Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays von Kurata, Morito, Wolf, Natalie K, Lahr, Walker S, Weg, Madison T, Kluesner, Mitchell G, Lee, Samantha, Hui, Kai, Shiraiwa, Masano, Webber, Beau R, Moriarity, Branden S

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Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy von Pomeroy, Emily J., Hunzeker, John T., Kluesner, Mitchell G., Lahr, Walker S., Smeester, Branden A., Crosby, Margaret R., Lonetree, Cara-lin, Yamamoto, Kenta, Bendzick, Laura, Miller, Jeffrey S., Geller, Melissa A., Walcheck, Bruce, Felices, Martin, Webber, Beau R., Starr, Timothy K., Moriarity, Branden S.

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Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease von Johnson, Matthew J., Laoharawee, Kanut, Lahr, Walker S., Webber, Beau R., Moriarity, Branden S.

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Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments von Tabdanov, Erdem D., Rodríguez-Merced, Nelson J., Cartagena-Rivera, Alexander X., Puram, Vikram V., Callaway, Mackenzie K., Ensminger, Ethan A., Pomeroy, Emily J., Yamamoto, Kenta, Lahr, Walker S., Webber, Beau R., Moriarity, Branden S., Zhovmer, Alexander S., Provenzano, Paolo P.

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A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers von Wong, Derek P., Roy, Nand K., Zhang, Keman, Anukanth, Anusha, Asthana, Abhishek, Shirkey-Son, Nicole J., Dunmire, Samantha, Jones, Bryan J., Lahr, Walker S., Webber, Beau R., Moriarity, Branden S., Caimi, Paolo, Parameswaran, Reshmi

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CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells von Kluesner, Mitchell G., Lahr, Walker S., Lonetree, Cara-lin, Smeester, Branden A., Qiu, Xiaohong, Slipek, Nicholas J., Claudio Vázquez, Patricia N., Pitzen, Samuel P., Pomeroy, Emily J., Vignes, Madison J., Lee, Samantha C., Bingea, Samuel P., Andrew, Aneesha A., Webber, Beau R., Moriarity, Branden S.

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Germline T cell receptor exchange results in physiological T cell development and function von Rollins, Meagan R., Raynor, Jackson F., Miller, Ebony A., Butler, Jonah Z., Spartz, Ellen J., Lahr, Walker S., You, Yun, Burrack, Adam L., Moriarity, Branden S., Webber, Beau R., Stromnes, Ingunn M.

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CRISPR-Cas9 base editors and their current role in human therapeutics von Lahr, Walker S., Sipe, Christopher J., Skeate, Joseph G., Webber, Beau R., Moriarity, Branden S.

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A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes von Laoharawee, Kanut, Johnson, Matthew J., Lahr, Walker S., Sipe, Christopher J., Kleinboehl, Evan, Peterson, Joseph J., Lonetree, Cara-lin, Bell, Jason B., Slipek, Nicholas J., Crane, Andrew T., Webber, Beau R., Moriarity, Branden S.

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Correction of Fanconi Anemia Mutations Using Digital Genome Engineering von Sipe, Christopher J, Kluesner, Mitchell G, Bingea, Samuel P, Lahr, Walker S, Andrew, Aneesha A, Wang, Minjing, DeFeo, Anthony P, Hinkel, Timothy L, Laoharawee, Kanut, Wagner, John E, MacMillan, Margaret L, Vercellotti, Gregory M, Tolar, Jakub, Osborn, Mark J, McIvor, R Scott, Webber, Beau R, Moriarity, Branden S

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Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies von Skeate, Joseph G., Pomeroy, Emily J., Slipek, Nicholas J., Jones, Bryan J., Wick, Bryce J., Chang, Jae-Woong, Lahr, Walker S., Stelljes, Erin M., Patrinostro, Xiaobai, Barnes, Blake, Zarecki, Trevor, Krueger, Joshua B., Bridge, Jacob E., Robbins, Gabrielle M., McCormick, Madeline D., Leerar, John R., Wenzel, Kari T., Hornberger, Kathlyn M., Walker, Kirsti, Smedley, Dalton, Largaespada, David A., Otto, Neil, Webber, Beau R., Moriarity, Branden S.

