An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations von Vafa, Omid, Gilliland, Gary L., Brezski, Randall J., Strake, Brandy, Wilkinson, Teresa, Lacy, Eilyn R., Scallon, Bernard, Teplyakov, Alexey, Malia, Thomas J., Strohl, William R.

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Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8 von Malia, Thomas J., Teplyakov, Alexey, Ernst, Robin, Wu, Sheng-Jiun, Lacy, Eilyn R., Liu, Xuesong, Vandermeeren, Marc, Mercken, Marc, Luo, Jinquan, Sweet, Raymond W., Gilliland, Gary L.

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Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections von Buckley, Peter T., Chan, Rita, Fernandez, Jeffrey, Luo, Jinquan, Lacey, Keenan A., DuMont, Ashley L., O’Malley, Aidan, Brezski, Randall J., Zheng, Songmao, Malia, Thomas, Whitaker, Brian, Zwolak, Adam, Payne, Angela, Clark, Desmond, Sigg, Martin, Lacy, Eilyn R., Kornilova, Anna, Kwok, Debra, McCarthy, Steve, Wu, Bingyuan, Morrow, Brian, Nemeth-Seay, Jennifer, Petley, Ted, Wu, Sam, Strohl, William R., Lynch, Anthony Simon, Torres, Victor J.

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Structural Basis for the Dual Recognition of IL-12 and IL-23 by Ustekinumab von Luo, Jinquan, Wu, Sheng-Jiun, Lacy, Eilyn R., Orlovsky, Yevgeniya, Baker, Audrey, Teplyakov, Alexey, Obmolova, Galina, Heavner, George A., Richter, Hans-Thomas, Benson, Jacqueline

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding von Kriwacki, Richard W, Lacy, Eilyn R, Filippov, Igor, Lewis, William S, Otieno, Steve, Xiao, Limin, Weiss, Sonja, Hengst, Ludger

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"Stapling" scFv for multispecific biotherapeutics of superior properties von Boucher, Lauren E, Prinslow, Elisabeth Geyer, Feldkamp, Michael, Yi, Fang, Nanjunda, Rupesh, Wu, Sheng-Jiun, Liu, Tun, Lacy, Eilyn R, Jacobs, Steven, Kozlyuk, Natalia, Del Rosario, Brian, Wu, Bingyuan, Aquino, Patricia, Davidson, Robert C, Heyne, Samantha, Mazzanti, Nicholas, Testa, James, Diem, Michael D, Gorre, Elsa, Mahan, Andrew, Nanda, Hirsh, Gunawardena, Harsha P, Gervais, Alexis, Armstrong, Anthony A, Teplyakov, Alexey, Huang, Chichi, Zwolak, Adam, Chowdhury, Partha, Cheung, Wan Cheung, Luo, Jinquan

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Free sulfhydryl measurement as an indicator of antibody stability von Lacy, Eilyn R., Baker, Margaret, Brigham-Burke, Michael

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Structure-based engineering of a monoclonal antibody for improved solubility von Wu, Sheng-Jiun, Luo, Jinquan, O'Neil, Karyn T., Kang, James, Lacy, Eilyn R., Canziani, Gabriela, Baker, Audrey, Huang, Maggie, Tang, Qing Mike, Raju, T.Shantha, Jacobs, Steven A., Teplyakov, Alexey, Gilliland, Gary L., Feng, Yiqing

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Thrombogenic Collagen-Mimetic Peptides: Self-Assembly of Triple Helix-Based Fibrils Driven by Hydrophobic Interactions von Cejas, Mabel A., Kinney, William A., Chen, Cailin, Vinter, Jeremy G., Almond, Harold R., Balss, Karin M., Maryanoff, Cynthia A., Schmidt, Ute, Breslav, Michael, Mahan, Andrew, Lacy, Eilyn, Maryanoff, Bruce E.

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Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody von Hinke, Simon A., Cieniewicz, Anne M., Kirchner, Thomas, D'Aquino, Katharine, Nanjunda, Rupesh, Aligo, Jason, Perkinson, Robert, Cooper, Philip, Boayke, Ken, Chiu, Mark L., Jarantow, Steve, Lacy, Eilyn R., Liang, Yin, Johnson, Dana L., Whaley, Jean M., Lingham, Russell B., Kihm, Anthony J.

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CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function von Santulli-Marotto, Sandra, Wheeler, John, Lacy, Eilyn R., Boakye, Ken, Luongo, Jennifer, Wu, Sheng-Jiun, Ryan, Mary

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Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae von Luo, Rensheng, Mann, Beth, Lewis, William S, Rowe, Arthur, Heath, Richard, Stewart, Michael L, Hamburger, Agnes E, Sivakolundu, Siva, Lacy, Eilyn R, Bjorkman, Pamela J, Tuomanen, Elaine, Kriwacki, Richard W

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Recognition of T·G mismatched base pairs in DNA by stacked imidazole-containing polyamides: surface plasmon resonance and circular dichroism studies von Lacy, Eilyn R., Cox, Kari K., Wilson, W. David, Lee, Moses

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769 GUSELKUMAB, AN IL-23P19 SUBUNIT-SPECIFIC MONOCLONAL ANTIBODY, BINDS CD64+ MYELOID CELLS AND POTENTLY NEUTRALIZES IL-23 PRODUCED FROM THE SAME CELLS von Abreu, Maria T., Atreya, Raja, Krueger, James G., Eyerich, Kilian, Sachen, Kacey, Greving, Carrie, Hammaker, Deepa, Bao, Phuc, Lacy, Eilyn, Sarabia, Indra, Deming, Janise, Elloso, M. Merle, Ritchlin, Christopher, McInnes, Iain B., Allez, Matthieu, Fourie, Anne

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Negative Regulation of ASK1 by p21Cip1 Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo von Zhan, Jun, Easton, John B., Huang, Shile, Mishra, Ashutosh, Xiao, Limin, Lacy, Eilyn R., Kriwacki, Richard W., Houghton, Peter J.

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Energetic basis for selective recognition of T·G mismatched base pairs in DNA by imidazole‐rich polyamides von Lacy, Eilyn R., Nguyen, Binh, Le, Minh, Cox, Kari K., O’Hare, Caroline, Hartley, John A., Lee, Moses, Wilson, W. David

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Thermodynamic characterization of interactions between p27Kip1 and activated and non-activated Cdk2: Intrinsically unstructured proteins as thermodynamic tethers von Bowman, Prentice, Galea, Charles A., Lacy, Eilyn, Kriwacki, Richard W.

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Thermodynamic characterization of interactions between p27 Kip1 and activated and non-activated Cdk2: Intrinsically unstructured proteins as thermodynamic tethers von Bowman, Prentice, Galea, Charles A., Lacy, Eilyn, Kriwacki, Richard W.

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Negative Regulation of ASK1 by p21 super(Cip1) Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo von Zhan, Jun, Easton, John B, Huang, Shile, Mishra, Ashutosh, Xiao, Limin, Lacy, Eilyn R, Kriwacki, Richard W, Houghton, Peter J

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Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung: e81465 von Santulli-Marotto, Sandra, Boakye, Ken, Lacy, Eilyn, Wu, Sheng-Jiun, Luongo, Jennifer, Kavalkovich, Karl, Coelho, Ana, Hogaboam, Cory M, Ryan, Mary

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