Rings in drugs von Taylor, Richard D, MacCoss, Malcolm, Lawson, Alastair D G

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Rings in Clinical Trials and Drugs: Present and Future von Shearer, Jonathan, Castro, Jose L., Lawson, Alastair D. G., MacCoss, Malcolm, Taylor, Richard D.

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Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers von Lawson, Alastair D G, MacCoss, Malcolm, Heer, Jag P

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Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F von Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D. G., Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn

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Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies von Macpherson, Alex, Scott-Tucker, Anthony, Spiliotopoulos, Anastasios, Simpson, Catherine, Staniforth, Justin, Hold, Adam, Snowden, James, Manning, Leah, van den Elsen, Jean, Lawson, Alastair D. G.

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Antibody-enabled small-molecule drug discovery von Lawson, Alastair D. G.

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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF von Lightwood, Daniel J., Munro, Rebecca J., Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S., Schmidt, Antje, Fox, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O’Connell, James, Lawson, Alastair D. G.

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Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery von Taylor, Richard D, MacCoss, Malcolm, Lawson, Alastair D G

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Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition von Adams, Ralph, Bunick, Christopher G., Lawson, Alastair D.G., Gomez, Braulio, Shaw, Stevan

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Phage Display of Bovine Ultralong CDRH3 von Joyce, Callum, Speight, Louise, Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex

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Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance von Carrington, Bruce, Myers, William K., Horanyi, Peter, Calmiano, Mark, Lawson, Alastair D.G.

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Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics von Cossins, Benjamin P, Lawson, Alastair D G

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Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism von Shaw, Daniel J, Waters, Lorna C, Strong, Sarah L, Schulze, Monika-Sarah E. D, Greetham, Gregory M, Towrie, Mike, Parker, Anthony W, Prosser, Christine E, Henry, Alistair J, Lawson, Alastair D. G, Carr, Mark. D, Taylor, Richard J, Hunt, Neil T, Muskett, Frederick W

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The allosteric modulation of complement C5 by knob domain peptides von Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa A., Birtley, James R., Schulze, Monika-Sarah E. D., Crennell, Susan, Robinson, Sarah A., Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H., Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M., Svergun, Dmitri, Lawson, Alastair D. G., van den Elsen, Jean M. H.

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A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers von Heads, James T, Kelm, Sebastian, Tyson, Kerry, Lawson, Alastair D G

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Modular design of bi- and multi-specific knob domain fusions von Kuravsky, Mikhail, Gibbons, Glyn F, Joyce, Callum, Scott-Tucker, Anthony, Macpherson, Alex, Lawson, Alastair D G

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Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability von Heads, James T, Lamb, Richard, Kelm, Sebastian, Adams, Ralph, Elliott, Peter, Tyson, Kerry, Topia, Sarfaraj, West, Shauna, Nan, Ruodan, Turner, Alison, Lawson, Alastair D G

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The Chemical Synthesis of Knob Domain Antibody Fragments von Macpherson, Alex, Birtley, James R, Broadbridge, Robert J, Brady, Kevin, Schulze, Monika-Sarah E. D, Tang, Yalan, Joyce, Callum, Saunders, Kenneth, Bogle, Gregory, Horton, John, Kelm, Sebastian, Taylor, Richard D, Franklin, Richard J, Selby, Matthew D, Laabei, Maisem, Wonfor, Toska, Hold, Adam, Stanley, Phil, Vadysirisack, Douangsone, Shi, Jiye, van den Elsen, Jean, Lawson, Alastair D. G

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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR von Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D, Norman, Tim, Porter, John, Waters, Lorna C, Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H, Fox, 3rd, David, Carr, Mark D, Henry, Alistair, Taylor, Richard, Meier, Beat H, Oschkinat, Hartmut, Lawson, Alastair D

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Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides von Adams, Ralph, Joyce, Callum, Kuravskiy, Mikhail, Harrison, Katriona, Ahdash, Zainab, Balmforth, Matthew, Chia, Kelda, Marceddu, Cinzia, Coates, Matthew, Snowden, James, Goursaud, Emmanuel, Ménochet, Karelle, Elsen, Jean van den, Payne, Richard J., Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex

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