Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening von Guzi, Timothy J, Paruch, Kamil, Dwyer, Michael P, Labroli, Marc, Shanahan, Frances, Davis, Nicole, Taricani, Lorena, Wiswell, Derek, Seghezzi, Wolfgang, Penaflor, Ervin, Bhagwat, Bhagyashree, Wang, Wei, Gu, Danling, Hsieh, Yunsheng, Lee, Suining, Liu, Ming, Parry, David

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Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions von Boger, Dale L, Boyce, Christopher W, Labroli, Marc A, Sehon, Clark A, Jin, Qing

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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets von Mann, Paul A, Müller, Anna, Wolff, Kerstin A, Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E, Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R, Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J, Pinho, Mariana G, Schneider, Tanja, Roemer, Terry

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Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)phenyl}ethyl-3(S)-methyl-1... von Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis, Labroli, Marc A, Xiao, Yushi, Steensma, Ruo W, Strizki, Julie M, Baroudy, Bahige M, Cox, Kathleen, Lachowicz, Jean, Varty, Geoffrey, Watkins, Robert

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase von Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry

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Discovery of potent wall teichoic acid early stage inhibitors von Labroli, Marc A., Caldwell, John P., Yang, Christine, Lee, Sang Ho, Wang, Hao, Koseoglu, Sandra, Mann, Paul, Yang, Shu-Wei, Xiao, Jing, Garlisi, Charles G., Tan, Christopher, Roemer, Terry, Su, Jing

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1 von Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2 von Labroli, Marc, Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Keertikar, Kartik, Poker, Cory, Rossman, Randall, Duca, Jose S., Fischmann, Thierry O., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors von Labroli, Marc A., Dwyer, Michael P., Shen, Ruichao, Popovici-Muller, Janeta, Pu, Qinglin, Wyss, Daniel, McCoy, Mark, Barrett, Dianah, Davis, Nicole, Seghezzi, Wolfgang, Shanahan, Frances, Taricani, Lorena, Beaumont, Maribel, Malinao, Maria-Christina, Parry, David, Guzi, Timothy J.

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The synthesis of amino-acid functionalized β-Carbolines as topoisomerase II inhibitors von Deveau, Amy Morin, Labroli, Marc A, Dieckhaus, Christine M, Barthen, Mary T, Smith, Kirsten S, Macdonald, Timothy L

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A convergent preparation of the CHK1 inhibitor MK-8776 (SCH 900776) von Labroli, Marc A., Dwyer, Michael P., Poker, Cory, Keertikar, Kerry M., Rossman, Randall, Guzi, Timothy J.

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Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery von Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning

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Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy von Skudlarek, Jason W, Cooke, Andrew J, Mitchell, Helen J, Babaoglu, Kerim, Shaw, Anthony W, Tong, Ling, Nomland, Ashley B, Labroli, Marc, Sha, Deyou, Mulhearn, James J, Wu, Chengwei, Li, Sarah W, Beshore, Douglas C, Hughes, Jonathan M E, Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J, Painter, Ronald E, Shen, Pamela, Lange, Henry S, Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J, Tracy, Rodger W, Miller, Randy R, Cabalu, Tamara D, Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W, Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F, Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V, Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K Y, Hennig, Michael, Raheem, Izzat, Walker, Scott S

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles von Sanders, John M, Beshore, Douglas C, Culberson, J Christopher, Fells, James I, Imbriglio, Jason E, Gunaydin, Hakan, Haidle, Andrew M, Labroli, Marc, Mattioni, Brian E, Sciammetta, Nunzio, Shipe, William D, Sheridan, Robert P, Suen, Linda M, Verras, Andreas, Walji, Abbas, Joshi, Elizabeth M, Bueters, Tjerk

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Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure–Activity Relationships von Plotkin, Michael A., Labroli, Marc, Schubert, Jeffrey, Shaw, Anthony, Schlegel, Kelly-Ann S., Berger, Richard, Cooke, Andrew J., Hayes, Robert P., Armacost, Kira A., Kinek, Keith, Krosky, Paula, Burlein, Christine, Meng, Shi, DiNunzio, Edward, Murray, Edward M., Agrawal, Sony, Madeira, Maria, Flattery, Amy, Yao, Huifang, Leithead, Andrew, Rose, William A, Cox, Christopher, Tellers, David M., McKenna, Philip M., Raheem, Izzat

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS von Berejnaia, Olga, Wang, Hao, Labroli, Marc, Yang, Christine, Gill, Charles, Xiao, Jianying, Hesk, David, DeJesus, Reynalda, Su, Jing, Tan, Christopher M., Sheth, Payal R., Kavana, Michael, McLaren, David G.

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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus von Yang, Shu-Wei, Pan, Jianping, Yang, Christine, Labroli, Marc, Pan, Weidong, Caldwell, John, Ha, Sookhee, Koseoglu, Sandra, Xiao, Jing C., Mayhood, Todd, Sheth, Payal R., Garlisi, Charles G., Wu, Jin, Lee, Sang Ho, Wang, Hao, Tan, Christopher M., Roemer, Terry, Su, Jing

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Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach von Dwyer, Michael P., Keertikar, Kartik, Paruch, Kamil, Alvarez, Carmen, Labroli, Marc, Poker, Cory, Fischmann, Thierry O., Mayer-Ezell, Rosemary, Bond, Richard, Wang, Yan, Azevedo, Rita, Guzi, Timothy J.

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor von Mandal, Mihirbaran, Tan, Zheng, Madsen-Duggan, Christina, Buevich, Alexei V, Caldwell, John P, Dejesus, Reynalda, Flattery, Amy, Garlisi, Charles G, Gill, Charles, Ha, Sookhee Nicole, Ho, Ginny, Koseoglu, Sandra, Labroli, Marc, Basu, Kallol, Lee, Sang Ho, Liang, Lianzhu, Liu, Jenny, Mayhood, Todd, McGuinness, Debra, McLaren, David G, Wen, Xiujuan, Parmee, Emma, Rindgen, Diane, Roemer, Terry, Sheth, Payal, Tawa, Paul, Tata, James, Yang, Christine, Yang, Shu-Wei, Xiao, Li, Wang, Hao, Tan, Christopher, Tang, Haifeng, Walsh, Paul, Walsh, Erika, Wu, Jin, Su, Jing

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-ddacthf) : A potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine... von MARSILJE, Thomas H, LABROLI, Marc A, WILSON, Ian A, BEARDSLEY, G. Peter, BENKOVIC, Stephen J, BOGER, Dale L, HEDRICK, Michael P, QING JIN, DESHARNAIS, Joel, BAKER, Stephen J, GOOLJARSINGH, Lata T, RAMCHARAN, Joseph, TAVASSOLI, Ali, YAN ZHANG

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