P409: BCL‐2/BCL‐XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53‐MUTATED ACUTE MYELOID LEUKEMIA von Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein‐Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika

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P562: CAPILLARY BLOOD SAMPLING ALLOWS FEASIBLE METHOD FOR VENETOCLAX CONCENTRATION MEASUREMENT IN AN ACADEMIC MULTICENTER CLINICAL TRIAL CONTEXT von Kytölä, Sari, Vänttinen, Ida, Kuusanmäki, Heikki, Ruokoranta, Tanja, Kurkela, Mika, Kiiski, Johanna, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä‐Remes, Maija, Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, T. Backman, Janne, Niemi, Mikko, Kontro, Mika

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Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia von Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

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Robust scoring of selective drug responses for patient-tailored therapy selection von Chen, Yingjia, He, Liye, Ianevski, Aleksandr, Ayuda-Durán, Pilar, Potdar, Swapnil, Saarela, Jani, Miettinen, Juho J., Kytölä, Sari, Miettinen, Susanna, Manninen, Mikko, Heckman, Caroline A., Enserink, Jorrit M., Wennerberg, Krister, Aittokallio, Tero

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Targeting Venetoclax Resistance in TP53-Mutated Acute Myeloid Leukemia von Vänttinen, Ida, Ruokoranta, Tanja, Saad, Joseph J, Kytölä, Sari, Hellesøy, Monica, Gullaksen, Stein-Erik, Ettala, Pia-Sofia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Wennerberg, Krister, Gjertsen, Bjorn T., Heckman, Caroline A., Kontro, Mika, Kuusanmäki, Heikki

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Ex Vivo Drug Sensitivity Testing to Predict Response to Venetoclax + Azacitidine in Acute Myeloid Leukemia: Interim Results of the Prospective Multicenter Phase II Venex Trial von Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ranta, Amanda, Ruokoranta, Tanja, Holopainen, Annasofia, Koskela, Sirpa, Kuusisto, Milla E.L., Porkka, Kimmo, Räty, Riikka, Västrik, Imre, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

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Aspariginase-Triggered Hyperglycerimedia: An Analysis on Germline Regulatory Gene Variations in Adult Acute Lymphoblastic Leukemia Patients von Kytölä, Sari, Rantamo, Suvi, Jauhiainen, Matti, Porkka, Kimmo, Kilpivaara, Outi, Wartiovaara-Kautto, Ulla

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Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax von Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Ranta, Amanda, Suvela, Minna, Parsons, Alun, Västrik, Imre, Siitonen, Sanna M., Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, Kuusanmäki, Heikki, Kontro, Mika

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Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling von Malani, Disha, Kumar, Ashwini, Yadav, Bhagwan, Kontro, Mika, Potdar, Swapnil, Brück, Oscar, Kytölä, Sari, Saarela, Jani, Eldfors, Samuli, Ojamies, Poojitha, Riikka, Karjalainen, Majumder, Muntasir Mamun, Västrik, Imre, Ellonen, Pekka, Kankainen, Matti, Suvela, Minna, Knappila, Siv, Parson, Alun, Palva, Aino, Mattila, Pirkko, Kulesskiy1, Evgeny, Turunen, Laura, Laamanen, Karoliina, Lehtinen, Elina, Mikkonen, Piia, Nurmi, Maria, Timonen, Sanna, Murumägi, Astrid, Gjersten, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Anders, Simon, Wolf, Maija, Heckman, Caroline, Porkka, Kimmo, Kallioniemi, Olli

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Abstract 458: Precision systems medicine in acute myeloid leukemia: real-time translation of tailored therapeutic opportunities arising from ex-vivo drug sensitivity testing and mo... von Malani, Disha, Kumar, Ashwni, Yadav, Bhagwan, Kontro, Mika, Potdar, Swapnil, Bruck, Oscar, Kytölä, Säri, Saarela, Jani, Eldfors, Samuli, Karjalainen, Riikka, Majumder, Muntasir M., Västrik, Imre, Ellonen, Pekka, Kankainen, Matti, Suvela, Minna, Knappila, Siv, Parson, Alun, Palva, Aino, Mattila, Pirkko, Kulesskiy, Evgeny, Turunen, Laura, Laamanen, Karoliina, Lehtinen, Elina, Nurmi, Maria, Suomi, Katja, Muruimägi, Astrid, Gjertsen, Bjorn T., Mustjoki, Satu, Anders, Simon, Wolf, Maija, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline, Porkka, Kimmo, Kallioniemi, Olli

