Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation von Przybyla, Laralynne, Lakins, Johnathon N., Weaver, Valerie M.

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Controlled modelling of human epiblast and amnion development using stem cells von Zheng, Yi, Xue, Xufeng, Shao, Yue, Wang, Sicong, Esfahani, Sajedeh Nasr, Li, Zida, Muncie, Jonathon M., Lakins, Johnathon N., Weaver, Valerie M., Gumucio, Deborah L., Fu, Jianping

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Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells von Muncie, Jonathon M., Ayad, Nadia M.E., Lakins, Johnathon N., Xue, Xufeng, Fu, Jianping, Weaver, Valerie M.

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Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression von Maller, Ori, Drain, Allison P., Barrett, Alexander S., Borgquist, Signe, Ruffell, Brian, Zakharevich, Igor, Pham, Thanh T., Gruosso, Tina, Kuasne, Hellen, Lakins, Johnathon N., Acerbi, Irene, Barnes, J. Matthew, Nemkov, Travis, Chauhan, Aastha, Gruenberg, Jessica, Nasir, Aqsa, Bjarnadottir, Olof, Werb, Zena, Kabos, Peter, Chen, Yunn-Yi, Hwang, E. Shelley, Park, Morag, Coussens, Lisa M., Nelson, Andrew C., Hansen, Kirk C., Weaver, Valerie M.

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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling von Levental, Kandice R., Yu, Hongmei, Kass, Laura, Lakins, Johnathon N., Egeblad, Mikala, Erler, Janine T., Fong, Sheri F.T., Csiszar, Katalin, Giaccia, Amato, Weninger, Wolfgang, Yamauchi, Mitsuo, Gasser, David L., Weaver, Valerie M.

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Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression von Laklai, Hanane, Miroshnikova, Yekaterina A, Pickup, Michael W, Collisson, Eric A, Kim, Grace E, Barrett, Alex S, Hill, Ryan C, Lakins, Johnathon N, Schlaepfer, David D, Mouw, Janna K, LeBleu, Valerie S, Roy, Nilotpal, Novitskiy, Sergey V, Johansen, Julia S, Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A, Wood, Laura D, Hebrok, Matthias, Hansen, Kirk, Moses, Harold L, Weaver, Valerie M

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Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression von Mouw, Janna K, Yui, Yoshihiro, Damiano, Laura, Bainer, Russell O, Lakins, Johnathon N, Acerbi, Irene, Ou, Guanqing, Wijekoon, Amanda C, Levental, Kandice R, Gilbert, Penney M, Hwang, E Shelley, Chen, Yunn-Yi, Weaver, Valerie M

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A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer von Stashko, Connor, Hayward, Mary-Kate, Northey, Jason J., Pearson, Neil, Ironside, Alastair J., Lakins, Johnathon N., Oria, Roger, Goyette, Marie-Anne, Mayo, Lakyn, Russnes, Hege G., Hwang, E. Shelley, Kutys, Matthew L., Polyak, Kornelia, Weaver, Valerie M.

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Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini von Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

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Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer von Drain, Allison P, Zahir, Nastaran, Northey, Jason J, Zhang, Hui, Huang, Po-Jui, Maller, Ori, Lakins, Johnathon N, Yu, Xinmiao, Leight, Jennifer L, Alston-Mills, Brenda P, Hwang, E Shelley, Chen, Yunn-Yi, Park, Catherine C, Weaver, Valerie M

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Tensional homeostasis and the malignant phenotype von Paszek, Matthew J., Zahir, Nastaran, Johnson, Kandice R., Lakins, Johnathon N., Rozenberg, Gabriela I., Gefen, Amit, Reinhart-King, Cynthia A., Margulies, Susan S., Dembo, Micah, Boettiger, David, Hammer, Daniel A., Weaver, Valerie M.

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β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium von Weaver, Valerie M, Lelièvre, Sophie, Lakins, Johnathon N, Chrenek, Micah A, Jones, Jonathan C.R, Giancotti, Filippo, Werb, Zena, Bissell, Mina J

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Exploring the Link Between Human Embryonic Stem Cell Organization and Fate Using Tension-Calibrated Extracellular Matrix Functionalized Polyacrylamide Gels von Lakins, Johnathon N., Chin, Andrew R., Weaver, Valerie M.

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Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression von Laklai, Hanane, Miroshnikova, Yekaterina A., Pickup, Michael W., Collisson, Eric A., Kim, Grace E., Barrett, Alex S., Hill, Ryan C., Lakins, Johnathon N., Schlaepfer, David D., Mouw, Janna K., LeBleu, Valerie S., Roy, Nilotpal, Novitskiy, Sergey V., Johansen, Julia S., Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A., Wood, Laura D., Hebrok, Matthias, Hansen, Kirk, Moses, Harold L., Weaver, Valerie M.

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Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics von Muncie, Jonathon M, Falcón-Banchs, Roberto, Lakins, Johnathon N, Sohn, Lydia L, Weaver, Valerie M

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alpha 6 beta 4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- Kappa B-dependent resistance to apoptosis in 3D mammary acini von Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

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α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini von Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

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HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype von Gilbert, Penney M, Mouw, Janna K, Unger, Meredith A, Lakins, Johnathon N, Gbegnon, Mawuse K, Clemmer, Virginia B, Benezra, Miriam, Licht, Jonathan D, Boudreau, Nancy J, Tsai, Kelvin K C, Welm, Alana L, Feldman, Michael D, Weber, Barbara L, Weaver, Valerie M

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A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype von Cassereau, Luke, Miroshnikova, Yekaterina A., Ou, Guanqing, Lakins, Johnathon, Weaver, Valerie M.

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Evidence That Clusterin Has Discrete Chaperone and Ligand Binding Sites von Lakins, Johnathon N, Poon, Stephen, Easterbrook-Smith, Simon B, Carver, John A, Tenniswood, Martin P. R, Wilson, Mark R

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