Bispecific antibodies: a mechanistic review of the pipeline von Labrijn, Aran F., Janmaat, Maarten L., Reichert, Janice M., Parren, Paul W. H. I.

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Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors von Middelburg, Jim, Kemper, Kristel, Engelberts, Patrick, Labrijn, Aran F, Schuurman, Janine, van Hall, Thorbald

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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen von Wang, Guanbo, de Jong, Rob N., van den Bremer, Ewald T.J., Beurskens, Frank J., Labrijn, Aran F., Ugurlar, Deniz, Gros, Piet, Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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FcγR Binding and ADCC Activity of Human IgG Allotypes von de Taeye, Steven W, Bentlage, Arthur E H, Mebius, Mirjam M, Meesters, Joyce I, Lissenberg-Thunnissen, Suzanne, Falck, David, Sénard, Thomas, Salehi, Nima, Wuhrer, Manfred, Schuurman, Janine, Labrijn, Aran F, Rispens, Theo, Vidarsson, Gestur

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange von Labrijn, Aran F, Meesters, Joyce I, de Goeij, Bart E C G, van den Bremer, Ewald T J, Neijssen, Joost, van Kampen, Muriel D, Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J, van Berkel, Patrick H C, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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Impact of structural modifications of IgG antibodies on effector functions von Damelang, Timon, Brinkhaus, Maximilian, van Osch, Thijs L J, Schuurman, Janine, Labrijn, Aran F, Rispens, Theo, Vidarsson, Gestur

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Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding von Frischauf, Nikolaus, Strasser, Jürgen, Borg, Ellen G F, Labrijn, Aran F, Beurskens, Frank J, Preiner, Johannes

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The Influence of Human IgG Subclass and Allotype on Complement Activation von Damelang, Timon, de Taeye, Steven W, Rentenaar, Rosa, Roya-Kouchaki, Kasra, de Boer, Esther, Derksen, Ninotska I L, van Kessel, Kok, Lissenberg-Thunnissen, Suzanne, Rooijakkers, Suzan H M, Jongerius, Ilse, Mebius, Mirjam M, Schuurman, Janine, Labrijn, Aran F, Vidarsson, Gestur, Rispens, Theo

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CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory von Benonisson, Hreinn, Altıntaş, Işıl, Sluijter, Marjolein, Verploegen, Sandra, Labrijn, Aran F, Schuurhuis, Danita H, Houtkamp, Mischa A, Verbeek, J Sjef, Schuurman, Janine, van Hall, Thorbald

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Mutation of the TGN1412 anti‐CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super‐agonist activity von Chenoweth, Alicia M, Esparon, Sandra, Wines, Bruce D, Schuurman, Janine, Labrijn, Aran F, Hogarth, P Mark

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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing von Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry von Rose, Rebecca J., Labrijn, Aran F., van den Bremer, Ewald T.J., Loverix, Stefan, Lasters, Ignace, van Berkel, Patrick H.C., van de Winkel, Jan G.J., Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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Controlled Fab-arm exchange for the generation of stable bispecific IgG1 von Labrijn, Aran F, Meesters, Joyce I, Priem, Patrick, de Jong, Rob N, van den Bremer, Ewald T J, van Kampen, Muriel D, Gerritsen, Arnout F, Schuurman, Janine, Parren, Paul W H I

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Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models von Labrijn, Aran F., Meesters, Joyce I., Bunce, Matthew, Armstrong, Anthony A., Somani, Sandeep, Nesspor, Tom C., Chiu, Mark L., Altintaş, Işil, Verploegen, Sandra, Schuurman, Janine, Parren, Paul W. H. I.

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In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation von Seshasayee, Dhaya, Lee, Wyne P, Zhou, Meijuan, Shu, Jean, Suto, Eric, Zhang, Juan, Diehl, Laurie, Austin, Cary D, Meng, Y Gloria, Tan, Martha, Bullens, Sherron L, Seeber, Stefan, Fuentes, Maria E, Labrijn, Aran F, Graus, Yvo M F, Miller, Lisa A, Schelegle, Edward S, Hyde, Dallas M, Wu, Lawren C, Hymowitz, Sarah G, Martin, Flavius

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo von Parren, Paul W H I, Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine, van de Winkel, Jan G J

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Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1 von Labrijn, Aran F, Poignard, Pascal, Raja, Aarti, Zwick, Michael B, Delgado, Karla, Franti, Michael, Binley, James, Vivona, Veronique, Grundner, Christoph, Huang, Chih-Chin, Venturi, Miro, Petropoulos, Christos J, Wrin, Terri, Dimitrov, Dimiter S, Robinson, James, Kwong, Peter D, Wyatt, Richard T, Sodroski, Joseph, Burton, Dennis R

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Hitting Ebola, to the power of two von Labrijn, Aran F., Parren, Paul W. H. I.

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Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity von Gammelgaard, Odd L, Terp, Mikkel G, Renn, Christian, Labrijn, Aran F, Hamaker, Oliver, Nielsen, Aaraby Y, Vever, Henriette, Hansen, Soren WK, Gjerstorff, Morten F, Müller, Christa E, Parren, Paul WHI, Ditzel, Henrik J

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Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength von Labrijn, Aran F, Rispens, Theo, Meesters, Joyce, Rose, Rebecca J, den Bleker, Tamara H, Loverix, Stefan, van den Bremer, Ewald T J, Neijssen, Joost, Vink, Tom, Lasters, Ignace, Aalberse, Rob C, Heck, Albert J R, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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