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Development and testing of a versatile genome editing application reporter (V-GEAR) system von Kleinboehl, Evan W., Laoharawee, Kanut, Lahr, Walker S., Jensen, Jacob D., Peterson, Joseph J., Bell, Jason B., Webber, Beau R., Moriarity, Branden S.

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Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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Genome Engineering of Primary Human B Cells Using CRISPR/Cas9 von Laoharawee, Kanut, Johnson, Matthew J, Lahr, Walker S, Peterson, Joseph J, Webber, Beau R, Moriarity, Branden S

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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade von Palmer, Douglas C, Webber, Beau R, Patel, Yogin, Johnson, Matthew J, Kariya, Christine M, Lahr, Walker S, Parkhurst, Maria R, Gartner, Jared J, Prickett, Todd D, Lowery, Frank J, Kishton, Rigel J, Gurusamy, Devikala, Franco, Zulmarie, Vodnala, Suman K, Diers, Miechaleen D, Wolf, Natalie K, Slipek, Nicholas J, McKenna, David H, Sumstad, Darin, Viney, Lydia, Henley, Tom, Bürckstümmer, Tilmann, Baker, Oliver, Hu, Ying, Yan, Chunhua, Meerzaman, Daoud, Padhan, Kartik, Lo, Winnie, Malekzadeh, Parisa, Jia, Li, Deniger, Drew C, Patel, Shashank J, Robbins, Paul F, McIvor, R Scott, Choudhry, Modassir, Rosenberg, Steven A, Moriarity, Branden S, Restifo, Nicholas P

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Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair von Webber, Beau R, Johnson, Matthew J, Skeate, Joseph G, Slipek, Nicholas J, Lahr, Walker S, DeFeo, Anthony P, Mills, Lauren J, Qiu, Xiaohong, Rathmann, Blaine, Diers, Miechaleen D, Wick, Bryce, Henley, Tom, Choudhry, Modassir, Starr, Timothy K, McIvor, R Scott, Moriarity, Branden S

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333 Targeting the apical intracellular checkpoint CISH unleashes T cell neoantigen reactivity and effector program von Palmer, Douglas, Webber, Beau, Patel, Yogin, Johnson, Matthew, Kariya, Christine, Lahr, Walker, Parkhurst, Maria, Gartner, Jared, Prickett, Todd, Lowery, Frank, Kishton, Rigel, Gurusamy, Devikala, Franco, Zulmarie, Vodnala, Suman, Diers, Miechaleen, Wolf, Natalie, Slipek, Nicholas, McKenna, David, Sumstad, Darin, Viney, Lydia, Henley, Tom, Bürckstümmer, Tilmann, Baker, Oliver, Hu, Ying, Yan, Chunhua, Meerzaman, Daoud, Padhan, Kartik, Lo, Winnie, Malekzadeh, Parisa, Jia, Li, Deniger, Drew, Patel, Shashank, Robbins, Paul, Scott McIvor, R, Choudhry, Modassir, Rosenberg, Steven, Moriarity, Branden, Restifo, Nicholas

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3145 – TRANSIENT EXPRESSION OF HEMATOPOIETIC TRANSCRIPTION FACTORS ENHANCES T CELL POTENTIAL OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED HEMATOPOIETIC PROGENITORS von Napiwocki, Brett, Lahr, Walker, Moriarity, Branden, von Dissen, Lage, Webber, Beau

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Abstract A021: Chimeric antigen receptor armored natural killer cell immunotherapy for osteosarcoma von Robbins, Gabrielle, Yamomoto, Kenta, Lahr, Walker, Skeate, Joseph

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