Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition von Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) von Taylor, Alexander M, Côté, Alexandre, Hewitt, Michael C, Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G, Romero, F. Anthony, Crawford, Terry D, Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H, de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R, Cummings, Richard T, Dakin, Leslie A, Flynn, E. Megan, Huang, Oscar W, Kaufman, Susan, Keller, Patricia J, Kiefer, James R, Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J, Cochran, Andrea G, Bellon, Steve, Audia, James E, Magnuson, Steven, Albrecht, Brian K

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Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies von Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley

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Numerical modeling of linear doping profiles for high-voltage thin-film SOI devices von Shengdong Zhang, Sin, J.K.O., Lai, T.M.L., Ko, P.K.

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer von Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα) von Dragovich, Peter S., Adhikari, Pragya, Blake, Robert A., Blaquiere, Nicole, Chen, Jinhua, Cheng, Yun-Xing, den Besten, Willem, Han, Jinping, Hartman, Steven J., He, Jintang, He, Mingtao, Rei Ingalla, Ellen, Kamath, Amrita V., Kleinheinz, Tracy, Lai, Tommy, Leipold, Douglas D., Li, Chun Sing, Liu, Qi, Lu, Jiawei, Lu, Ying, Meng, Fanwei, Meng, Lingyao, Ng, Carl, Peng, Kaishan, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sadowsky, Jack D., Sampath, Deepak, Staben, Leanna, Staben, Steven T., Wai, John, Wan, Kunpeng, Wang, Xinxin, Wei, BinQing, Wertz, Ingrid E., Xin, Jianfeng, Xu, Keyang, Yao, Hui, Zang, Richard, Zhang, Donglu, Zhou, Hao, Zhao, Yongxin

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From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors von Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, An, Le, Ran, Yingqing, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley

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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis von Zhou, Yuebiao, Aliagas, Ignacio, Wang, Shumei, Li, Chun Sing, Liu, Zhiguo, Bowman, Christine M., Burdick, Daniel J., Clark, Kevin R., Dening, Tahnee J., Flygare, John, Ganti, Anjani, Girgis, Hany S., Hanan, Emily J., Harris, Seth F., Hu, Chloe, Kapadia, Sharookh B., Koehler, Michael F.T., Lai, Tommy, Liang, Jun, Liu, Xingrong, Ma, Fang, Mao, Jialin, Nicolai, Jeremy, Sims, Jessica, Unhayaker, Savita, Wai, John, Wang, Xiaojing, Wu, Ping, Xu, Yiming, Yen, Chun-Wan, Zhang, Renwei, Elfert, Torben F., Tan, Man-Wah, Kofoed, Eric M., Crawford, Terry D.

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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927 von Labadie, Sharada S., Li, Jun, Blake, Robert A., Chang, Jae H., Goodacre, Simon, Hartman, Steven J., Liang, Weiling, Kiefer, James R., Kleinheinz, Tracy, Lai, Tommy, Liao, Jiangpeng, Ortwine, Daniel F., Mody, Vidhi, Ray, Nicholas C., Roussel, Fabien, Vinogradova, Maia, Yeap, Siew Kuen, Zhang, Birong, Zheng, Xiaoping, Zbieg, Jason R., Liang, Jun, Wang, Xiaojing

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Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer von Zbieg, Jason R., Liang, Jun, Li, Jun, Blake, Robert A., Chang, Jae, Friedman, Lori, Goodacre, Simon, Hartman, Steven J., Rei Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Lai, Tommy, Liao, Jiangpeng, McLean, Nev, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing

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Object tracking with an AIS-inspired algorithm von Lai, T.W.C., Lau, H.Y.K.

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Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha von Zhang, Birong, Kiefer, James R., Blake, Robert A., Chang, Jae H., Hartman, Steven, Ingalla, Ellen Rei, Kleinheinz, Tracy, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Zhong, Yu, Nwachukwu, Jerome C., Nettles, Kendall W., Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Chen, Hai, Wang, Xiaojing, Liang, Jun

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From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors von Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, An, Le, Ran, Yingqing, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley

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Abstract A20: A leukemic model of acquired resistance to BET inhibition reveals a role for CBP/EP300 bromodomains in the regulation of c-MYC expression von Conery, Andrew R., Centore, Richard C., Hatton, Charlie, Neiss, Adrianne, Huang, Hon-Ren, Keller, Patricia J., Taylor, Alexander M., Cote, Alexandre, Hewitt, Michael C., Nasveschuk, Christopher G., Leblanc, Yves, Yao, Shihua, Pardo, Eneida, Zawadzke, Laura, Poy, Florence, Jayaram, Hari, Joshi, Shivangi, Sandy, Peter, Romero, Anthony, Crawford, Terry, Pastor, Richard, Lai, Tommy, Chen, Kevin, Wang, Jian, Magnuson, Steven, Albrecht, Brian K., Bellon, Steve, Bryant, Barbara M., Sims, Robert J.

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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy von Law, Man Fai, Ho, Rita, Cheung, Carmen K M, Tam, Lydia H P, Ma, Karen, So, Kent C Y, Ip, Bonaventure, So, Jacqueline, Lai, Jennifer, Ng, Joyce, Tam, Tommy H C

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Infrared Authentication of Ginseng Species: The Use of the 2-6PC Rule von Yap, Kevin Yi-Lwern, Henglai, Tommy Kok, Chan, Sui Yung, Lim, Chu Sing

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Infrared Authentication of Ginseng Species : The Use of the 2-6PC Rule : Application of analytical chemistry to botanicals and dietary supplements von YAP, Kevin Yi-Lwern, LAI, Tommy Kok Heng, SUI YUNG CHAN, CHU SING LIM

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TETRAHYDRO-PYRIDO[3,4-B]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF von LAI, Tommy, ZHANG, Birong, GOODACRE, Simon Charles, LIU, Zhiguo, ORTWINE, Daniel Fred, ZBIEG, Jason, WAI, John, LIAO, Jiangpeng, LABADIE, Sharada, WANG, Xiaojing, RAY, Nicholas Charles, LIANG, Jun, WANG, Tao

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TETRAHYDRO- PYRIDO[3,4- b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF von Ray, Nicholas Charles, Zbieg, Jason, Wang, Tao, Labadie, Sharada, Wai, John, Liao, Jiangpeng, Liang, Jun, Liu, Zhiguo, Wang, Xiaojing, Zhang, Birong, Goodacre, Simon Charles, Ortwine, Daniel Fred, Li, Jun, Lai, Tommy

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Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating IRE1-related diseases and disorders von Ashkenazi, Avi, Wang, Fei, Gibbons, Paul, Beveridge, Ramsay, Braun, Marie-Gabrielle, Fu, Leo, Zhao, Liang, Rudolph, Joachim, Schwarz, Jacob, Lee, Wendy, Ly, Cuong, Lai, Tommy

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