Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling von Lundquist, Mark R., Storaska, Andrew J., Liu, Ting-Chun, Larsen, Scott D., Evans, Todd, Neubig, Richard R., Jaffrey, Samie R.

Volltext

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells von Chefetz, Ilana, Grimley, Edward, Yang, Kun, Hong, Linda, Vinogradova, Ekaterina V., Suciu, Radu, Kovalenko, Ilya, Karnak, David, Morgan, Cynthia A., Chtcherbinine, Mikhail, Buchman, Cameron, Huddle, Brandt, Barraza, Scott, Morgan, Meredith, Bernstein, Kara A., Yoon, Euisik, Lombard, David B., Bild, Andrea, Mehta, Geeta, Romero, Iris, Chiang, Chun-Yi, Landen, Charles, Cravatt, Benjamin, Hurley, Thomas D., Larsen, Scott D., Buckanovich, Ronald J.

Volltext

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence von Zheng, Huiqing, Colvin, Christopher J, Johnson, Benjamin K, Kirchhoff, Paul D, Wilson, Michael, Jorgensen-Muga, Katriana, Larsen, Scott D, Abramovitch, Robert B

Volltext

Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation von Ma, Yibao, Xu, Yuanxi, Yestrepsky, Bryan D, Sorenson, Roderick J, Chen, Meng, Larsen, Scott D, Sun, Hongmin

Volltext

Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation von Wang, Nan, Qi, Feng, Yu, Haqing, Yestrepsky, Bryan D, Larsen, Scott D, Shi, Honglan, Ji, Juan, Anderson, David W, Li, Hao, Sun, Hongmin

Volltext

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5 von Stoveken, Hannah M., Larsen, Scott D., Smrcka, Alan V., Tall, Gregory G.

Volltext

X‑ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases von Báez-Santos, Yahira M, Barraza, Scott J, Wilson, Michael W, Agius, Michael P, Mielech, Anna M, Davis, Nicole M, Baker, Susan C, Larsen, Scott D, Mesecar, Andrew D

Volltext

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis von Sisson, Thomas H, Ajayi, Iyabode O, Subbotina, Natalya, Dodi, Amos E, Rodansky, Eva S, Chibucos, Lauren N, Kim, Kevin K, Keshamouni, Venkateshwar G, White, Eric S, Zhou, Yong, Higgins, Peter D.R, Larsen, Scott D, Neubig, Richard R, Horowitz, Jeffrey C

Volltext

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy von Huddle, Brandt C, Grimley, Edward, Buchman, Cameron D, Chtcherbinine, Mikhail, Debnath, Bikash, Mehta, Pooja, Yang, Kun, Morgan, Cynthia A, Li, Siwei, Felton, Jeremy, Sun, Duxin, Mehta, Geeta, Neamati, Nouri, Buckanovich, Ronald J, Hurley, Thomas D, Larsen, Scott D

Volltext

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease von Beck, Michael W., Derrick, Jeffrey S., Kerr, Richard A., Oh, Shin Bi, Cho, Woo Jong, Lee, Shin Jung C., Ji, Yonghwan, Han, Jiyeon, Tehrani, Zahra Aliakbar, Suh, Nayoung, Kim, Sujeong, Larsen, Scott D., Kim, Kwang S., Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee

Volltext

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts von Johnson, Laura A, Rodansky, Eva S, Haak, Andrew J, Larsen, Scott D, Neubig, Richard R, Higgins, Peter D R

Volltext

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents von Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.

Volltext

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases von Shayman, James A., Larsen, Scott D.

Volltext

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine mod... von Haak, Andrew J, Tsou, Pei-Suen, Amin, Mohammad A, Ruth, Jeffrey H, Campbell, Phillip, Fox, David A, Khanna, Dinesh, Larsen, Scott D, Neubig, Richard R

Volltext

Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes von Dumas, Megan E., Chen, Geng-Yuan, Kendrick, Nicole D., Xu, George, Larsen, Scott D., Jana, Somnath, Waterson, Alex G., Bauer, Joshua A., Hancock, William, Sulikowski, Gary A., Ohi, Ryoma

Volltext

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis von Yu-Wai-Man, Cynthia, Spencer-Dene, Bradley, Lee, Richard M. H., Hutchings, Kim, Lisabeth, Erika M., Treisman, Richard, Bailly, Maryse, Larsen, Scott D., Neubig, Richard R., Khaw, Peng T.

Volltext

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors von Waldschmidt, Helen V, Homan, Kristoff T, Cruz-Rodríguez, Osvaldo, Cato, Marilyn C, Waninger-Saroni, Jessica, Larimore, Kelly M, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y, Kirchhoff, Paul D, Koch, Walter J, Tesmer, John J. G, Larsen, Scott D

Volltext

5‑Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gen... von Kahl, Dylan J, Hutchings, Kim M, Lisabeth, Erika Mathes, Haak, Andrew J, Leipprandt, Jeffrey R, Dexheimer, Thomas, Khanna, Dinesh, Tsou, Pei-Suen, Campbell, Phillip L, Fox, David A, Wen, Bo, Sun, Duxin, Bailie, Marc, Neubig, Richard R, Larsen, Scott D

Volltext

Diterpenoids from Gutierrezia sarothrae and G. microcephala: Chemical diversity, chemophenetics and implications to toxicity in grazing livestock von Gardner, Dale R., Cook, Daniel, Larsen, Scott W., Stonecipher, Clinton A., Johnson, Robert

Volltext

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein–Coupled Receptor Kinase 2 Inhibitors von Bouley, Renee, Waldschmidt, Helen V., Cato, M. Claire, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Yao, Xin-Qiu, Koch, Walter J., Larsen, Scott D., Tesmer, John J.G.

Volltext