Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles von Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy

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Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors von Corbeil, Christopher R, Englebienne, Pablo, Yannopoulos, Constantin G, Chan, Laval, Das, Sanjoy K, Bilimoria, Darius, L’Heureux, Lucille, Moitessier, Nicolas

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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores von Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency von Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus von Bedard, J, May, S, L'Heureux, L, Stamminger, T, Copsey, A, Drach, J, Huffman, J, Chan, L, Jin, H, Rando, R F

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b von Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers von Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors von Giroux, Simon, Xu, Jinwang, Reddy, T. Jagadeeswar, Morris, Mark, Cottrell, Kevin M, Cadilhac, Caroline, Henderson, James A, Nicolas, Oliver, Bilimoria, Darius, Denis, Francois, Mani, Nagraj, Ewing, Nigel, Shawgo, Rebecca, L’Heureux, Lucille, Selliah, Subajini, Chan, Laval, Chauret, Nathalie, Berlioz-Seux, Francoise, Namchuk, Mark N, Grillot, Anne-Laure, Bennani, Youssef L, Das, Sanjoy K, Maxwell, John P

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Mechanism of Action and In Vitro Activity of 1′,3′-Dioxolanylpurine Nucleoside Analogues against Sensitive and Drug-Resistant Human Immunodeficiency Virus Type 1 Variants von Gu, Z, Wainberg, M A, Nguyen-Ba, N, L'Heureux, L, de Muys, J M, Bowlin, T L, Rando, R F

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C sub(2)-Symmetric inhibitors with diyne and biphenyl linkers von Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M, Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A, L'Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, TJagadeeswar, Selliah, Subajini, Shawgo, Rebecca S, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C, Das, Sanjoy K, Grillot, Anne-Laure, Bennani, Youssef L, Maxwell, John P

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides von Chan, Laval, Pereira, Oswy, Reddy, T.Jagadeeswar, Das, Sanjoy K., Poisson, Carl, Courchesne, Marc, Proulx, Mélanie, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Roy, Caroline, Nasturica, Daniel, Moinet, Christophe, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Courtemanche-Asselin, Philippe, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides von Chan, Laval, Das, Sanjoy K., Reddy, T.Jagadeeswar, Poisson, Carl, Proulx, Mélanie, Pereira, Oswy, Courchesne, Marc, Roy, Caroline, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Labrecque, Denis, Bethell, Richard, Hamel, Martine, Courtemanche-Asselin, Philippe, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean

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Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase von Chan, Laval, Reddy, T. Jagadeeswar, Proulx, Mélanie, Das, Sanjoy K, Pereira, Oswy, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G, Poisson, Carl, Turcotte, Nathalie, Drouin, Alexandre, Alaoui-Ismaili, M. Hicham, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, Bilimoria, Darius, Nguyen-Ba, Nghe

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HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY von YANNOPOULOS, Constantin G, PING XU, PROULX, Melanie, HALAB, Lilianne, WUYI WANG, BEDARD, Jean, MORIN, Nicolas, HAMEL, Martine, NICOLAS, Olivier, BILIMORIA, Darius, L'HEUREUX, Lucille, BETHELL, Richard, FENG NI, DIONNE, Gervais, CHAN, Laval, PEREIRA, Oswy Z, JAGADEESWAR REDDY, T, DAS, Sanjoy K, POISSON, Carl, NGUYEN-BA, Nghe, TURCOTTE, Nathalie

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Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase von Reddy, T.Jagadeeswar, Chan, Laval, Turcotte, Nathalie, Proulx, Melanie, Pereira, Oswy Z., Das, Sanjoy K., Siddiqui, Arshad, Wang, Wuyi, Poisson, Carl, Yannopoulos, Constantin G., Bilimoria, Darius, L'Heureux, Lucille, Alaoui, Hicham M.A., Nguyen-Ba, Nghe

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Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of F itted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors von Corbeil, Christopher R., Englebienne, Pablo, Yannopoulos, Constantin G., Chan, Laval, Das, Sanjoy K., Bilimoria, Darius, L’Heureux, Lucille, Moitessier, Nicolas

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ChemInform Abstract: Docking Ligands into Flexible and Solvated Macromolecules. Part 2. Development and Application of FITTED 1.5 to the Virtual Screening of Potential HCV Polymera... von Corbeil, Christopher R., Englebienne, Pablo, Yannopoulos, Constantin G., Chan, Laval, Das, Sanjoy K., Bilimoria, Darius, L'Heureux, Lucille, Moitessier, Nicolas

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Anti-HIV-1 Activities of 1,3-Dioxolane Guanine and 2,6-Diaminopurine Dioxolane von Gu, Zhengxian, Wainberg, Mark A., Nguyen-ba, Paul, L'Heureux, Lucille, Muys, Jean-Marc De, Rando, Robert F.

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