Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status von Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

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The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency von Bayley, Jean-Pierre, Launonen, Virpi, Tomlinson, Ian P M

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Inherited Susceptibility to Uterine Leiomyomas and Renal Cell Cancer von Launonen, Virpi, Vierimaa, Outi, Kiuru, Maija, Isola, Jorma, Roth, Stina, Pukkala, Eero, Sistonen, Pertti, Herva, Riitta, Aaltonen, Lauri A.

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Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations von Georgitsi, Marianthi, Raitila, Anniina, Karhu, Auli, Tuppurainen, Karoliina, Mäkinen, Markus J, Vierimaa, Outi, Paschke, Ralf, Saeger, Wolfgang, van der Luijt, Rob B, Sane, Timo, Robledo, Mercedes, De Menis, Ernesto, Weil, Robert J, Wasik, Anna, Zielinski, Grzegorz, Lucewicz, Olga, Lubinski, Jan, Launonen, Virpi, Vahteristo, Pia, Aaltonen, Lauri A

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Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma von Saarinen, Silva, Aavikko, Mervi, Aittomäki, Kristiina, Launonen, Virpi, Lehtonen, Rainer, Franssila, Kaarle, Lehtonen, Heli J., Kaasinen, Eevi, Broderick, Peter, Tarkkanen, Jussi, Bain, Barbara J., Bauduer, Frédéric, Ünal, Ali, Swerdlow, Anthony J., Cooke, Rosie, Mäkinen, Markus J., Houlston, Richard, Vahteristo, Pia, Aaltonen, Lauri A.

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Mutations in the circadian gene CLOCK in colorectal cancer von Alhopuro, Pia, Björklund, Mikael, Sammalkorpi, Heli, Turunen, Mikko, Tuupanen, Sari, Biström, Mia, Niittymäki, Iina, Lehtonen, Heli J, Kivioja, Teemu, Launonen, Virpi, Saharinen, Juha, Nousiainen, Kari, Hautaniemi, Sampsa, Nuorva, Kyösti, Mecklin, Jukka-Pekka, Järvinen, Heikki, Orntoft, Torben, Arango, Diego, Lehtonen, Rainer, Karhu, Auli, Taipale, Jussi, Aaltonen, Lauri A

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Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis von ASHRAFIAN, Houman, O'FLAHERTY, Linda, MIRANDA, Melroy, HOWARTH, Kimberley, SHUKLA, Deepa, TROY, Helen, GRIFFITHS, John, SPENCER-DENE, Bradley, YUSUF, Mohammed, VOLPI, Emanuela, MAXWELL, Patrick H, STAMP, Gordon, ADAM, Julie, POULSOM, Richard, PUGH, Christopher W, COSTA, Barbara, BARDELLA, Chiara, FLAVIA DI RENZO, Maria, KOTLIKOFF, Michael I, LAUNONEN, Virpi, AALTONEN, Lauri, EL-BAHRAWY, Mona, TOMLINSON, Ian, STEEPLES, Violetta, POLLARD, Patrick J, CHUNG, Yuen-Li, EAST, Phil, VANHARANTA, Sakari, LEHTONEN, Heli, NYE, Emma, HATIPOGLU, Emine

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Analysis of fumarate hydratase mutations in a population‐based series of early onset uterine leiomyosarcoma patients von Ylisaukko‐oja, Sanna K., Kiuru, Maija, Lehtonen, Heli J., Lehtonen, Rainer, Pukkala, Eero, Arola, Johanna, Launonen, Virpi, Aaltonen, Lauri A.

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Biallelic Inactivation of Fumarate Hydratase ( FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors von Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, Arola, Johanna, Butzow, Ralf, Eng, Charis, Husgafvel-Pursiainen, Kirsti, Isola, Jorma, Järvinen, Heikki, Koivisto, Pasi, Mecklin, Jukka-Pekka, Peltomäki, Päivi, Salovaara, Reijo, Wasenius, Veli-Matti, Karhu, Auli, Launonen, Virpi, Nupponen, Nina N., Aaltonen, Lauri A.

