Cohesin residency determines chromatin loop patterns von Costantino, Lorenzo, Hsieh, Tsung-Han S, Lamothe, Rebecca, Darzacq, Xavier, Koshland, Douglas

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Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes von Aliaga Goltsman, Daniela S., Alexander, Lisa M., Lin, Jyun-Liang, Fregoso Ocampo, Rodrigo, Freeman, Benjamin, Lamothe, Rebecca C., Perez Rivas, Andres, Temoche-Diaz, Morayma M., Chadha, Shailaja, Nordenfelt, Natalie, Janson, Owen P., Barr, Ian, Devoto, Audra E., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T.

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Cancer Vulnerabilities Unveiled by Genomic Loss von Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.

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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability von Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen

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The spatial regulation of condensin activity in chromosome condensation von Lamothe, Rebecca, Costantino, Lorenzo, Koshland, Douglas E

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355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses von Drain, Allison P, Rouillard, Nicholas, Swanson, Nathaniel, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

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1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells von Narayan, Santosh, Drain, Allison P, Swanson, Nathaniel, Rouillard, Nicholas, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

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Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses von Elde, Nels C., Child, Stephanie J., Eickbush, Michael T., Kitzman, Jacob O., Rogers, Kelsey S., Shendure, Jay, Geballe, Adam P., Malik, Harmit S.

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Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering for Cell Therapy Development von Cost, Gregory J., Lamothe, Rebecca C., Storlie, Meghan D., Rivas, Andres, Espinosa, Diego A., Goltsman, Daniela S.A., Alexander, Lisa, Butterfield, Cristina N., Brown, Christopher T., Thomas, Brian C.

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Abstract B077: Comprehensive molecular characterization and high-throughput chemical screening identifies genetic dependencies and molecular vulnerabilities in glioblastoma cell li... von Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Ramkissoon, Lori A., Pellton, Kristine, Schumacher, Steven E., Lamothe, Rebecca, Cheah, Jaime H., Haidar, Sam, Kang, Yun J., Knoff, David S., Maire, Cecile L., Olausson, Karl H., Song, Wenyu, Idbaih, Ahmed, Rinne, Mikael L., Reardon, David A., Wen, Patrick Y., Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan J., Beroukhim, Rameen, Ligon, Keith L.

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Abstract 4974: Pharmacogenomic interactions in glioblastoma cell line models von Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Olausson, Karl H., Ramkissoon, Lori A., Schumacher, Steven, Lamothe, Rebecca, Cheah, Jaime H., Pellton, Kristine, Haidar, Sam, Kang, Yun J., Paolella, Brenton R., Maire, Cecile, Song, Wenyu, Meng, Alice, Idbaih, Ahmed, Rinne, Mikael L., Reardon, David A., Wen, Patrick Y., Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Beroukhim, Rameen, Ligon, Keith L.

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Abstract B66: Identification of genetic and non-genetic dependencies in glioblastoma cell lines targeted by small molecules von Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Ramkissoon, Lori A., Lamothe, Rebecca, Cheah, Jaime H., Schumacher, Steven E., Haidar, Sam, Clemons, Paul A., Shamji, Alykhan, Ligon, Keith L., Beroukhim, Rameen

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BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS von Paolella, Brenton, Gibson, William, Urbanski, Laura, Alberta, John, Zack, Travis, Bandopadhayay, Pratiti, Nichols, Caitlin, Brown, Meredith, Lamothe, Rebecca, Yu, Yong, Choi, Peter, Obeng, Esther, Wei, Guo, Wong, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara, Root, David, Cowley, Glenn, Stiles, Charles, Ebert, Benjamin, Hahn, William, Reed, Robin, Beroukhim, Rameen

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Abstract A103: High-throughput genomic and chemical screening in glioblastoma cell lines von Ferrer-Luna, Ruben, Ramkissoon, Shakti, Cheah, Jaime, Lamothe, Rebecca, Schumacher, Steven, Shamji, Alykhan, Clemons, Paul, Reardon, David, Wen, Patrick, Schreiber, Stuart, Ligon, Keith, Beroukhim, Rameen

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Abstract 4369: Genome-wide copy number dependency analysis identifies partial copy loss of SF3B1 as a novel cancer vulnerability von Paolella, Brenton R., Gibson, William J., Urbanski, Laura M., Alberta, John A., Zack, Travis I., Bandopadhayay, Pratiti, Nichols, Caitlin A., Agarwalla, Pankaj K., Brown, Meredith S., Lamothe, Rebecca, Yu, Yong, Choi, Peter S., Obeng, Esther A., Heckl, Dirk, Ebert, Benjamin L., Wei, Guo, Wang, Belinda, Hahn, William C., Vazquez, Francisca, Weir, Barbara A., Stiles, Charles D., Reed, Robin, Beroukhim, Rameen

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ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

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ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

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ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

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NOVEL ENGINEERED AND CHIMERIC NUCLEASES von LIN, Jyun-Liang, TEMOCHE-DIAZ, Morayma M, BUTTERFIELD, Cristina, BROOKS, Alan, LAMOTHE, Rebecca, THOMAS, Brian C, BROWN, Christopher, COST, Greg

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ENDONUCLEASE SYSTEMS von DEVOTO, AUDRA, GOLTSMAN, DANIELA S.A, THOMAS, BRIAN C, BUTTERFIELD, CRISTINA, ALEXANDER, LISA, BROWN, CHRISTOPHER, LAMOTHE, REBECCA

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