IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity von Landoni, Elisa, Woodcock, Mark G., Barragan, Gabriel, Casirati, Gabriele, Cinella, Vincenzo, Stucchi, Simone, Flick, Leah M., Withers, Tracy A., Hudson, Hanna, Casorati, Giulia, Dellabona, Paolo, Genovese, Pietro, Savoldo, Barbara, Metelitsa, Leonid S., Dotti, Gianpietro

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Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells von Huckaby, Justin T, Landoni, Elisa, Jacobs, Timothy M, Savoldo, Barbara, Dotti, Gianpietro, Lai, Samuel K

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Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling von Landoni, Elisa, Fuca, Giovanni, Wang, Jian, Chirasani, Venkat R., Yao, Zhiyuan, Dukhovlinova, Elena, Ferrone, Soldano, Savoldo, Barbara, Hong, Lee K., Shou, Peishun, Musio, Silvia, Padelli, Francesco, Finocchiaro, Gaetano, Droste, Miriam, Kuhlman, Brian, Shamshiev, Abdijapar, Pellegatta, Serena, Dokholyan, Nikolay, Dotti, Gianpietro

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CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma von Giraudo, Lidia, Cattaneo, Giulia, Gammaitoni, Loretta, Iaia, Ilenia, Donini, Chiara, Massa, Annamaria, Centomo, Maria Laura, Basiricò, Marco, Vigna, Elisa, Pisacane, Alberto, Picciotto, Franco, Berrino, Enrico, Marchiò, Caterina, Merlini, Alessandra, Paruzzo, Luca, Poletto, Stefano, Caravelli, Daniela, Biolato, Andrea Michela, Bortolot, Valentina, Landoni, Elisa, Ventin, Marco, Ferrone, Cristina R, Aglietta, Massimo, Dotti, Gianpietro, Leuci, Valeria, Carnevale-Schianca, Fabrizio, Sangiolo, Dario

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Eradication of Neuroblastoma by T Cells Redirected with an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15 von Chen, Yuhui, Sun, Chuang, Landoni, Elisa, Metelitsa, Leonid, Dotti, Gianpietro, Savoldo, Barbara

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Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors von Fuca, Giovanni, Reppel, Loic, Landoni, Elisa, Savoldo, Barbara, Dotti, Gianpietro

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GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision von Wang, Kai, Chen, Yuhui, Ahn, Sarah, Zheng, Min, Landoni, Elisa, Dotti, Gianpietro, Savoldo, Barbara, Han, Zongchao

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Dual-targeting CAR-T cells with optimal co-stimulation and metabolic fitness enhance antitumor activity and prevent escape in solid tumors von Hirabayashi, Koichi, Du, Hongwei, Xu, Yang, Shou, Peishun, Zhou, Xin, Fuca, Giovanni, Landoni, Elisa, Sun, Chuang, Chen, Yuhui, Savoldo, Barbara, Dotti, Gianpietro

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In vitro elimination of epidermal growth factor receptor‐overexpressing cancer cells by CD32A‐chimeric receptor T cells in combination with cetuximab or panitumumab von Caratelli, Sara, Arriga, Roberto, Sconocchia, Tommaso, Ottaviani, Alessio, Lanzilli, Giulia, Pastore, Donatella, Cenciarelli, Carlo, Venditti, Adriano, Del Principe, Maria Ilaria, Lauro, Davide, Landoni, Elisa, Du, Hongwei, Savoldo, Barbara, Ferrone, Soldano, Dotti, Gianpietro, Sconocchia, Giuseppe

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CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes von Leuci, Valeria, Donini, Chiara, Grignani, Giovanni, Rotolo, Ramona, Mesiano, Giulia, Fiorino, Erika, Gammaitoni, Loretta, D'Ambrosio, Lorenzo, Merlini, Alessandra, Landoni, Elisa, Medico, Enzo, Capellero, Sonia, Giraudo, Lidia, Cattaneo, Giulia, Iaia, Ilenia, Pignochino, Ymera, Basirico, Marco, Vigna, Elisa, Pisacane, Alberto, Fagioli, Franca, Ferrone, Soldano, Aglietta, Massimo, Dotti, Gianpietro, Sangiolo, Dario

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Abstract 1544: Generation of ALK CAR-T cells for neuroblastoma therapy von Bergaggio, Elisa, Tai, Wei-Tien, Aroldi, Andrea, Mota, Ineês, Alvarado, Diego, Landoni, Elisa, Metovic, Jasna, Nüesch, Manuel, Blasco-Patiño, Rafael, Papotti, Mauro, Dotti, Gianpietro, Chiarle, Roberto

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4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20 von Dou, Zhangqi, Bonacci, Thomas Raphael, Shou, Peishun, Landoni, Elisa, Woodcock, Mark G., Sun, Chuang, Savoldo, Barbara, Herring, Laura E., Emanuele, Michael J., Song, Feifei, Baldwin, Albert S., Wan, Yisong, Dotti, Gianpietro, Zhou, Xin

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A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor von Landoni, Elisa, Smith, Christof C., Fuca, Giovanni, Chen, Yuhui, Sun, Chuang, Vincent, Benjamin G., Metelitsa, Leonid S., Dotti, Gianpietro, Savoldo, Barbara

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Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors von Hirabayashi, Koichi, Du, Hongwei, Xu, Yang, Shou, Peishun, Zhou, Xin, Fucá, Giovanni, Landoni, Elisa, Sun, Chuang, Chen, Yuhui, Savoldo, Barbara, Dotti, Gianpietro

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NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD von Mastaglio, Sara, Genovese, Pietro, Magnani, Zulma, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D, Naldini, Luigi, Bonini, Chiara

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209. TCR Gene Editing in a Single Step of T Cell Activation To Redirect T Cell Specificity and Prevent GvHD von Genovese, Pietro, Mastaglio, Sara, Magnani, Zulma, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara

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752. Single Chain TCR Gene Editing in Adoptive Cell Therapy for Multiple Myeloma von Mastaglio, Sara, Genovese, Pietro, Magnani, Zulma, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Rocchi, Martina, Oliveira, Giacomoq, Escobar, Giulia, Casucci, Monica, Gentner, Bernhard, Spinelli, Antonello, Mondino, Anna, Bondanza, Attilio, Vago, Luca, Ponzoni, Maurilio, Ciceri, Fabio, Holmes, Micheal, Naldini, Luigi, Bonini, Chiara

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NATURAL KILLER T-CELLS AND METHODS OF USING THE SAME von SAVOLDO, Barbara, LANDONI, Elisa, DOTTI, Gianpietro

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NATURAL KILLER T-CELLS AND METHODS OF USING THE SAME von SAVOLDO, Barbara, LANDONI, Elisa, DOTTI, Gianpietro

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Methods and compositions for the reduction of chimeric antigen receptor tonic signaling von SHAMSHIEV, Abdijapar, DROSTE, Miriam, LANDONI, Elisa, DOTTI, Gianpietro

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