Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors von Middelburg, Jim, Kemper, Kristel, Engelberts, Patrick, Labrijn, Aran F., Schuurman, Janine, van Hall, Thorbald

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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen von Wang, Guanbo, de Jong, Rob N., van den Bremer, Ewald T.J., Beurskens, Frank J., Labrijn, Aran F., Ugurlar, Deniz, Gros, Piet, Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange von Labrijn, Aran F, Meesters, Joyce I, de Goeij, Bart E C G, van den Bremer, Ewald T J, Neijssen, Joost, van Kampen, Muriel D, Strumane, Kristin, Verploegen, Sandra, Kundu, Amitava, Gramer, Michael J, van Berkel, Patrick H C, van de Winkel, Jan G J, Schuurman, Janine, Parren, Paul W H I

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The Influence of Human IgG Subclass and Allotype on Complement Activation von Damelang, Timon, de Taeye, Steven W, Rentenaar, Rosa, Roya-Kouchaki, Kasra, de Boer, Esther, Derksen, Ninotska I L, van Kessel, Kok, Lissenberg-Thunnissen, Suzanne, Rooijakkers, Suzan H M, Jongerius, Ilse, Mebius, Mirjam M, Schuurman, Janine, Labrijn, Aran F, Vidarsson, Gestur, Rispens, Theo

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CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory von Benonisson, Hreinn, Altıntaş, Işıl, Sluijter, Marjolein, Verploegen, Sandra, Labrijn, Aran F, Schuurhuis, Danita H, Houtkamp, Mischa A, Verbeek, J Sjef, Schuurman, Janine, van Hall, Thorbald

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Mutation of the TGN1412 anti‐CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super‐agonist activity von Chenoweth, Alicia M, Esparon, Sandra, Wines, Bruce D, Schuurman, Janine, Labrijn, Aran F, Hogarth, P Mark

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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing von Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry von Rose, Rebecca J., Labrijn, Aran F., van den Bremer, Ewald T.J., Loverix, Stefan, Lasters, Ignace, van Berkel, Patrick H.C., van de Winkel, Jan G.J., Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

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Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models von Labrijn, Aran F., Meesters, Joyce I., Bunce, Matthew, Armstrong, Anthony A., Somani, Sandeep, Nesspor, Tom C., Chiu, Mark L., Altintaş, Işil, Verploegen, Sandra, Schuurman, Janine, Parren, Paul W. H. I.

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In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation von Seshasayee, Dhaya, Lee, Wyne P, Zhou, Meijuan, Shu, Jean, Suto, Eric, Zhang, Juan, Diehl, Laurie, Austin, Cary D, Meng, Y Gloria, Tan, Martha, Bullens, Sherron L, Seeber, Stefan, Fuentes, Maria E, Labrijn, Aran F, Graus, Yvo M F, Miller, Lisa A, Schelegle, Edward S, Hyde, Dallas M, Wu, Lawren C, Hymowitz, Sarah G, Martin, Flavius

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo von Parren, Paul W H I, Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine, van de Winkel, Jan G J

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Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1 von Labrijn, Aran F, Poignard, Pascal, Raja, Aarti, Zwick, Michael B, Delgado, Karla, Franti, Michael, Binley, James, Vivona, Veronique, Grundner, Christoph, Huang, Chih-Chin, Venturi, Miro, Petropoulos, Christos J, Wrin, Terri, Dimitrov, Dimiter S, Robinson, James, Kwong, Peter D, Wyatt, Richard T, Sodroski, Joseph, Burton, Dennis R

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Hitting Ebola, to the power of two von Labrijn, Aran F., Parren, Paul W. H. I.

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Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys von Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.

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Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecifi... von van den Bremer, Ewald T. J, Labrijn, Aran F, van den Boogaard, Ramon, Priem, Patrick, Scheffler, Kai, Melis, Joost P. M, Schuurman, Janine, Parren, Paul W. H. I, de Jong, Rob N

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Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41 von Zwick, M B, Labrijn, A F, Wang, M, Spenlehauer, C, Saphire, E O, Binley, J M, Moore, J P, Stiegler, G, Katinger, H, Burton, D R, Parren, P W

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Opening the door to innovation von Schuurman, Janine, Graus, Yvo F, Labrijn, Aran F, Ruuls, Sigrid R, Parren, Paul WHI

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A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunog... von Zwick, Michael B, Kelleher, Robert, Jensen, Richard, Labrijn, Aran F, Wang, Meng, Quinnan, Jr, Gerald V, Parren, Paul W H I, Burton, Dennis R

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Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope von Darbha, Ramalakshmi, Phogat, Sanjay, Labrijn, Aran F, Shu, Yuuei, Gu, Yijun, Andrykovitch, Michelle, Zhang, Mei-Yun, Pantophlet, Ralph, Martin, Loic, Vita, Claudio, Burton, Dennis R, Dimitrov, Dimiter S, Ji, Xinhua

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The Influence of Human IgG Subclass and Allotype on Complement Activation von Damelang, Timon, de Taeye, Steven W, Rentenaar, Rosa, Roya-Kouchaki, Kasra, de Boer, Esther, Derksen, Ninotska I L, van Kessel, Kok, Lissenberg-Thunnissen, Suzanne, Rooijakkers, Suzan H M, Jongerius, Ilse, Mebius, Mirjam M, Schuurman, Janine, Labrijn, Aran F, Vidarsson, Gestur, Rispens, Theo

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