The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia von Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.

Volltext

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia von Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A

Volltext

The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells von Fiorcari, Stefania, Brown, Wells S, McIntyre, Bradley W, Estrov, Zeev, Maffei, Rossana, O'Brien, Susan, Sivina, Mariela, Hoellenriegel, Julia, Wierda, William G, Keating, Michael J, Ding, Wei, Kay, Neil E, Lannutti, Brian J, Marasca, Roberto, Burger, Jan A

Volltext

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models von Vaisitti, Tiziana, Arruga, Francesca, Vitale, Nicoletta, Lee, Thanh-Trang, Ko, Mira, Chadburn, Amy, Braggio, Esteban, Di Napoli, Arianna, Iannello, Andrea, Allan, John N., Miller, Langdon L., Lannutti, Brian J., Furman, Richard R., Jessen, Katti A., Deaglio, Silvia

Volltext

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia von Brown, Jennifer R., Byrd, John C., Coutre, Steven E., Benson, Don M., Flinn, Ian W., Wagner-Johnston, Nina D., Spurgeon, Stephen E., Kahl, Brad S., Bello, Celeste, Webb, Heather K., Johnson, Dave M., Peterman, Sissy, Li, Daniel, Jahn, Thomas M., Lannutti, Brian J., Ulrich, Roger G., Yu, Albert S., Miller, Langdon L., Furman, Richard R.

Volltext

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability von Lannutti, Brian J., Meadows, Sarah A., Herman, Sarah E.M., Kashishian, Adam, Steiner, Bart, Johnson, Amy J., Byrd, John C., Tyner, Jeffrey W., Loriaux, Marc M., Deininger, Mike, Druker, Brian J., Puri, Kamal D., Ulrich, Roger G., Giese, Neill A.

Volltext

PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma von Meadows, Sarah A., Vega, Francisco, Kashishian, Adam, Johnson, Dave, Diehl, Volker, Miller, Langdon L., Younes, Anas, Lannutti, Brian J.

Volltext

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival sig... von Herman, Sarah E.M., Gordon, Amber L., Wagner, Amy J., Heerema, Nyla A., Zhao, Weiqiang, Flynn, Joseph M., Jones, Jeffrey, Andritsos, Leslie, Puri, Kamal D., Lannutti, Brian J., Giese, Neill A., Zhang, Xiaoli, Wei, Lai, Byrd, John C., Johnson, Amy J.

Volltext

The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma von Jiang, Vivian Changying, Liu, Yang, Jordan, Alexa, McIntosh, Joseph, Li, Yijing, Che, Yuxuan, Jessen, Katti A., Lannutti, Brian J., Wang, Michael

Volltext

Targeting Nonclassical Oncogenes for Therapy in T-ALL von Subramaniam, Prem S., Whye, Dosh W., Efimenko, Evgeni, Chen, Jianchung, Tosello, Valeria, De Keersmaecker, Kim, Kashishian, Adam, Thompson, Mary Ann, Castillo, Mireia, Cordon-Cardo, Carlos, Davé, Utpal P., Ferrando, Adolfo, Lannutti, Brian J., Diacovo, Thomas G.

Volltext

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia von Byrd, John C, Harrington, Bonnie, O’Brien, Susan, Jones, Jeffrey A, Schuh, Anna, Devereux, Steve, Chaves, Jorge, Wierda, William G, Awan, Farrukh T, Brown, Jennifer R, Hillmen, Peter, Stephens, Deborah M, Ghia, Paolo, Barrientos, Jacqueline C, Pagel, John M, Woyach, Jennifer, Johnson, Dave, Huang, Jane, Wang, Xiaolin, Kaptein, Allard, Lannutti, Brian J, Covey, Todd, Fardis, Maria, McGreivy, Jesse, Hamdy, Ahmed, Rothbaum, Wayne, Izumi, Raquel, Diacovo, Thomas G, Johnson, Amy J, Furman, Richard R

Volltext

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia von Davids, Matthew S., Deng, Jing, Wiestner, Adrian, Lannutti, Brian J., Wang, Lili, Wu, Catherine J., Wilson, Wyndham H., Brown, Jennifer R., Letai, Anthony

Volltext

Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model von Niemann, Carsten U, Mora-Jensen, Helena I, Dadashian, Eman L, Krantz, Fanny, Covey, Todd, Chen, Shih-Shih, Chiorazzi, Nicholas, Izumi, Raquel, Ulrich, Roger, Lannutti, Brian J, Wiestner, Adrian, Herman, Sarah E M

Volltext

Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1 von Chiron, David, Martin, Peter, Di Liberto, Maurizio, Huang, Xiangao, Ely, Scott, Lannutti, Brian J., Leonard, John P., Mason, Christopher E., Chen-Kiang, Selina

Volltext

The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia von Herman, Sarah E.M., Lapalombella, Rosa, Gordon, Amber L., Ramanunni, Asha, Blum, Kristie A., Jones, Jeffrey, Zhang, Xiaoli, Lannutti, Brian J., Puri, Kamal D., Muthusamy, Natarajan, Byrd, John C., Johnson, Amy J.

Volltext

The phosphatidylinositol 3‐kinases (PI3K) inhibitor GS‐1101 synergistically potentiates histone deacetylase inhibitor‐induced proliferation inhibition and apoptosis through the ina... von Bodo, Juraj, Zhao, Xiaoxian, Sharma, Arishya, Hill, Brian T., Portell, Craig A., Lannutti, Brian J., Almasan, Alexandru, Hsi, Eric D.

Volltext

Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals von Lapalombella, Rosa, Yeh, Yuh-Ying, Wang, Liwen, Ramanunni, Asha, Rafiq, Sarwish, Jha, Shruti, Staubli, Justin, Lucas, David M., Mani, Rajeswaran, Herman, Sarah E.M., Johnson, Amy J., Lozanski, Arletta, Andritsos, Leslie, Jones, Jeffrey, Flynn, Joseph M., Lannutti, Brian, Thompson, Peter, Algate, Paul, Stromatt, Scott, Jarjoura, David, Mo, Xiaokui, Wang, Dasheng, Chen, Ching-Shih, Lozanski, Gerard, Heerema, Nyla A., Tridandapani, Susheela, Freitas, Michael A., Muthusamy, Natarajan, Byrd, John C.

Volltext

Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity von Mouchemore, Kellie A, Sampaio, Natalia G, Murrey, Michael W, Stanley, E. Richard, Lannutti, Brian J, Pixley, Fiona J

Volltext

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor von Burke, Russell T, Meadows, Sarah, Loriaux, Marc M, Currie, Kevin S, Mitchell, Scott A, Maciejewski, Patricia, Clarke, Astrid S, Dipaolo, Julie A, Druker, Brian J, Lannutti, Brian J, Spurgeon, Stephen E

Volltext

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML von Goodwin, Charles B, Li, Xing Jun, Mali, Raghuveer S., Chan, Gordon, Kang, Michelle, Liu, Ziyue, Vanhaesebroeck, Bart, Neel, Benjamin G., Loh, Mignon L., Lannutti, Brian J., Kapur, Reuben, Chan, Rebecca J.

Volltext