The genomic landscape of response to EGFR blockade in colorectal cancer von Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.

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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors von Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael

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Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs von Reddy, Tejaswini P, Choi, Dong S, Anselme, Ann C, Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Chang, Jenny C, Rosato, Roberto R

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First-in-human trial exploring safety, antitumor activity, and pharmacokinetics of Sym013, a recombinant pan-HER antibody mixture, in advanced epithelial malignancies von Berlin, Jordan, Tolcher, Anthony W., Ding, Cliff, Whisenant, Jennifer G., Horak, Ivan D., Wood, Debra L., Nadler, Paul I., Hansen, Ulla Holm, Lantto, Johan, Skartved, Niels Jørgen Ø., Pedersen, Mikkel W., Patnaik, Amita

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Pan‐HER—An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand‐induced EGFR homo‐ and heterodimers von Ellebæk, Sofie, Brix, Susanne, Grandal, Michael, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Poulsen, Thomas Tuxen

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Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms von Grandal, Michael M, Havrylov, Serhiy, Poulsen, Thomas T, Koefoed, Klaus, Dahlman, Anna, Galler, Gunther R, Conrotto, Paolo, Collins, Sara, Eriksen, Karsten W, Kaufman, Dafna, Woude, George F Vande, Jacobsen, Helle J, Horak, Ivan D, Kragh, Michael, Lantto, Johan, Bouquin, Thomas, Park, Morag, Pedersen, Mikkel W

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A Focused Antibody Library for Improved Hapten Recognition von Persson, Helena, Lantto, Johan, Ohlin, Mats

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Capturing the Natural Diversity of the Human Antibody Response against Vaccinia Virus von LANTTO, Johan, HANSEN, Margit Haahr, HAURUM, John, JENSEN, Allan, RASMUSSEN, Søren Kofoed, STEINAA, Lucilla, POULSEN, Tine R, DUGGAN, Jackie, DENNIS, Mike, NAYLOR, Irene, EASTERBROOK, Linda, BREGENHOLT, Søren

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Passive Immunotherapies Protect WRvFire and IHD-J-Luc Vaccinia Virus-Infected Mice from Lethality by Reducing Viral Loads in the Upper Respiratory Tract and Internal Organs von ZAITSEVA, Marina, KAPNICK, Senta M, LANTTO, Johan, WEIR, Jerry P, GOLDING, Hana, MESEDA, Clement A, SHOTWELL, Elisabeth, KING, Lisa R, MANISCHEWITZ, Jody, SCOTT, John, KODIHALLI, Shantha, MERCHLINSKY, Michael, NIELSEN, Henriette

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Functional Consequences of Insertions and Deletions in the Complementarity-determining Regions of Human Antibodies von Lantto, Johan, Ohlin, Mats

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A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge von Parker, Scott, D'Angelo, June, Buller, R. Mark, Smee, Donald F., Lantto, Johan, Nielsen, Henriette, Jensen, Allan, Prichard, Mark, George, Sarah L.

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity von Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan

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Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts von Rosato, Roberto R., Choi, Don S., Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Chang, Jenny C.

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CD4 + and CD8a + PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models von Kristensen, Lotte K, Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C, Poulsen, Thomas T, Galler, Gunther R, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Nielsen, Carsten H, Kjaer, Andreas

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Abstract 1797: Preclinical characterization of Sym024, a novel anti-CD73 antibody von Jakobsen, Janus S., Riva, Matteo, Melander, Maria C., Hansen, Randi W., Kofoed, Klaus, Pedersen, Mikkel W., Deckert, Jutta, Hansen, Lene, Skartved, Niels Jorgen, Lantto, Johan, Frohlich, Camilla, Grandal, Michael Monrad

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Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance von Pedersen, Mikkel W, Jacobsen, Helle J, Koefoed, Klaus, Dahlman, Anna, Kjær, Ida, Poulsen, Thomas T, Meijer, Per-Johan, Nielsen, Lars S, Horak, Ivan D, Lantto, Johan, Kragh, Michael

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An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression von Schwarz, Luis J, Hutchinson, Katherine E, Rexer, Brent N, Estrada, Mónica Valeria, Gonzalez Ericsson, Paula I, Sanders, Melinda E, Dugger, Teresa C, Formisano, Luigi, Guerrero-Zotano, Angel, Red-Brewer, Monica, Young, Christian D, Lantto, Johan, Pedersen, Mikkel W, Kragh, Michael, Horak, Ivan D, Arteaga, Carlos L

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Abstract 3822: Characterization of the first chicken-derived anti-PD-1 clinical stage antibody with a unique epitope and promising anticancer activity von Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Melander, Maria C., Galler, Gunther, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D., Kragh, Michael, Pedersen, Mikkel W., Koefoed, Klaus

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Abstract 5626: Preclinical characterization of Sym022, a novel anti-LAG3 antibody von Grandal, Michael M., Melander, Maria C., Bhatia, Vikram K., Gjetting, Torben, Lindsted, Trine, Fröhlich, Camilla, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Kofoed, Klaus, Pedersen, Mikkel W.

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Abstract 1723: CD4+ and CD8a+ PET imaging in syngeneic mouse models for prediction of immuno-therapeutic response von Kristensen, Lotte K., Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C., Poulsen, Thomas T., Galler, Gunther R., Lantto, Johan, Horak, Ivan D., Kragh, Michael, Nielsen, Carsten H., Kjaer, Andreas

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