Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice von Eckert, Gunter P., Marx, Stefan, Zotzel, Jens, Silaidos, Carmina, Grewal, Rekha, Reutzel, Martina, Tretzel, Joachim

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Editorial: Advances in the Biology and Medicine of Pain von Latini, Alexandra, Costigan, Michael

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Ischemic Retinopathies: Oxidative Stress and Inflammation von Tahiri, Houda, Omri, Samy, Noueihed, Baraa, Dabouz, Rabah, Rivera, José Carlos, Chemtob, Sylvain

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Editorial: Insights in experimental pharmacology and drug discovery: 2022 von Latini, Alexandra, Uroz, Carmen Peralta, Trostchansky, Andrés

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In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function von Cordova, Fabiano M, Aguiar, Jr, Aderbal S, Peres, Tanara V, Lopes, Mark W, Gonçalves, Filipe M, Remor, Aline P, Lopes, Samantha C, Pilati, Célso, Latini, Alexandra S, Prediger, Rui D S, Erikson, Keith M, Aschner, Michael, Leal, Rodrigo B

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Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway von Latremoliere, Alban, Latini, Alexandra, Andrews, Nick, Cronin, Shane J., Fujita, Masahide, Gorska, Katarzyna, Hovius, Ruud, Romero, Carla, Chuaiphichai, Surawee, Painter, Michio, Miracca, Giulia, Babaniyi, Olusegun, Remor, Aline Pertile, Duong, Kelly, Riva, Priscilla, Barrett, Lee B., Ferreirós, Nerea, Naylor, Alasdair, Penninger, Josef M., Tegeder, Irmgard, Zhong, Jian, Blagg, Julian, Channon, Keith M., Johnsson, Kai, Costigan, Michael, Woolf, Clifford J.

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Resveratrol protects C6 astrocyte cell line against hydrogen peroxide-induced oxidative stress through heme oxygenase 1 von Quincozes-Santos, André, Bobermin, Larissa Daniele, Latini, Alexandra, Wajner, Moacir, Souza, Diogo Onofre, Gonçalves, Carlos-Alberto, Gottfried, Carmem

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Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity von Staats Pires, Ananda, Tan, Vanessa X, Heng, Benjamin, Guillemin, Gilles J, Latini, Alexandra

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Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes von de Paula Martins, Roberta, Ghisoni, Karina, Lim, Chai K., Aguiar, Aderbal Silva, Guillemin, Gilles J., Latini, Alexandra

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Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway von Aguiar, Aderbal Silva, Duzzioni, Marcelo, Remor, Aline Pertile, Tristão, Fabrine Sales Massafera, Matheus, Filipe C., Raisman-Vozari, Rita, Latini, Alexandra, Prediger, Rui Daniel

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The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats von de Carvalho, Cristiane Ribeiro, Lopes, Mark William, Constantino, Leandra C., Hoeller, Alexandre Ademar, de Melo, Hiago Murilo, Guarnieri, Ricardo, Linhares, Marcelo Neves, Bortolotto, Zuner Assis, Prediger, Rui Daniel, Latini, Alexandra, Lin, Katia, Licinio, Julio, Leal, Rodrigo Bainy, Walz, Roger

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Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling von Aguiar, Aderbal S., Castro, Adalberto A., Moreira, Eduardo L., Glaser, Viviane, Santos, Adair R.S., Tasca, Carla I., Latini, Alexandra, Prediger, Rui D.S.

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Editorial: Obesity and diabetes: implications for brain-immunometabolism, volume II von Gaspar, Joana M., Latini, Alexandra, Duarte, João M. N.

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Short-term high-fat diet alters behavior, peripheral metabolism, and brain mitochondrial function in Swiss mice von Machado, Adriano Emanuel, Rezer, Peterson, Mancini, Gianni, Latini, Alexandra, Moreira, Eduardo Luiz G

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Deep Brain Stimulation for Obesity: A Review and Future Directions von Formolo, Douglas A, Gaspar, Joana M, Melo, Hiago M, Eichwald, Tuany, Zepeda, Ramiro Javier, Latini, Alexandra, Okun, Michael S, Walz, Roger

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Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice von Fujita, Masahide, Scheffer, Débora da Luz, Turnes, Bruna Lenfers, Cronin, Shane J. F., Latrémolière, Alban, Costigan, Michael, Woolf, Clifford J., Latini, Alexandra, Andrews, Nick A.

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Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis von Espíndola, Gisele, Scheffer, Débora da Luz, Latini, Alexandra

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Editorial: Obesity and Diabetes: Implications for Brain-Immunometabolism von Gaspar, Joana M, Talbot, Sebastien, Latini, Alexandra

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Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain von Staats Pires, Ananda, Heng, Benjamin, Tan, Vanessa X., Latini, Alexandra, Russo, Marc A., Santarelli, Danielle M., Bailey, Dominic, Wynne, Katie, O’Brien, Jayden A., Guillemin, Gilles J., Austin, Paul J.

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Standardization of exercise intensity and consideration of a dose–response is essential. Commentary on “Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects... von Gronwald, Thomas, de Bem Alves, Ana Cristina, Murillo-Rodríguez, Eric, Latini, Alexandra, Schuette, Juliane, Budde, Henning

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