Dose range finding approach for rodent preweaning juvenile animal studies von Posobiec, Lorraine M., Laffan, Susan B.

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Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates von Laffan, Susan B, Thomson, Andrew S, Mai, Shing, Fishman, Cindy, Kambara, Takahito, Nistala, Kiran, Raymond, James T, Chen, Shugui, Ramani, Thulasi, Pageon, Laura, Polsky, Rodd, Watkins, Mark, Ottolangui, Gemma, White, John R, Maier, Curtis, Herdman, Michael, Bouma, Gerben

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Imaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration von Groseclose, M. Reid, Laffan, Susan B., Frazier, Kendall S., Hughes-Earle, Angela, Castellino, Stephen

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Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats von Fishman, Cindy, Caverly Rae, Jessica M, Posobiec, Lorraine M, Laffan, Susan B, Lerman, Steven A, Pearson, Neil, Janmohamed, Salim, Dumont, Etienne, Nunn-Floyd, Deatra, Stanislaus, Dinesh J

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Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety von Ramani, Thulasi, Wange, Ronald L., Manetz, T. Scott, Kruzich, Paul J., Laffan, Susan B., Compton, David R.

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The benefits, limitations and opportunities of preclinical models for neonatal drug development von Campion, Sarah, Inselman, Amy, Hayes, Belinda, Casiraghi, Costanza, Joseph, David, Facchinetti, Fabrizio, Salomone, Fabrizio, Schmitt, Georg, Hui, Julia, Davis-Bruno, Karen, Van Malderen, Karen, Morford, LaRonda, De Schaepdrijver, Luc, Wiesner, Lutz, Kourula, Stephanie, Seo, Suna, Laffan, Susan, Urmaliya, Vijay, Chen, Connie

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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure von Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

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Absence of developmental and reproductive toxicity in animals exposed to dolutegravir von Stanislaus, Dinesh J., Posobiec, Lorraine M., Laffan, Susan B., Solomon, Howard M., Ziejewski, Mary K., Romach, Elizabeth H.

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Species Comparison of Postnatal Development of the Female Reproductive System von Laffan, Susan B., Posobiec, Lorraine M., Uhl, Jenny E., Vidal, Justin D.

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Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation von Posobiec, Lorraine M., Vidal, Justin D., Hughes-Earle, Angela, Laffan, Susan B., Hart, Timothy

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Dihydroartemisinin (DHA) Treatment Causes an Arrest of Cell Division and Apoptosis in Rat Embryonic Erythroblasts in Whole Embryo Culture von Posobiec, Lorraine M., Clark, Robert L., Bushdid, Paul B., Laffan, Susan B., Wang, Kai-Fen, White, Tacey E. K.

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Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo von White, Tacey E.K., Bushdid, Paul B., Ritter, Sandra, Laffan, Susan B., Clark, Robert L.

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Nonclinical Models for Neonatal Pediatric Drug Development von Davis-Bruno, Karen, De Schaepdrijver, Luc, Annaert, Pieter, Campion, Sarah, Carleer, Jacqueline, Chapin, Robert, Harrouk, Wafa, Laffan, Susan B., McCune, S., Moffat, Graeme, Tassinari, M.S., Urmaliya, V., Chen, C.L.

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Assessing a theoretical risk of dolutegravir-induced developmental immunotoxicity in juvenile rats von Rhodes, Melissa, Laffan, Susan, Genell, Caroline, Gower, Jill, Maier, Curtis, Fukushima, Tamio, Nichols, Garrett, Bassiri, Ashlyn Eaton

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GSK Regulatory strategy for non-clinical safety assessment of vaccines intended for maternal immunization von Segal, Lawrence, Giordano, Giulia, Damsten, Micaela, Delannois, Frederique, Destexhe, Eric, Steff, Ann-Muriel, Laffan, Susan, Lammineur, Chantal

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The Inhibin B Response to a Motilin Receptor Agonist in Male Rats: Special Issue on Inhibin B Biomarker Research von ZIEJEWSKI, Mary K, VIDAL, Justin D, STANISLAUS, Dinesh, APOSTOLI, April, CHOWDHURY, Probash, LAFFAN, Susan

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Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects von Theunissen, Peter T, Beken, Sonia, Beyer, Bruce K, Breslin, William J, Cappon, Gregg D, Chen, Connie L, Chmielewski, Gary, de Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E, Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M, Y Hui, Julia, Knudsen, Thomas B, Laffan, Susan B, Makris, Susan L, Martin, Matthew, McNerney, Mary Ellen, Siezen, Christine L E, Stanislaus, Dinesh J, Stewart, Jane, Thompson, Kary E, Tornesi, Belen, Van Der Laan, Jan Willem, Weinbauer, Gerhard F, Wood, Sandra, Piersma, Aldert H

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The Inhibin B Response to a Motilin Receptor Agonist in Male Rats von Ziejewski, Mary K., Vidal, Justin D., Stanislaus, Dinesh, Apostoli, April, Chowdhury, Probash, Laffan, Susan

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Summary of the HESI Consortium Studies Exploring Circulating Inhibin B as a Potential Biomarker of Testis Damage in the Rat: Special Issue on Inhibin B Biomarker Research von CHAPIN, Robert, WEINBAUER, Gerhard, GOLDSTEIN, Richard A, ERDOS, Zoltan, ENRIGHT, Brian P, COULSON, Michelle, BRESLIN, William J, THIBODEAU, Michael S, SONEE, Manisha, SALDUTTI, Louise Parks, REAGAN, William J, POTTER, David, MOFFIT, Jeffrey S, LAFFAN, Susan, KIM, James H

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Summary of the HESI Consortium Studies Exploring Circulating Inhibin B as a Potential Biomarker of Testis Damage in the Rat von Chapin, Robert, Weinbauer, Gerhard, Thibodeau, Michael S., Sonee, Manisha, Saldutti, Louise Parks, Reagan, William J., Potter, David, Moffit, Jeffrey S., Laffan, Susan, Kim, James H., Goldstein, Richard A., Erdos, Zoltan, Enright, Brian P., Coulson, Michelle, Breslin, William J.

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