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Unregulated smooth-muscle myosin in human intestinal neoplasia von Alhopuro, Pia, Phichith, Denis, Tuupanen, Sari, Sammalkorpi, Heli, Nybondas, Miranda, Saharinen, Juha, Robinson, James P, Yang, Zhaohui, Chen, Li-Qiong, Orntoft, Torben, Mecklin, Jukka-Pekka, Järvinen, Heikki, Eng, Charis, Moeslein, Gabriela, Shibata, Darryl, Houlston, Richard S, Lucassen, Anneke, Tomlinson, Ian P.M, Launonen, Virpi, Ristimäki, Ari, Arango, Diego, Karhu, Auli, Sweeney, H. Lee, Aaltonen, Lauri A

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Germline Mutations in BMPR1A/ALK3 Cause a Subset of Cases of Juvenile Polyposis Syndrome and of Cowden and Bannayan-Riley-Ruvalcaba Syndromes von Zhou, Xiao-Ping, Woodford-Richens, Kelly, Lehtonen, Rainer, Kurose, Keisuke, Aldred, Micheala, Hampel, Heather, Launonen, Virpi, Virta, Sanno, Pilarski, Robert, Salovaara, Reijo, Bodmer, Walter F., Conrad, Beth A., Dunlop, Malcolm, Hodgson, Shirley V., Iwama, Takeo, Järvinen, Heikki, Kellokumpu, Ilmo, Kim, J.C., Leggett, Barbara, Markie, David, Mecklin, Jukka-Pekka, Neale, Kay, Phillips, Robin, Piris, Juan, Rozen, Paul, Houlston, Richard S., Aaltonen, Lauri A., Tomlinson, Ian P.M., Eng, Charis

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Induction of Cyclooxygenase-2 in a Mouse Model of Peutz-Jeghers Polyposis von Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, Henkemeyer, Mark, Ristimäki, Ari, Aaltonen, Lauri A., Mäkelä, Tomi P.

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Mutations in the human LKB1/STK11 gene von Launonen, Virpi

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Conventional renal cancer in a patient with fumarate hydratase mutation von Lehtonen, Heli J., MSc, Blanco, Ignacio, MD, PhD, Piulats, Jose M., MD, Herva, Riitta, MD, PhD, Launonen, Virpi, PhD, Aaltonen, Lauri A., MD, PhD

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Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: Indications of TSLC1 promoter hypermethylation von Allinen, Minna, Peri, Liisa, Kujala, Sonja, Lahti-Domenici, Jaana, Outila, Kati, Karppinen, Sanna-Maria, Launonen, Virpi, Winqvist, Robert

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MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas von MÄKINEN, Netta, MEHINE, Miika, AAVIKKO, Mervi, KATAINEN, Riku, VIROLAINEN, Elina, BÖHLING, Tom, KOSKI, Taru A, LAUNONEN, Virpi, SJÖBERG, Jari, TAIPALE, Jussi, VAHTERISTO, Pia, AALTONEN, Lauri A, TOLVANEN, Jaana, KAASINEN, Eevi, YILONG LI, LEHTONEN, Heli J, GENTILE, Massimiliano, JIAN YAN, ENGE, Martin, TAIPALE, Minna

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Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays von Kiuru, Anne, Kämäräinen, Meerit, Heinävaara, Sirpa, Pylkäs, Katri, Chapman, Kim, Koivistoinen, Armi, Parviainen, Teuvo, Winqvist, Robert, Kadhim, Munira, Launonen, Virpi, Lindholm, Carita

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Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiatio... von Launonen, Virpi, Sollazzo, Alice, Haghdoost, Siamak, Acheva, Anna, Kämäräinen, Meerit

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Pituitary Adenoma Predisposition Caused by Germline Mutations in the AIP Gene von Vierimaa, Outi, Georgitsi, Marianthi, Lehtonen, Rainer, Vahteristo, Pia, Kokko, Antti, Raitila, Anniina, Tuppurainen, Karoliina, Ebeling, Tapani M.L, Salmela, Pasi I, Paschke, Ralf, Gündogdu, Sadi, De Menis, Ernesto, Mäkinen, Markus J, Launonen, Virpi, Karhu, Auli, Aaltonen, Lauri A

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Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine Neoplasia von Georgitsi, Marianthi, Raitila, Anniina, Karhu, Auli, van der Luijt, Rob B., Aalfs, Cora M., Sane, Timo, Vierimaa, Outi, Mäkinen, Markus J., Tuppurainen, Karoliina, Paschke, Ralph, Gimm, Oliver, Koch, Christian A., Gündogdu, Sadi, Lucassen, Anneke, Tischkowitz, Marc, Izatt, Louise, Aylwin, Simon, Bano, Gul, Hodgson, Shirley, De Menis, Ernesto, Launonen, Virpi, Vahteristo, Pia, Aaltonen, Lauri A.

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