Heparan sulfate 3-O-sulfation: A rare modification in search of a function von Thacker, Bryan E., Xu, Ding, Lawrence, Roger, Esko, Jeffrey D.

Volltext

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type von Ihse, Elisabet, Yamakado, Hodaka, van Wijk, Xander M., Lawrence, Roger, Esko, Jeffrey D., Masliah, Eliezer

Volltext

Disease-specific non–reducing end carbohydrate biomarkers for mucopolysaccharidoses von Lawrence, Roger, Brown, Jillian R, Al-Mafraji, Kanar, Lamanna, William C, Beitel, James R, Boons, Geert-Jan, Esko, Jeffrey D, Crawford, Brett E

Volltext

Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans von Ortmann, Corinna, Pickhinke, Ute, Exner, Sebastian, Ohlig, Stefanie, Lawrence, Roger, Jboor, Hamodah, Dreier, Rita, Grobe, Kay

Volltext

Hepatic Remnant Lipoprotein Clearance by Heparan Sulfate Proteoglycans and Low-Density Lipoprotein Receptors Depend on Dietary Conditions in Mice von Foley, Erin M., Gordts, Philip L.S.M., Stanford, Kristin I., Gonzales, Jon C., Lawrence, Roger, Stoddard, Nicole, Esko, Jeffrey D.

Volltext

Evolutionary Differences in Glycosaminoglycan Fine Structure Detected by Quantitative Glycan Reductive Isotope Labeling von Lawrence, Roger, Olson, Sara K., Steele, Robert E., Wang, Lianchun, Warrior, Rahul, Cummings, Richard D., Esko, Jeffrey D.

Volltext

Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB von Kan, Shih-hsin, Aoyagi-Scharber, Mika, Le, Steven Q., Vincelette, Jon, Ohmi, Kazuhiro, Bullens, Sherry, Wendt, Daniel J., Christiansen, Terri M., Tiger, Pascale M. N., Brown, Julian R., Lawrence, Roger, Yip, Bryan K., Holtzinger, John, Bagri, Anil, Crippen-Harmon, Danielle, Vondrak, Kristen N., Chen, Zhi, Hague, Chuck M., Woloszynek, Josh C., Cheung, Diana S., Webster, Katherine A., Adintori, Evan G., Lo, Melanie J., Wong, Wesley, Fitzpatrick, Paul A., LeBowitz, Jonathan H., Crawford, Brett E., Bunting, Stuart, Dickson, Patricia I., Neufeld, Elizabeth F.

Volltext

Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling von Gordts, Philip L.S.M., Foley, Erin M., Lawrence, Roger, Sinha, Risha, Lameda-Diaz, Carlos, Deng, Liwen, Nock, Ryan, Glass, Christopher K., Erbilgin, Ayca, Lusis, Aldons J., Witztum, Joseph L., Esko, Jeffrey D.

Volltext

Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses von Cavender, Catlyn, Mangini, Linley, Van Vleet, Jeremy L., Corado, Carley, McCullagh, Emma, Gray-Edwards, Heather L., Martin, Douglas R., Crawford, Brett E., Lawrence, Roger

Volltext

BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pat... von Yogalingam, Gouri, Luu, Amanda R, Prill, Heather, Lo, Melanie J, Yip, Bryan, Holtzinger, John, Christianson, Terri, Aoyagi-Scharber, Mika, Lawrence, Roger, Crawford, Brett E, LeBowitz, Jonathan H

Volltext

Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells von Coppi, Alida, Tewari, Rita, Bishop, Joseph R, Bennett, Brandy L, Lawrence, Roger, Esko, Jeffrey D, Billker, Oliver, Sinnis, Photini

Volltext

Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans von Lawrence, Roger, Lu, Hong, Rosenberg, Robert D, Esko, Jeffrey D, Zhang, Lijuan

Volltext

Surfen, a small molecule antagonist of heparan sulfate von Schuksz, Manuela, Fuster, Mark M, Brown, Jillian R, Crawford, Brett E, Ditto, David P, Lawrence, Roger, Glass, Charles A, Wang, Lianchun, Tor, Yitzhak, Esko, Jeffrey D

Volltext

Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions von Egeland, Martin T., Tarczyluk-Wells, Marta M., Asmar, Melissa M., Adintori, Evan G., Lawrence, Roger, Snella, Elizabeth M., Jens, Jackie K., Crawford, Brett E., Wait, Jill C. M., McCullagh, Emma, Pinkstaff, Jason, Cooper, Jonathan D., Ellinwood, N. Matthew

Volltext

Lacrimal Gland Development and Fgf10-Fgfr2b Signaling Are Controlled by 2-O- and 6-O-sulfated Heparan Sulfate von Qu, Xiuxia, Carbe, Christian, Tao, Chenqi, Powers, Andrea, Lawrence, Roger, van Kuppevelt, Toin H., Cardoso, Wellington V., Grobe, Kay, Esko, Jeffrey D., Zhang, Xin

Volltext

Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice von Kowalewski, Björn, Lamanna, William C, Lawrence, Roger, Damme, Markus, Stroobants, Stijn, Padva, Michael, Kalus, Ina, Frese, Marc-André, Lübke, Torben, Lüllmann-Rauch, Renate, D’Hooge, Rudi, Esko, Jeffrey D, Dierks, Thomas

Volltext

A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac3) von Wijk, Xander M., Lawrence, Roger, Thijssen, Victor L., Broek, Sebastiaan A., Troost, Ran, Scherpenzeel, Monique, Naidu, Natasha, Oosterhof, Arie, Griffioen, Arjan W., Lefeber, Dirk J., Delft, Floris L., Kuppevelt, Toin H.

Volltext

Galactokinase 1 is the source of elevated galactose‐1‐phosphate and cerebrosides are modestly reduced in a mouse model of classic galactosemia von Mangini, Linley, Lawrence, Roger, Lopez, Manuel E., Graham, Timothy C., Bauer, Christopher R., Nguyen, Hang, Su, Cheng, Ramphal, John, Crawford, Brett E., Hartl, Tom A.

Volltext

Dual Roles of the Cardin-Weintraub Motif in Multimeric Sonic Hedgehog von Farshi, Pershang, Ohlig, Stefanie, Pickhinke, Ute, Höing, Susanne, Jochmann, Katja, Lawrence, Roger, Dreier, Rita, Dierker, Tabea, Grobe, Kay

Volltext

Characterization of glycan substrates accumulating in GM1 Gangliosidosis von Lawrence, Roger, Van Vleet, Jeremy L., Mangini, Linley, Harris, Adam, Martin, Nathan, Clark, Wyatt, Chandriani, Sanjay, LeBowitz, Jonathan H., Giugliani, Roberto, d'Azzo, Alessandra, Yogalingam, Gouri, Crawford, Brett E.

Volltext