SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis von Zhu, Qingwei, Le Scolan, Erwan, Jahchan, Nadine, Ji, Xiaodan, Xu, Albert, Luo, Kunxin

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Ski regulates Hippo and TAZ signaling to suppress breast cancer progression von Rashidian, Juliet, Le Scolan, Erwan, Ji, Xiaodan, Zhu, Qingwei, Mulvihill, Melinda M, Nomura, Daniel, Luo, Kunxin

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1064 Characterization of preclinical anti-tumor and pharmacodynamic activity in response to conditionally active IFNa with or without checkpoint blockade von Povinelli, Benjamin, Kaur, Kamaljeet, Berezhnoy, Alexey, Wang, Hsin, Lapuyade, Nicole, LePage, Carol, Winter, Michael, Vasiljeva, Olga, Paidhungat, Madan, Rangan, Vangipuram, Scolan, Erwan Le, Boustany, Leila, Belvin, Marcia, Daniel, Dylan

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Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression von Javelaud, Delphine, van Kempen, Leon, Alexaki, Vasileia I, Le Scolan, Erwan, Luo, Kunxin, Mauviel, Alain

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Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression von Le Scolan, Erwan, Pchejetski, Dimitri, Banno, Yoshiko, Denis, Nicole, Mayeux, Patrick, Vainchenker, William, Levade, Thierry, Moreau-Gachelin, Françoise

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706 Conditional cytokine therapeutics for tumor-selective biological activity: preclinical characterization of a dual-masked IFN-a2b von Berezhnoy, Alexey, Wang, Hsin, Cai, Na, Assi, Hikmat, Lapuyade, Nicole, Paidhungat, Madan, Wong, Kenneth, Krimm, Michael, Dunn, Robert, Daniel, Dylan, Belvin, Marcia, Scolan, Erwan Le

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SCNP identifies CLL donor subgroups by profiling functional immune signaling in the context of immune modulatory receptor expression von Le Scolan, Erwan, Fanton, Christie, Conroy, Andy, Tai, Albert, Tan, Nguyen, Louie, Brent, Evensen, Erik, Hawtin, Rachael

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Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking von Leprince, Corinne, Le Scolan, Erwan, Meunier, Brigitte, Fraisier, Vincent, Brandon, Nathalie, De Gunzburg, Jean, Camonis, Jacques

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Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts von LE SCOLAN, Erwan, WENDLING, Francoise, BARNACHE, Stéphane, DENIS, Nicole, TULLIEZ, Micheline, VAINCHENKER, William, MOREAU-GACHELIN, Francoise

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Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity von Mulvihill, Melinda M., Benjamin, Daniel I., Ji, Xiaodan, Le Scolan, Erwan, Louie, Sharon M., Shieh, Alice, Green, McKenna, Narasimhalu, Tara, Morris, Patrick J., Luo, Kunxin, Nomura, Daniel K.

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Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation von Le Scolan, Erwan, Zhu, Qingwei, Wang, Long, Bandyopadhyay, Abhik, Javelaud, Delphine, Mauviel, Alain, Sun, LuZhe, Luo, Kunxin

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Abstract 3202: A probody drug conjugate targeting CD166 (ALCAM) enhances preclinical antitumor activity of a probody therapeutic targeting PD-1 von Scolan, Erwan Le, Tse, Tiffany, Krimm, Michael, Garner, Will, Assi, Hikmat, Razo, Jennifer, Wong, Laurie, Wong, Kenneth, Singson, Victoria, Leong, Jennifer, Diep, Linnea, Richardson, Jennifer, Schleyer, Siew, Daniel, Dylan, Belvin, Marcia, Kavanaugh, Michael

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Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth von Argast, Gretchen M., Cancilla, Belinda, Cattaruzza, Fiore, Yeung, Pete, Lahmy, Reyhaneh, Scolan, Erwan Le, Harris, Rose, Brunner, Alayne, Wang, Min, Axelrod, Fumiko, Monteon, Jorge, Elechko, Jennifer, Lam, Andrew, Xie, MingHong, Lowe, Earth Light, O'Young, Gilbert, Gurney, Austin, Kapoun, Ann M.

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Abstract 5627: Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition von Argast, Gretchen M., Cancilla, Belinda, Cattaruzza, Fiore, Yeung, Pete, Scolan, Erwan le, Harris, Rose, Lahmy, Reyhaneh, Brunner, Alayne, Wang, Min, O'Young, Gilbert, Lowe, Earth Light, Axelrod, Fumiko, Monteon, Jorge, Elechko, Jennifer, Lam, Andrew, Xie, MingHong, Gurney, Austin, Lewicki, John, Kapoun, Ann

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Abstract 599: Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types von Cattaruzza, Fiore, Yeung, Pete, Wang, Min, Brunner, Alayne, Scolan, Erwan Le, Cain, Jennifer, Argast, Gretechen, O'Young, Gilbert, Liu, YuWang, Cancilla, Belinda, Gurney, Austin, Hoey, Tim, Lewicki, John, Kapoun, Ann

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1078 Conditionally activatable interferon-alpha 2b improves tolerability and exhibits preferential activity in tumors von Berezhnoy, Alexey, Wang, Hsin, Lapuyade, Nicole, Cai, Na, LePage, Carol, Winter, Michael, Krimm, Michael, Wong, Kenneth, Dunn, Robert, McAlister, Sean, Boustany, Leila, Paidhungat, Madan, Belvin, Marcia, Erwan Le Scolan, Daniel, Dylan

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Abstract 2071: Probody-interferon-alpha 2b combines antitumor activity with improved tolerability von Berezhnoy, Alexey, Wang, Hsin, Lapuyade, Nicole, Cai, Na, LePage, Carol, Winter, Michael B., Ye, Ivan, Lu, Hong, Krimm, Michael, Wong, Ken, Dunn, Robert T., Boustany, Leila, Paidhungat, Madan, Belvin, Marcia, Scolan, Erwan Le, Daniel, Dylan

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Efficient TGF-[beta]/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression von Javelaud, Delphine, van Kempen, Leon, Alexaki, Vasileia I, Le Scolan, Erwan, Luo, Kunxin, Mauviel, Alain

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CNP identifies CLL donor subgroups by profiling functional immune signaling in the context of immune modulatory receptor expression von Erwan Le Scolan, Fanton, Christie, Conroy, Andy, Tai, Albert, Nguyen, Tan, Louie, Brent, Evensen, Erik, Hawtin, Rachael

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COMBINED THERAPIES OF ACTIVATABLE IMMUNE CHECKPOINT INHIBITORS AND CONJUGATED ACTIVATABLE ANTIBODIES von Tse, Tiffany, Le Scolan, Erwan, Krimm, Michael A, Garner, Will

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