K, Marvin, Jonathan S, Qiu, Julia, Adams, Camellia W, Lien, Samantha, Starovasnik, Melissa A, Lowman, Henry B

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Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor von Deng, Rong, Bumbaca, Daniela, Pastuskovas, Cinthia V, Boswell, C Andrew, West, David, Cowan, Kyra J, Chiu, Henry, McBride, Jacqueline, Johnson, Clarissa, Xin, Yan, Koeppen, Hartmut, Leabman, Maya, Iyer, Suhasini

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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin von Chen, Ying, Li, Shuanglian, Brown, Chaline, Cheatham, Stephen, Castro, Richard A, Leabman, Maya K, Urban, Thomas J, Chen, Ligong, Yee, Sook Wah, Choi, Ji Ha, Huang, Yong, Brett, Claire M, Burchard, Esteban G, Giacomini, Kathleen M

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Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys von Leabman, Maya K, Meng, Y Gloria, Kelley, Robert F, DeForge, Laura E, Cowan, Kyra J, Iyer, Suhasini

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Evolutionary Conservation Predicts Function of Variants of the Human Organic Cation Transporter, OCT1 von Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., DeYoung, Joseph, Carlson, Elaine, Ferrin, Thomas E., Herskowitz, Ira, Giacomini, Kathleen M., Pharmacogenetics of Membrane Transporters Investigators

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Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants von Fujita, Tomoe, Urban, Thomas J., Leabman, Maya K., Fujita, Kazumi, Giacomini, Kathleen M.

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A phase 1 study to evaluate the safety and LDL cholesterol–lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 von Baruch, Amos, Luca, Diana, Kahn, Robert S., Cowan, Kyra J., Leabman, Maya, Budha, Nageshwar R., Chiu, Cecilia P.C., Wu, Yan, Kirchhofer, Daniel, Peterson, Andrew, Davis Jr, John C., Tingley, Whittemore G.

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Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1) von Fujita, Tomoe, Brown, Chaline, Carlson, Elaine J, Taylor, Travis, de la Cruz, Melanie, Johns, Susan J, Stryke, Doug, Kawamoto, Michiko, Fujita, Kazumi, Castro, Richard, Chen, Chung-Wen, Lin, Emil T, Brett, Claire M, Burchard, Esteban Gonzalez, Ferrin, Thomas E, Huang, Conrad C, Leabman, Maya K, Giacomini, Kathleen M

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Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters von Dresser, Mark J., Leabman, Maya Kaushal, Giacomini, Kathleen M.

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Critical role of bioanalytical strategies in investigation of clinical PK observations, a Phase I case study von Peng, Kun, Xu, Keyang, Liu, Luna, Hendricks, Robert, Delarosa, Reginald, Erickson, Rich, Budha, Nageshwar, Leabman, Maya, Song, An, Kaur, Surinder, Fischer, Saloumeh K

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Functional genomics of membrane transporters in human populations von Urban, Thomas J, Sebro, Ronnie, Hurowitz, Evan H, Leabman, Maya K, Badagnani, Ilaria, Lagpacan, Leah L, Risch, Neil, Giacomini, Kathleen M

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P815: HIGH VALENCY OF IGM‐2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING von Hart, Kevin C., Santos, Daniel, Pandya, Deepal, Deng, Rong, LI, Keyu, Guan, Yinghui, Hernandez, Genevive, Manley, Thomas, Leabman, Maya K., Hinton, Paul R., Liu, Liqin, Sinclair, Angus M., Candia, Albert F., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

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Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade von Lin, Wei Yu, Gong, Qian, Seshasayee, Dhaya, Lin, Zhonghua, Ou, Qinglin, Ye, Shiming, Suto, Eric, Shu, Jean, Pun Lee, Wyne, Lee, Ching-Wei V., Fuh, Germaine, Leabman, Maya, Iyer, Suhasini, Howell, Kathy, Gelzleichter, Thomas, Beyer, Joseph, Danilenko, Dimitry, Yeh, Sherry, DeForge, Laura E., Ebens, Allen, Thompson, Jeffrey S., Ambrose, Christine, Balazs, Mercedesz, Starovasnik, Melissa A., Martin, Flavius

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Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints von Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., de la Cruz, Melanie, Johns, Susan J., Stryke, Doug, Kawamoto, Michiko, Urban, Thomas J., Kroetz, Deanna L., Ferrin, Thomas E., Clark, Andrew G., Risch, Neil, Herskowitz, Ira, Giacomini, Kathleen M., Pharmacogenetics of Membrane Transporters Investigators

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Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2) von DRESSER, Mark J, GUANGQING XIAO, LEABMAN, Maya K, GRAY, Andrew T, GIACOMINI, Kathleen M

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Pharmacodynamics and Biomarker Correlates of Imvotamab (IGM-2323), the First-in-Class CD20xCD3 Bispecific IgM Antibody with Dual Mechanisms of Action, in Patients with Advanced B C... von Hernandez, Genevive H., So, John, Logronio, Kathryn A., Kotturi, Maya F., Kim, Won Seog, Armand, Philippe, Cheah, Chan Y., Gopal, Ajay K., Flinn, Ian W., Gregory, Gareth P., Matasar, Matthew J., Nastoupil, Loretta J., Diefenbach, Catherine S., Yoon, Sung-Soo, Ku, Matthew, Qazi, Ibrahim, Leabman, Maya K., Sison, Iris, Keyt, Bruce A., Takimoto, Chris H., Manley, Thomas J., Budde, Elizabeth L.

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Preliminary Results of a Phase 1 Dose Escalation Study of the First-in-Class IgM Based Bispecific Antibody Igm-2323 (anti-CD20 x anti-CD3) in Patients with Advanced B-Cell Malignan... von Budde, Elizabeth, Gopal, Ajay K., Flinn, Ian W., Nastoupil, Loretta J., Gordon, Michael S., Pang, Ching-Fai, Keyt, Bruce, Carroll, Steve, Leabman, Maya, Hernandez, Genevive, Sison, Iris, Chen, Daniel, Godfrey, Wayne, Armand, Philippe

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Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity von Wang, Beatrice T., Kothambawala, Tasnim, Hart, Kevin C., Chen, Xingjie, Desbois, Melanie, Calhoun, Susan E., Yakkundi, Poonam, Rosete, Rodnie A., Cao, Yuan, Cha, Katie, Matthew, Thomas J., Wang, Ling, Hinton, Paul R., Leabman, Maya K., Hernandez, Genevive, Kotturi, Maya F., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

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A Phase 1 Dose Escalation Study of Igm-2323, a Novel Anti-CD20 x Anti-CD3 IgM T Cell Engager (TCE) in Patients with Advanced B-Cell Malignancies von Budde, Elizabeth, Gopal, Ajay K, Kim, Won Seog, Flinn, Ian W., Cheah, Chan Yoon Y., Nastoupil, Loretta, Matasar, Matthew J., Diefenbach, Catherine S., Gregory, Gareth P, Qazi, Ibrahim, Pang, Ching-Fai, Leabman, Maya, Hernandez, Genevive, Sison, Iris, Keyt, Bruce A., Chen, Daniel, Armand, Philippe

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