RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients von Venken, Koen, Jacques, Peggy, Mortier, Céline, Labadia, Mark E., Decruy, Tine, Coudenys, Julie, Hoyt, Kathleen, Wayne, Anita L., Hughes, Robert, Turner, Michael, Van Gassen, Sofie, Martens, Liesbet, Smith, Dustin, Harcken, Christian, Wahle, Joseph, Wang, Chao-Ting, Verheugen, Eveline, Schryvers, Nadia, Varkas, Gaëlle, Cypers, Heleen, Wittoek, Ruth, Piette, Yves, Gyselbrecht, Lieve, Van Calenbergh, Serge, Van den Bosch, Filip, Saeys, Yvan, Nabozny, Gerald, Elewaut, Dirk

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Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats von van Tok, Melissa N, Mandour, Mohamed, Wahle, Joseph, Labadia, Mark E, van de Sande, Marleen G H, Nabozny, Gerald, Baeten, Dominique L, van Duivenvoorde, Leonie M

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORγt von Yang, Jianfei, Yang, Min, Htut, Tin Min, Ouyang, Xinshou, Hanidu, Adedayo, Li, Xiang, Sellati, Rosemarie, Jiang, Huiping, Zhang, Shu, Li, Hongxing, Zhao, Jie, Ting, Adrian T, Mayer, Lloyd, Unkeless, Jay C, Labadia, Mark E, Hodge, Martin, Li, Jun, Xiong, Huabao

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Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors von Li, Xiang, Anderson, Marie, Collin, Delphine, Muegge, Ingo, Wan, John, Brennan, Debra, Kugler, Stanley, Terenzio, Donna, Kennedy, Charles, Lin, Siqi, Labadia, Mark E., Cook, Brian, Hughes, Robert, Farrow, Neil A.

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Involvement of GATA3 in Protein Kinase C θ‐induced Th2 cytokine expression von Stevens, Lisa, Htut, Tin M., White, Della, Li, Xiang, Hanidu, Adedayo, Stearns, Carol, Labadia, Mark E., Li, Jun, Brown, Maryanne, Yang, Jianfei

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High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization von Pullen, Steven S, Labadia, Mark E, Ingraham, Richard H, McWhirter, Sarah M, Everdeen, Daniel S, Alber, Tom, Crute, James J, Kehry, Marilyn R

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Molecular Regulation of the Interaction Between Leukocyte Function-Associated Antigen-1 and Soluble ICAM-1 by Divalent Metal Cations von Labadia, Mark E, Jeanfavre, Deborah Durham, Caviness, Gary O, Morelock, Maurice M

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Discovery and Characterization of a Substrate Selective p38α Inhibitor von Davidson, Walter, Frego, Lee, Peet, Gregory W, Kroe, Rachel R, Labadia, Mark E, Lukas, Susan M, Snow, Roger J, Jakes, Scott, Grygon, Christine A, Pargellis, Christopher, Werneburg, Brian G

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors von Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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Catalysis and Function of the p38α·MK2a Signaling Complex von Lukas, Susan M, Kroe, Rachel R, Wildeson, Jessi, Peet, Gregory W, Frego, Lee, Davidson, Walter, Ingraham, Richard H, Pargellis, Christopher A, Labadia, Mark E, Werneburg, Brian G

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The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1 von CAUINESS, Gary O, LABADIA, Mark E, GIBLIN, Patricia A, WOSKA, Joseph R, LAST-BARNEY, Kathleen, JEANFAVRE, Deborah D, MORELOCK, Maurice M

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Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor von Kroe, Rachel R., Baker, Martha A., Brown, Martha P., Farrow, Neil A., Gautschi, Elda, Hopkins, Jerry L., LaFrance, Roger R., Kronkaitis, Anthony, Freeman, Dorothy, Thomson, David, Nabozny, Gerald, Grygon, Christine A., Labadia, Mark E.

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Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors von Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.

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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients von Venken, Koen, Jacques, Peggy, Mortier, Céline, Labadia, Mark E, Decruy, Tine, Coudenys, Julie, Hoyt, Kathleen, Wayne, Anita L, Hughes, Robert, Turner, Michael, Van Gassen, Sofie, Martens, Liesbet, Smith, Dustin, Harcken, Christian, Wahle, Joseph, Wang, Chao-Ting, Verheugen, Eveline, Schryvers, Nadia, Varkas, Gaëlle, Cypers, Heleen, Wittoek, Ruth, Piette, Yves, Gyselbrecht, Lieve, Van Calenbergh, Serge, Van den Bosch, Filip, Saeys, Yvan, Nabozny, Gerald, Elewaut, Dirk

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The design of potent hydrazones and disulfides as cathepsin S inhibitors von Cywin, Charles L, Firestone, Raymond A, McNeil, Daniel W, Grygon, Christine A, Crane, Kathryn M, White, Della M, Kinkade, Peter R, Hopkins, Jerry L, Davidson, Walter, Labadia, Mark E, Wildeson, Jessi, Morelock, Maurice M, Peterson, Jeffrey D, Raymond, Ernest L, Brown, Maryanne L, Spero, Denice M

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors von Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Girardot, Marc, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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A synthetic peptide containing a predominant protein kinase C site within p47phox inhibits the NADPH oxidase in intact neutrophils von Labadia, Mark E., Zu, You‐Li, Huang, Chi‐Kuang

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The determination and correlation of molecular and cellular equilibrium Kd and kinetic k(off) values for small molecule allosteric antagonists of LFA-1 von Caviness, Gary O, Labadia, Mark E, Giblin, Patricia A, Woska, Jr, Joseph R, Last-Barney, Kathleen, Jeanfavre, Deborah D, Morelock, Maurice M

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t von Yang, Jianfei, Yang, Min, Htut, Tin Min, Ouyang, Xinshou, Hanidu, Adedayo, Li, Xiang, Sellati, Rosemarie, Jiang, Huiping, Zhang, Shu, Li, Hongxing, Zhao, Jie, Ting, Adrian T, Mayer, Lloyd, Unkeless, Jay C, Labadia, Mark E, Hodge, Martin, Li, Jun, Xiong, Huabao

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Activation of MAP Kinase-Activated Protein Kinase 2 in Human Neutrophils After Phorbol Ester or fMLP Peptide Stimulation von Zu, You-Li, Ai, Youxi, Gilchrist, Annette, Labadia, Mark E., Sha’afi, Ramadan I., Huang, Chi-Kuang

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