Development of targeted protein degradation therapeutics von Chamberlain, Philip P., Hamann, Lawrence G.

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Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration von Genovino, Julien, Sames, Dalibor, Hamann, Lawrence G., Touré, B. Barry

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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma von Hansen, Joshua D, Correa, Matthew, Nagy, Mark A, Alexander, Matt, Plantevin, Veronique, Grant, Virginia, Whitefield, Brandon, Huang, Dehua, Kercher, Timothy, Harris, Roy, Narla, Rama Krishna, Leisten, Jim, Tang, Yang, Moghaddam, Mehran, Ebinger, Katalin, Piccotti, Joseph, Havens, Courtney G, Cathers, Brian, Carmichael, James, Daniel, Thomas, Vessey, Rupert, Hamann, Lawrence G, Leftheris, Katerina, Mendy, Derek, Baculi, Frans, LeBrun, Laurie A, Khambatta, Gody, Lopez-Girona, Antonia

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Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex von Matyskiela, Mary E., Clayton, Thomas, Zheng, Xinde, Mayne, Christopher, Tran, Eileen, Carpenter, Aaron, Pagarigan, Barbra, McDonald, Joseph, Rolfe, Mark, Hamann, Lawrence G., Lu, Gang, Chamberlain, Philip P.

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SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate von Matyskiela, Mary E., Couto, Suzana, Zheng, Xinde, Lu, Gang, Hui, Julia, Stamp, Katie, Drew, Clifton, Ren, Yan, Wang, Maria, Carpenter, Aaron, Lee, Chung-Wein, Clayton, Thomas, Fang, Wei, Lu, Chin-Chun, Riley, Mariko, Abdubek, Polat, Blease, Kate, Hartke, James, Kumar, Gondi, Vessey, Rupert, Rolfe, Mark, Hamann, Lawrence G., Chamberlain, Philip P.

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Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion von He, Jing, Hamann, Lawrence G., Davies, Huw M. L., Beckwith, Rohan E. J.

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Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins von Page, Claire G, Cooper, Simon J, DeHovitz, Jacob S, Oblinsky, Daniel G, Biegasiewicz, Kyle F, Antropow, Alyssa H, Armbrust, Kurt W, Ellis, J Michael, Hamann, Lawrence G, Horn, Evan J, Oberg, Kevin M, Scholes, Gregory D, Hyster, Todd K

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA) von Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A

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Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2‑Oxaspiro[3.3]heptanes von Murray, Philip R. D, Bussink, Willem M. M, Davies, Geraint H. M, van der Mei, Farid W, Antropow, Alyssa H, Edwards, Jacob T, D’Agostino, Laura Akullian, Ellis, J. Michael, Hamann, Lawrence G, Romanov-Michailidis, Fedor, Knowles, Robert R

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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo von Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J Michael

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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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Sustainable Practices in Medicinal Chemistry: Current State and Future Directions von Bryan, Marian C, Dillon, Barry, Hamann, Lawrence G, Hughes, Gregory J, Kopach, Michael E, Peterson, Emily A, Pourashraf, Mehrnaz, Raheem, Izzat, Richardson, Paul, Richter, Daniel, Sneddon, Helen F

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect von Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G

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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer von Tria, George S, Abrams, Tinya, Baird, Jason, Burks, Heather E, Firestone, Brant, Gaither, L. Alex, Hamann, Lawrence G, He, Guo, Kirby, Christina A, Kim, Sunkyu, Lombardo, Franco, Macchi, Kaitlin J, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Springer, Clayton, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Yu, Bing, Tiong-Yip, Choi-Lai, Peukert, Stefan

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Synthetic strategy: natural products on demand von Hamann, Lawrence G

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Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines von Bissonnette, Noah B, Ellis, J. Michael, Hamann, Lawrence G, Romanov-Michailidis, Fedor

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Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality von Chamberlain, Philip P, D’Agostino, Laura A, Ellis, J. Michael, Hansen, Joshua D, Matyskiela, Mary E, McDonald, Joseph J, Riggs, Jennifer R, Hamann, Lawrence G

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Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of N‑Methyl-5-aryl‑N‑(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Spl... von Axford, Jake, Sung, Moo Je, Manchester, John, Chin, Donovan, Jain, Monish, Shin, Youngah, Dix, Ina, Hamann, Lawrence G, Cheung, Atwood K, Sivasankaran, Rajeev, Briner, Karin, Dales, Natalie A, Hurley, Brian

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Regioselective Synthesis and Slow-Release Suzuki–Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles von Grob, Jonathan E, Nunez, Jill, Dechantsreiter, Michael A, Hamann, Lawrence G

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Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2) von Chen, Young, Whitefield, Brandon, Nevius, Erin, Hill, Mark, DelRosario, Joselyn, Sinitsyna, Nadia, Shanmugasundaram, Veerabahu, Mukherjee, Debarati, Shi, Lihong, Mayne, Christopher Glenn, Rousseau, Anne-Marie, Bernard, Steffen M., Buenviaje, Jennifer, Khambatta, Gody, El Samin, Miriam, Wallace, Michael, Nie, Zhe, Sivakumar, Pallavur, Hamann, Lawrence G., McDonnell, Donald P., D’Agostino, Laura Akullian

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