Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux von Komulainen, Emilia, Pennicott, Lewis, Le Grand, Darren, Caldecott, Keith W

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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Di... von Grand, Darren Le, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood K, Choudhury, Hedaythul, Collingwood, Stephen P, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Glotin, Anne-Lise, Groot-Kormelink, Paul, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian, Page, Christopher, Pergl-Wilson, Giles, Popa, Mariana Oana, Robinson, Richard, Rowlands, David, Sharp, Tom, Spendiff, Matthew, Stanley, Emily, Steward, Oliver, Taylor, Roger J, Tranter, Pamela, Wagner, Trixie, Watson, Hazel, Williams, Gareth, Wright, Penny, Young, Alice, Sandham, David A

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A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct von Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid, Oliver, Antony W

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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway von Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C., Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F., Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Grand, Darren Le, McCarthy, Clive, O’Connor, Desmond, Owen, Charles, Oza, Mrinalini S., Pilgrim, Gaynor, Press, Nicola E., Sviridenko, Lilya, Whitehead, Lewis

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Development of autotaxin inhibitors: A series of tetrazole cinnamides von Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shrestha, Binesh, Steward, Oliver, Zink, Florence

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Abstract 2907: Targeting the epigenetic regulator KAT2a in cancer von Gunnell, Andrea, Downs, Jessica, Pennicott, Lewis, Osborn, Kay, Grand, Darren Le, Duffell, Katie, Patel, Hitesh, Hudson, Jessica, Booth, Jessica R., Ward, Simon

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Abstract 4210: Screening of kinase focused libraries for the identification of Greatwall inhibitors von Reuillon, Tristan D., Walker, Sarah, Grand, Darren Le, Ward, Simon E., Wahab, Ben, Rajasekaran, Mohan B., Hochegger, Helfrid, Oliver, Antony W.

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Development of autotaxin inhibitors: A series of zinc binding triazoles von Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Brocklehurst, Cara E., Chinn, Colin, Elphick, Lucy, Faller, Michael, Freeman, Mark, Furminger, Vikki, Gasser, Cornelia, Hamadi, Ahmed, Hardaker, Elizabeth, Head, Victoria, Hill, Johan C., Janus, Diana I., Pearce, David, Poulaud, Anne-Sophie, Stanley, Emily, Sviridenko, Lilya

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The Discovery of orally available thrombin inhibitors : Studies towards the optimisation of CGH1668 von Ambler, John, Baker, Emma, Brown, Lyndon, Butler, Paul, Farr, Dave, Dunnet, Karen, Grand, Darren Le, Janus, Diana, Jones, Darryl, Menear, Keith, Mercer, Mark, Smith, Garrick, Talbot, Mark, Tweed, Morris

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The discovery of orally available thrombin inhibitors: Optimisation of the P1 pharmacophore von Ambler, John, Bentley, David, Brown, Lyndon, Dunnet, Karen, Farr, Dave, Janus, Diana, Grand, Darren Le, Menear, Keith, Mercer, Mark, Talbot, Mark, Tweed, Morris, Wathey, Bernard

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Preparation of neplanocin-A from D-ribose and by a chemoenzymic method von HILL, J. M, HUTCHINSON, E. J, LE GRAND, D. M, ROBERTS, S. M, THORPE, A. J, TURNER, N. J

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Pyridine and pyrazine derivative for the treatment of chronic bronchitis von Howsham, Catherine, Baettig, Urs, Budd, Emma, Spiegel, Katrin, Bala, Kamlesh Jagdis, Edwards, Lee, Hughes, Glyn Alan, Le Grand, Darren Mark

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Pet imaging agents von Auberson, Yves, Briard, Emmanuelle, Le Grand, Darren, Oberhauser, Berndt

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PET Imaging Agents von Auberson, Yves, Briard, Emmanuelle, Le Grand, Darren, Oberhauser, Berndt

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PET Imaging agents von Auberson, Yves, Briard, Emmanuelle, Le Grand, Darren, Oberhauser, Berndt

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PET Imaging Agents von Auberson, Yves, Briard, Emmanuelle, Le Grand, Darren, Oberhauser, Berndt

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Enzyme-catalysed hydrolyses of some meso-diesters von COTTERILL, I. C, COX, P. B, SIK, V, WILLIAMS, J. O, DRAKE, A. F, LE GRAND, D. M, HUTCHINSON, E. J, LATOUCHE, R, PETTMAN, R. B, PRYCE, R. J, ROBERTS, S. M, RYBACK, G

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PROTACS FOR TARGETED DEGRADATION OF KAT2A AND KAT2B FOR THE TREATMENT OF CANCER von LE GRAND, Darren, PENNICOTT, Lewis, WARD, Simon

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PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS von TURNER Penelope, BAEK Ki Seon, LE GRAND Darren, REUILLON Tristan, MARAMAI Samuele, WARD Simon, PARK Young Whan, WEST Ryan, CHOI Soongyu, KHOO Ja Heouk

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Autotaxin inhibitors von Furminger Vikki, Stanley Emily, Thomson Christopher, Hughes Owen Rhys, Le Grand Darren Mark

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