Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant von Spoerke, Jill M., Gendreau, Steven, Walter, Kimberly, Qiu, Jiaheng, Wilson, Timothy R., Savage, Heidi, Aimi, Junko, Derynck, Mika K., Chen, Meng, Chan, Iris T., Amler, Lukas C., Hampton, Garret M., Johnston, Stephen, Krop, Ian, Schmid, Peter, Lackner, Mark R.

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Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy von JIPING ZHA, LACKNER, Mark R

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In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models von HOEFLICH, Klaus P, O'BRIEN, Carol, WEI ZHOU, BERRY, Leanne, MURRAY, Lesley, AMLER, Lukas, BELVIN, Marcia, FRIEDMAN, Lori S, LACKNER, Mark R, BOYD, Zachary, CAVET, Guy, GUERRERO, Steve, JUNG, Kenneth, JANUARIO, Tom, SAVAGE, Heidi, PUNNOOSE, Elizabeth, TRUONG, Tom

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Molecular biomarker analyses using circulating tumor cells von Punnoose, Elizabeth A, Atwal, Siminder K, Spoerke, Jill M, Savage, Heidi, Pandita, Ajay, Yeh, Ru-Fang, Pirzkall, Andrea, Fine, Bernard M, Amler, Lukas C, Chen, Daniel S, Lackner, Mark R

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Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models von O'BRIEN, Carol, WALLIN, Jeffrey J, BEIVIN, Marcia, FRIEDMAN, Lori S, LACKNER, Mark R, SAMPATH, Deepak, GUHATHAKURTA, Debraj, SAVAGE, Heidi, PUNNOOSE, Elizabeth A, GUAN, Jane, BERRY, Leanne, PRIOR, Wei Wei, AMLER, Lukas C

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ERK inhibition overcomes acquired resistance to MEK inhibitors von Hatzivassiliou, Georgia, Liu, Bonnie, O'Brien, Carol, Spoerke, Jill M, Hoeflich, Klaus P, Haverty, Peter M, Soriano, Robert, Forrest, William F, Heldens, Sherry, Chen, Huifen, Toy, Karen, Ha, Connie, Zhou, Wei, Song, Kyung, Friedman, Lori S, Amler, Lukas C, Hampton, Garret M, Moffat, John, Belvin, Marcia, Lackner, Mark R

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TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer von Stinson, Susanna, Lackner, Mark R, Adai, Alex T, Yu, Nancy, Kim, Hyo-Jin, O'Brien, Carol, Spoerke, Jill, Jhunjhunwala, Suchit, Boyd, Zachary, Januario, Thomas, Newman, Robert J, Yue, Peng, Bourgon, Richard, Modrusan, Zora, Stern, Howard M, Warming, Søren, de Sauvage, Frederic J, Amler, Lukas, Yeh, Ru-Fang, Dornan, David

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Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level von Lu, Shan, Chang, Chia-Jung, Guan, Yinghui, Szafer-Glusman, Edith, Punnoose, Elizabeth, Do, An, Suttmann, Becky, Gagnon, Ross, Rodriguez, Angel, Landers, Mark, Spoerke, Jill, Lackner, Mark R., Xiao, Wenzhong, Wang, Yulei

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A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types von Wagle, Marie-Claire, Kirouac, Daniel, Klijn, Christiaan, Liu, Bonnie, Mahajan, Shilpi, Junttila, Melissa, Moffat, John, Merchant, Mark, Huw, Ling, Wongchenko, Matthew, Okrah, Kwame, Srinivasan, Shrividhya, Mounir, Zineb, Sumiyoshi, Teiko, Haverty, Peter M., Yauch, Robert L., Yan, Yibing, Kabbarah, Omar, Hampton, Garret, Amler, Lukas, Ramanujan, Saroja, Lackner, Mark R., Huang, Shih-Min A.

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High-Throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples by Multiplexed PCR and Next-Generation Sequencing von BOURGON, Richard, SHAN LU, PATEL, Rajesh, HAMPTON, Garret M, AMLER, Lukas C, YULEI WANG, YIBING YAN, LACKNER, Mark R, WEIRU WANG, WEIGMAN, Victor, WANG, David, YINGHUI GUAN, RYNER, Lisa, KOEPPEN, Hartmut

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Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes von Hu, Xiaolan, Stern, Howard M, Ge, Lin, O'Brien, Carol, Haydu, Lauren, Honchell, Cynthia D, Haverty, Peter M, Peters, Brock A, Wu, Thomas D, Amler, Lukas C, Chant, John, Stokoe, David, Lackner, Mark R, Cavet, Guy

