New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation von Lam, Patrick Y.S, Clark, Charles G, Saubern, Simon, Adams, Jessica, Winters, Michael P, Chan, Dominic M.T, Combs, Andrew

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Copper-promoted/catalyzed CN and CO bond cross-coupling with vinylboronic acid and its utilities von Lam, Patrick Y.S, Vincent, Guillaume, Bonne, Damien, Clark, Charles G

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Copper-catalyzed general CN and CO bond cross-coupling with arylboronic acid von Lam, Patrick Y.S, Vincent, Guillaume, Clark, Charles G, Deudon, Sophie, Jadhav, Prabhakar K

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New azole antagonists with high affinity for the P2Y1 receptor von Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

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2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents von Pi, Zulan, Sutton, James, Lloyd, John, Hua, Ji, Price, Laura, Wu, Qimin, Chang, Ming, Zheng, Joanna, Rehfuss, Robert, Huang, Christine S., Wexler, Ruth R., Lam, Patrick Y.S.

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Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds von Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Lapointe, Philippe, Martel, Alain, Qiao, Jennifer X., Hua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

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N-Arylation of α-aminoesters with p-tolylboronic acid promoted by copper(II) acetate von Lam, Patrick Y.S, Bonne, Damien, Vincent, Guillaume, Clark, Charles G, Combs, Andrew P

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Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 mo... von Qiao, Jennifer X., Cheney, Daniel L., Alexander, Richard S., Smallwood, Angela M., King, Sarah R., He, Kan, Rendina, Alan R., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.

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Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility von Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

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N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations von He, Kan, Qian, Mingxin, Wong, Harvey, Bai, Stephen A., He, Bing, Brogdon, Bernice, Grace, James E., Xin, Baomin, Wu, Jingtao, Ren, Shelly X., Zeng, Hang, Deng, Yuzhong, Graden, Danielle M., Olah, Timothy V., Unger, Steve E., Luettgen, Joseph M., Knabb, Robert M., Pinto, Donald J., Lam, Patrick Y.S., Duan, James, Wexler, Ruth R., Decicco, Carl P., Christ, David D., Grossman, Scott J.

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors von Patrick Y. S. Lam, Jahdav, Prabhakar K., Eyermann, Charles J., Hodge, C. Nicholas, Ru, Yu, Bacheler, Lee T., Meek, James L., Otto, Michael J., Rayner, Marlene M., Wong, Y. Nancy, Chang, Chong-Hwan, Weber, Patricia C., Jackson, David A., Sharpe, Thomas R., Erickson-Viitanen, Susan

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Advances in Carbon–Element Bond Construction under Chan–Lam Cross-Coupling Conditions: A Second Decade von Vijayan, Ajesh, Rao, Desaboini Nageswara, Radhakrishnan, K. V., Lam, Patrick Y. S., Das, Parthasarathi

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First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls von Ishida, Moeka, Adachi, Rina, Kobayashi, Kazuki, Yamamoto, Yukiko, Kawahara, Chinatsu, Yamada, Tsuyoshi, Aoyama, Hiroshi, Kanomata, Kyohei, Akai, Shuji, Lam, Patrick Y. S, Sajiki, Hironao, Ikawa, Takashi

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Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors von Varnes, Jeffrey G., Wacker, Dean A., Jacobson, Irina C., Quan, Mimi L., Ellis, Christopher D., Rossi, Karen A., He, Ming Y., Luettgen, Joseph M., Knabb, Robert M., Bai, Steven, He, Kan, Lam, Patrick Y.S., Wexler, Ruth R.

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α-Nitrogen activating effect in the room temperature copper-promoted N-arylation of heteroarylcarboxamides with phenyl siloxane or p-toluylboronic acid von Lam, Patrick Y.S, Deudon, Sophie, Hauptman, Elisabeth, Clark, Charles G

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Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure von Jackson, Michael R, Cox, Kristie D, Baugh, Simon D P, Wakeen, Luke, Rashad, Adel A, Lam, Patrick Y S, Polyak, Boris, Jorns, Marilyn Schuman

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Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase von Baugh, Simon D.P., Jackson, Michael R., Rashad, Adel Ahmed, Reitz, Allen B., Lam, Patrick Y.S., Jorns, Marilyn Schuman

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Copper(ii)-catalyzed Chan-Lam cross-coupling: chemoselective N-arylation of aminophenols von Siva Reddy, A, Ranjith Reddy, K, Nageswar Rao, D, Jaladanki, Chaitanya K, Bharatam, Prasad V, Lam, Patrick Y S, Das, Parthasarathi

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selec... von Pinto, Donald J. P, Orwat, Michael J, Koch, Stephanie, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela, Wong, Pancras C, Rendina, Alan R, Luettgen, Joseph M, Knabb, Robert M, He, Kan, Xin, Baomin, Wexler, Ruth R, Lam, Patrick Y. S

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Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation von Hwang, Nicky, Sun, Liren, Noe, Daisy, Lam, Patrick Y. S, Zhou, Tianlun, Block, Timothy M, Du, Yanming

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