Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides:  Adduct Characterization and Avoidance von Capaldi, Daniel C, Gaus, Hans, Krotz, Achim H, Arnold, Jim, Carty, Ricaldo L, Moore, Max N, Scozzari, Anthony N, Lowery, Kirsten, Cole, Douglas L, Ravikumar, Vasulinga T

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A novel solid support for synthesis of oligonucleotide 3′-phosphorothioate monoesters von Cheruvallath, Zacharia S, Cole, Douglas L, Ravikumar, Vasulinga T

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Determination of free and encapsulated oligonucleotides in liposome formulated drug product von Chen, Danhua, Cole, Douglas L, Srivatsa, G.Susan

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Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control von Ravikumar, Vasulinga T, Cole, Douglas L

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Large-scale purification of antisense oligonucleotides by high-performance membrane adsorber chromatography von Deshmukh, Ranjit R, Warner, Timothy N, Hutchison, Fred, Murphy, Michael, Leitch II, William E, De Leon, Patricia, Srivatsa, G.Susan, Cole, Douglas L, Sanghvi, Yogesh S

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Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide s... von Ravikumar, Vasulinga T, Capaldi, Daniel C, Lima, Walt F, Lesnik, Elena, Turney, Brett, Cole, Douglas L

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Applications of green chemistry in the manufacture of oligonucleotide drugs von Sanghvi, Yogesh S., Ravikumar, V. T., Scozzari, Anthony N., Cole, Douglas L.

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Controlled Detritylation of Antisense Oligonucleotides von Krotz, Achim H, McElroy, Bethany, Scozzari, Anthony N, Cole, Douglas L, Ravikumar, Vasulinga T

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Synthesis of Antisense Oligonucleotides:  Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reag... von Cheruvallath, Zacharia S, Carty, Recaldo L, Moore, Max N, Capaldi, Daniel C, Krotz, Achim H, Wheeler, Patrick D, Turney, Brett J, Craig, Stephen R, Gaus, Hans J, Scozzari, Anthony N, Cole, Douglas L, Ravikumar, Vasulinga T

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Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents von Krotz, A H, Cole, D L, Ravikumar, V T

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Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1:  Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation von Ravikumar, Vasulinga T, Kumar, R. Krishna, Capaldi, Daniel C, Turney, Brett, Rentel, Claus, Cole, Douglas L

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On the formation of longmers in phosphorothioate oligodeoxyribonucleotide synthesis von Krotz, Achim H., Klopchin, Patrick G., Walker, Kathleen L., Srivatsa, G.Susan, Cole, Douglas L., Ravikumar, Vasulinga T.

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Selectivity of anion exchange chromatography and capillary gel electrophoresis for the analysis of phosphorothioate oligonucleotides von Srivatsa, G.Susan, Klopchin, Patrick, Batt, Micheal, Feldman, Maria, Carlson, Ronald H, Cole, Douglas L

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Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides:  Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time von Cheruvallath, Zacharia S, Carty, Recaldo L, Andrade, Mark, Moore, Max N, Song, Quinlai, Rentel, Claus, Cole, Douglas L, Ravikumar, Vasulinga T

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Application of sample displacement techniques to the purification of synthetic oligonucleotides and nucleic acids: a mini-review with experimental results von Deshmukh, Ranjit R, Leitch II, William E, Cole, Douglas L

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Pyridinium Trifluoroacetate/N-Methylimidazole as an Efficient Activator for Oligonucleotide Synthesis via the Phosphoramidite Method von Eleuteri, Alessandra, Capaldi, Daniel C, Krotz, Achim H, Cole, Douglas L, Ravikumar, Vasulinga T

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Large-Scale Synthesis of Antisense Oligonucleotides without Chlorinated Solvents von Krotz, Achim H, Carty, Recaldo L, Scozzari, Anthony N, Cole, Douglas L, Ravikumar, Vasulinga T

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Is It Essential to Use Anhydrous Acetonitrile in the Manufacture of Phosphorothioate Oligonucleotides? von Capaldi, Daniel C, Scozzari, Anthony N, Cole, Douglas L, Ravikumar, Vasulinga T

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Quantitative capillary gel electrophoresis assay of phosphorothioate oligonucleotides in pharmaceutical formulations von Srivatsa, G.Susan, Batt, Michael, Schuette, Jodi, Carlson, Ronald H., Fitchett, Jonathan, Lee, Claudia, Cole, Douglas L.

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Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages von Capaldi, D C, Cole, D L, Ravikumar, V T

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