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Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers von Schleifman, Erica B, Desai, Rupal, Spoerke, Jill M, Xiao, Yuanyuan, Wong, Cheryl, Abbas, Ilma, O'Brien, Carol, Patel, Rajesh, Sumiyoshi, Teiko, Fu, Ling, Tam, Rachel N, Koeppen, Hartmut, Wilson, Timothy R, Raja, Rajiv, Hampton, Garret M, Lackner, Mark R

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Profiling Cancer Gene Mutations in Clinical Formalin‐Fixed, Paraffin‐Embedded Colorectal Tumor Specimens Using Targeted Next‐Generation Sequencing von Zhang, Liangxuan, Chen, Liangjing, Sah, Sachin, Latham, Gary J., Patel, Rajesh, Song, Qinghua, Koeppen, Hartmut, Tam, Rachel, Schleifman, Erica, Mashhedi, Haider, Chalasani, Sreedevi, Fu, Ling, Sumiyoshi, Teiko, Raja, Rajiv, Forrest, William, Hampton, Garret M., Lackner, Mark R., Hegde, Priti, Jia, Shidong

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Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer von O'BRIEN, Carol, CAVET, Guy, LACKNER, Mark R, PANDITA, Ajay, XIAOLAN HU, HAYDU, Lauren, MOHAN, Sankar, TOY, Karen, SANCHEZ RIVERS, Celina, MODRUSAN, Zora, AMLER, Lukas C

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Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer von Zha, Jiping, O'Brien, Carol, Savage, Heidi, Huw, Ling-Yuh, Zhong, Fiona, Berry, Leanne, Lewis Phillips, Gail D, Luis, Elizabeth, Cavet, Guy, Hu, Xiaolan, Amler, Lukas C, Lackner, Mark R

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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers von Kim, Daehwan, Chung, Heekyung, Liu, Wen, Jeong, Kangjin, Ozmen, Tugba Y., Ozmen, Furkan, Rames, Matthew J., Kim, Sangyub, Guo, Xiao, Jameson, Nathan, de Jong, Petrus R., Yea, Steven, Harford, Laurie, Li, Jiali, Mathews, Cara A., Doroshow, Deborah B., Charles, Vincent J., Kim, Doris, Fischer, Kimberlee, Samatar, Ahmed A., Jubb, Adrian, Bunker, Kevin D., Blackwell, Kimberly, Simpkins, Fiona, Meric-Bernstam, Funda, Mills, Gordon B., Harismendy, Olivier, Ma, Jianhui, Lackner, Mark R.

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Development and Application of a Microfluidics-Based Panel in the Basal/Luminal Transcriptional Characterization of Archival Bladder Cancers von Kim, Doris, Choi, YounJeong, Ireland, James, Foreman, Oded, Tam, Rachel N, Patel, Rajesh, Schleifman, Erica B, Motlhabi, Maipelo, French, Dorothy, Wong, Cheryl V, Peters, Eric, Molinero, Luciana, Raja, Rajiv, Amler, Lukas C, Hampton, Garret M, Lackner, Mark R, Kabbarah, Omar

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First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors von Sarker, Debashis, Ang, Joo Ern, Baird, Richard, Kristeleit, Rebecca, Shah, Krunal, Moreno, Victor, Clarke, Paul A, Raynaud, Florence I, Levy, Gallia, Ware, Joseph A, Mazina, Kathryn, Lin, Ray, Wu, Jenny, Fredrickson, Jill, Spoerke, Jill M, Lackner, Mark R, Yan, Yibing, Friedman, Lori S, Kaye, Stan B, Derynck, Mika K, Workman, Paul, de Bono, Johann S

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Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays von Boyd, Zachary S, Wu, Qun Jenny, O'Brien, Carol, Spoerke, Jill, Savage, Heidi, Fielder, Paul J, Amler, Lukas, Yan, Yibing, Lackner, Mark R

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Evaluation of Circulating Tumor Cells and Circulating Tumor DNA in Non―Small Cell Lung Cancer: Association with Clinical Endpoints in a Phase II Clinical Trial of Pertuzumab and Er... von PUNNOOSE, Elizabeth A, ATWAL, Siminder, LACKNER, Mark R, WEIQUN LIU, RAJA, Rajiv, FINE, Bernard M, HUGHES, Brett G. M, HICKS, Rodney J, HAMPTON, Garret M, AMLER, Lukas C, PIRZKALL, Andrea

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