The Development Process for Discovery and Clinical Advancement of Modern Antimalarials von Ashton, Trent D, Devine, Shane M, Möhrle, Jörg J, Laleu, Benoît, Burrows, Jeremy N, Charman, Susan A, Creek, Darren J, Sleebs, Brad E

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Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates von Low, Jian Liang, Wu, Mu-Lu, Aziz, Dinah Binte, Laleu, Benoît, Dick, Thomas

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In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum von Müller, Joachim, Aguado, Adriana, Laleu, Benoît, Balmer, Vreni, Ritler, Dominic, Hemphill, Andrew

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Actives from MMV Open Access Boxes? A suggested way forward von Samby, Kirandeep, Willis, Paul A, Burrows, Jeremy N, Laleu, Benoît, Webborn, Peter J H

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 von Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa

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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent von Aoyama, Tomonori, Paik, Yong-Han, Watanabe, Sumio, Laleu, Benoît, Gaggini, Francesca, Fioraso-Cartier, Laetitia, Molango, Sophie, Heitz, Freddy, Merlot, Cédric, Szyndralewiez, Cédric, Page, Patrick, Brenner, David A.

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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series von Palmer, Michael J, Deng, Xiaoyi, Watts, Shawn, Krilov, Goran, Gerasyuto, Aleksey, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, White, Karen L, Striepen, Josefine, Bath, Jade, Schindler, Kyra A, Yeo, Tomas, Shackleford, David M, Mok, Sachel, Deni, Ioanna, Lawong, Aloysus, Huang, Ann, Chen, Gong, Wang, Wen, Jayaseelan, Jaya, Katneni, Kasiram, Patil, Rahul, Saunders, Jessica, Shahi, Shatrughan P, Chittimalla, Rajesh, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Wittlin, Sergio, Tumwebaze, Patrick K, Rosenthal, Philip J, Cooper, Roland A, Aguiar, Anna Caroline Campos, Guido, Rafael V. C, Pereira, Dhelio B, Mittal, Nimisha, Winzeler, Elizabeth A, Tomchick, Diana R, Laleu, Benoît, Burrows, Jeremy N, Rathod, Pradipsinh K, Fidock, David A, Charman, Susan A, Phillips, Margaret A

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Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni von Pasche, Valérian, Laleu, Benoît, Keiser, Jennifer

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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors von Gerets, Helga H J, Delaunois, Annie, Cardenas, Alvaro, Class, Reiner, Fleurance, Renaud, de Haro, Teresa, Laleu, Benoît, Lowe, Martin A, Rosseels, Marie-Luce, Valentin, Jean-Pierre

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Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention von Nie, Zhe, Bonnert, Roger, Tsien, Jet, Deng, Xiaoyi, Higgs, Christopher, El Mazouni, Farah, Zhang, Xiaoyu, Li, Renzhe, Ho, Nhi, Feher, Victoria, Paulsen, Janet, Shackleford, David M., Katneni, Kasiram, Chen, Gong, Ng, Alice C. F., McInerney, Mitchell, Wang, Wen, Saunders, Jessica, Collins, Daniel, Yan, Dandan, Li, Peng, Campbell, Michael, Patil, Rahul, Ghoshal, Atanu, Mondal, Pallab, Kundu, Abhijit, Chittimalla, Rajesh, Mahadeva, Muralikumar, Kokkonda, Sreekanth, White, John, Das, Rishi, Mukherjee, Partha, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Malmstrom, Robert, Lawrenz, Morgan, Rodriguez-Granillo, Agustina, Rathod, Pradipsinh K., Tomchick, Diana R., Palmer, Michael J., Laleu, Benoît, Qin, Tian, Charman, Susan A., Phillips, Margaret A.

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Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box von Pasche, Valérian, Laleu, Benoît, Keiser, Jennifer

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Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus von Negatu, Dereje Abate, Beuchel, Andreas, Madani, Abdeldjalil, Alvarez, Nadine, Chen, Chao, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D, Laleu, Benoît, Gengenbacher, Martin, Dartois, Véronique, Imming, Peter, Dick, Thomas

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ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development von Mishra, Siddhartha, Malhotra, Nipun, Laleu, Benoît, Chakraborti, Soumyananda, Yogavel, Manickam, Sharma, Amit

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Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis von Ma, Jingyi, Eadie, Kimberly, Schippers, Marij, Fahal, Ahmed, Laleu, Benoît, Verbon, Annelies, van de Sande, Wendy W J

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Exploiting the Divergent Reactivity of Aryl-Palladium Intermediates for the Rapid Assembly of Fluorene and Phenanthrene Derivatives von Zhao, Ya-Bin, Mariampillai, Brian, Candito, David A, Laleu, Benoît, Li, Mengzhou, Lautens, Mark

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Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum von Pires, Camilla Valente, Cassandra, Debora, Xu, Shulin, Laleu, Benoit, Burrows, Jeremy N, Adams, John H

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MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity von Bosc, Nicolas, Felix, Eloy, Gardner, J. Mark F., Mills, James, Timmerman, Martijn, Asveld, Dennis, Rensen, Kim, Mukherjee, Partha, Das, Rishi, Chenu, Elodie, Besson, Dominique, Burrows, Jeremy N., Duffy, James, Laleu, Benoît, Guantai, Eric M., Leach, Andrew R.

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Global Health Priority BoxProactive Pandemic Preparedness von Adam, Anna, Besson, Dominique, Bryant, Rob, Rees, Sarah, Willis, Paul A., Burrows, Jeremy N., Hooft van Huisjduijnen, Rob, Laleu, Benoît, Norton, Larry, Canan, Stacie, Hawryluk, Natalie, Robinson, Dale, Palmer, Mike, Samby, Kirandeep Kaur

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Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm von Preston, Sarah, Jiao, Yaqing, Jabbar, Abdul, McGee, Sean L., Laleu, Benoît, Willis, Paul, Wells, Timothy N.C., Gasser, Robin B.

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Chiral Selectivity in the Binding of [4]Helicene Derivatives to Double-Stranded DNA von Kel, Oksana, Fürstenberg, Alexandre, Mehanna, Nathalie, Nicolas, Cyril, Laleu, Benoît, Hammarson, Martin, Albinsson, Bo, Lacour, Jerôme, Vauthey, Eric

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