Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors von Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Bosq, Jacques, Vassal, Gilles, Geoerger, Birgit

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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma von Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

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Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models von Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Pagès, Mélanie, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit

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New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis von Plessier, Alexandre, Le Dret, Ludivine, Varlet, Pascale, Beccaria, Kévin, Lacombe, Joëlle, Mériaux, Sébastien, Geffroy, Françoise, Fiette, Laurence, Flamant, Patricia, Chrétien, Fabrice, Blauwblomme, Thomas, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David

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VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells von Menez, Virginie, Kergrohen, Thomas, Shasha, Tal, Silva-Evangelista, Claudia, Le Dret, Ludivine, Auffret, Lucie, Subecz, Chloé, Lancien, Manon, Ajlil, Yassine, Vilchis, Irma Segoviano, Beccaria, Kévin, Blauwblomme, Thomas, Oberlin, Estelle, Grill, Jacques, Castel, David, Debily, Marie-Anne

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Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes von Castel, David, Philippe, Cathy, Calmon, Raphaël, Le Dret, Ludivine, Truffaux, Nathalène, Boddaert, Nathalie, Pagès, Mélanie, Taylor, Kathryn R., Saulnier, Patrick, Lacroix, Ludovic, Mackay, Alan, Jones, Chris, Sainte-Rose, Christian, Blauwblomme, Thomas, Andreiuolo, Felipe, Puget, Stephanie, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne

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Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies von Abbou, Samuel, Lanvers-Kaminsky, Claudia, Daudigeos-Dubus, Estelle, LE Dret, Ludivine, Laplace-Builhe, Corinne, Molenaar, Jan, Vassal, Gilles, Geoerger, Birgit

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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma von Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

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Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma von Truffaux, Nathalène, Philippe, Cathy, Paulsson, Janna, Andreiuolo, Felipe, Guerrini-Rousseau, Léa, Cornilleau, Gaétan, Le Dret, Ludivine, Richon, Catherine, Lacroix, Ludovic, Puget, Stéphanie, Geoerger, Birgit, Vassal, Gilles, Östman, Arne, Grill, Jacques

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DIPG-56. EXPLORATION OF TUMOR/STROMA INTERACTIONS IN DIPG XENOGRAFT BY SPECIES-SPECIFIC RNA-SEQ DECONVOLUTION INDICATES A ROLE OF MICROGLIA CELL IN DIPG DEVELOPMENT von Merlevede, Jane, Plessier, Alexandre, Felix, Arthur, Philippe, Cathy, Dret, Ludivine Le, Hardy, David, Beccaria, Kevin, Grill, Jacques, Castel, David, Varlet, Pascale, Debily, Marie-Anne

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Systematic identification of suspected anthelmintic benzimidazole metabolites using LC–MS/MS von Majewsky, Marius, Castel, David, Le Dret, Ludivine, Johann, Pascal, Jones, David T., Pfister, Stefan M., Haefeli, Walter E., Burhenne, Jürgen

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Establishment and characterization of new orthotopic and metastatic neuroblastoma models von Daudigeos-Dubus, Estelle, LE Dret, Ludivine, Rouffiac, Valérie, Bawa, Olivia, Leguerney, Ingrid, Opolon, Paule, Vassal, Gilles, Geoerger, Birgit

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Abstract 4537: Geranyloxy-ifosfamide: A pre-activated ifosfamide analogue showing an increased therapeutic index von Skarbek, Charles, Desmaele, Didier, Deroussent, Alain, Lesueur, Lea, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Rivard, Michael, Martens, Thierry, Vassal, Gilles, Couvreur, Patrick, PACI, Angelo

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Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and... von Deroussent, Alain, Skarbek, Charles, Maury, Adeline, Chapuis, Hubert, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Durand, Sylvère, Couvreur, Patrick, Desmaële, Didier, Paci, Angelo

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Abstract 2763: Activity of dasatinib and potential escape mechanisms in diffuse intrinsic pontine glioma (DIPG) models von Truffaux, Nathalene, Dret, Ludivine Le, Puget, Stephanie, Vassal, Gilles, Geoerger, Birgit, Grill, Jacques

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DIPG-21. GENOMIC LANDSCAPE OF THE FIRST 100 TUMORS REGISTERED IN THE BIOLOGICAL MEDICINE FOR DIPG ERADICATION (BIOMEDE) TRIAL von Castel, David, Barret, Emilie, Picot, Stephanie, Plessier, Alexandre, Le Dret, Ludivine, Nysom, Karsten, Huybrechts, Sophie, Capolino, Perrine, Le Deley, Marie-Cecile, Vassal, Gilles, Puget, Stephanie, Varlet, Pascale, Grill, Jacques, Debily, Marie-Anne

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HG-55DEVELOPMENT OF IN VIVO MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) FROM STEREOTACTIC BIOPSIES PERFORMED AT DIAGNOSIS von Plessier, Alexandre, Le Dret, Ludivine, Fiette, Laurence, Mériaux, Sébastien, Beccaria, Kévin, Varlet, Pascale, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David

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Regorafenib antitumor activity alone and in combination with radio or chemotherapy in preclinical models of pediatric solid tumors von Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Villa, Irene, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit

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DIPG-43. CHARACTERIZATION OF THE BLOOD BRAIN BARRIER IN DIPG MURINE MODELS AND EFFECT OF ULTRASOUND ON ITS SPECIFICITIES AND PERMEABILITY TO ASIDNA von BIARD, adam, LE Ludivine, DRET, Marie, DUTREIX, Alexandre, CARPENTIER, Manon, LANCIEN, Alexandre, PELLISSIER, Marie-Anne, Debily, David, CASTEL, Jacques, GRILL, Kevin, BECCARIA

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Erratum: Functionally defined therapeutic targets in diffuse intrinsic pontine glioma von Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

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