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Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TED... von Lindfors, Katri, Lin, Jake, Lee, Hye-Seung, Hyöty, Heikki, Nykter, Matti, Kurppa, Kalle, Liu, Edwin, Koletzko, Sibylle, Rewers, Marian, Hagopian, William, Toppari, Jorma, Ziegler, Annette-Gabriele, Akolkar, Beena, Krischer, Jeffrey P, Petrosino, Joseph F, Lloyd, Richard E, Agardh, Daniel

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A combined risk score enhances prediction of type 1 diabetes among susceptible children von Ferrat, Lauric A., Vehik, Kendra, Sharp, Seth A., Lernmark, Åke, Rewers, Marian J., She, Jin-Xiong, Ziegler, Anette-G., Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P., Weedon, Michael N., Oram, Richard A., Hagopian, William A.

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Biallelic loss-of-function in NRAP is a cause of recessive dilated cardiomyopathy von Koskenvuo, Juha W., Saarinen, Inka, Ahonen, Saija, Tommiska, Johanna, Weckstrom, Sini, Seppala, Eija H., Tuupanen, Sari, Kangas-Kontio, Tiia, Schleit, Jennifer, Helio, Krista, Hathaway, Julie, Gummesson, Anders, Dahlberg, Pia, Ojala, Tiina H., Vepsalainen, Ville, Kytola, Ville, Muona, Mikko, Sistonen, Johanna, Salmenpera, Pertteli, Gentile, Massimiliano, Paananen, Jussi, Myllykangas, Samuel, Alastalo, Tero-Pekka, Helio, Tiina

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Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients von Hathaway, Julie, Helio, Krista, Saarinen, Inka, Tallila, Jonna, Seppala, Eija H., Tuupanen, Sari, Turpeinen, Hannu, Kangas-Kontio, Tiia, Schleit, Jennifer, Tommiska, Johanna, Kytola, Ville, Valori, Miko, Muona, Mikko, Sistonen, Johanna, Gentile, Massimiliano, Salmenpera, Pertteli, Myllykangas, Samuel, Paananen, Jussi, Alastalo, Tero-Pekka, Helio, Tiina, Koskenvuo, Juha

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Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report von Krischer, Jeffrey P, Liu, Xiang, Vehik, Kendra, Akolkar, Beena, Hagopian, William A, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette-G, Lernmark, Åke

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Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study von Vehik, Kendra, Bonifacio, Ezio, Lernmark, Ake, Yu, Liping, Williams, Alistair, Schatz, Desmond, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Hagopian, William, Akolkar, Beena, Ziegler, Anette G., Krischer, Jeffrey P.

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Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study von Krischer, Jeffrey P, Liu, Xiang, Lernmark, Åke, Hagopian, William A, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette-G, Akolkar, Beena

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An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood von Bonifacio, Ezio, Weiss, Andreas, Winkler, Christiane, Hippich, Markus, Rewers, Marian J., Toppari, Jorma, Lernmark, Ake, She, Jin-Xiong, Hagopian, William A., Krischer, Jeffrey P., Vehik, Kendra, Schatz, Desmond A., Akolkar, Beena, Ziegler, Anette-Gabriele

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SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens von Krischer, Jeffrey P., Lernmark, Åke, Hagopian, William A., Rewers, Marian J., McIndoe, Richard, Toppari, Jorma, Ziegler, Anette-Gabriele, Akolkar, Beena

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Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study von Liu, Xiang, Vehik, Kendra, Huang, Yangxin, Elding Larsson, Helena, Toppari, Jorma, Ziegler, Anette G., She, Jin-Xiong, Rewers, Marian, Hagopian, William A., Akolkar, Beena, Krischer, Jeffrey P.

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