Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mou... von Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition von Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State von Daemen, Anneleen, Liu, Bonnie, Song, Kyung, Kwong, Mandy, Gao, Min, Hong, Rebecca, Nannini, Michelle, Peterson, David, Liederer, Bianca M., de la Cruz, Cecile, Sangaraju, Dewakar, Jaochico, Allan, Zhao, Xiaofeng, Sandoval, Wendy, Hunsaker, Thomas, Firestein, Ron, Latham, Sheerin, Sampath, Deepak, Evangelista, Marie, Hatzivassiliou, Georgia

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An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium von Wright, Kevin J, Baye, Lisa M, Olivier-Mason, Anique, Mukhopadhyay, Saikat, Sang, Liyun, Kwong, Mandy, Wang, Weiru, Pretorius, Pamela R, Sheffield, Val C, Sengupta, Piali, Slusarski, Diane C, Jackson, Peter K

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Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress von Leung, Laura, Kwong, Mandy, Hou, Stephen, Lee, Candy, Chan, Jefferson Y

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Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable von Xiao, Yang, Kwong, Mandy, Daemen, Anneleen, Belvin, Marcia, Liang, Xiaorong, Hatzivassiliou, Georgia, O'Brien, Thomas

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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins von Laing, Steven T., Tassew, Nardos, Tesar, Devin, Wang, Yue, Crowell, Susan R., Gray, Julia, Kwong, Mandy, Loyet, Kelly M., Andaya, Roxanne, Kusi, Aija, Kelley, Robert F.

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Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618 von Xiao, Yang, Elkins, Kristi, Durieux, Jenni K, Lee, Leslie, Oeh, Jason, Yang, Lulu X, Liang, Xiaorong, DelNagro, Chris, Tremayne, Jarrod, Kwong, Mandy, Liederer, Bianca M, Jackson, Peter K, Belmont, Lisa D, Sampath, Deepak, O'Brien, Thomas

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule von Hosseini, Iraj, Fleisher, Brett, Getz, Jennifer, Decalf, Jérémie, Kwong, Mandy, Ovacik, Meric, Bainbridge, Travis W, Moussion, Christine, Rao, Gautham K, Gadkar, Kapil, Kamath, Amrita V, Ramanujan, Saroja

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Structural basis for resistance to diverse classes of NAMPT inhibitors von Wang, Weiru, Elkins, Kristi, Oh, Angela, Ho, Yen-Ching, Wu, Jiansheng, Li, Hong, Xiao, Yang, Kwong, Mandy, Coons, Mary, Brillantes, Bobby, Cheng, Eric, Crocker, Lisa, Dragovich, Peter S, Sampath, Deepak, Zheng, Xiaozhang, Bair, Kenneth W, O'Brien, Thomas, Belmont, Lisa D

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APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA von Schmidt, Kerstin N, Leung, Beatrice, Kwong, Mandy, Zarember, Kol A, Satyal, Sanjeev, Navas, Tony A, Wang, Fay, Godowski, Paul J

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Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays von Kwong, Mandy Mun Yee, Lee, Jee Whu, Samian, Mohammed Razip, Watanabe, Nobumoto, Osada, Hiroyuki, Ong, Eugene Boon Beng

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Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development von Chen, Linyun, Kwong, Mandy, Lu, Ronghua, Ginzinger, David, Lee, Candy, Leung, Laura, Chan, Jefferson Y.

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Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods von Pisabarro, M. Teresa, Leung, Beatrice, Kwong, Mandy, Corpuz, Racquel, Frantz, Gretchen D, Chiang, Nancy, Vandlen, Richard, Diehl, Lauri J, Skelton, Nicholas, Kim, Hok Seon, Eaton, Dan, Schmidt, Kerstin N

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Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma von Chen, Ruihuan, Nishimura, Merry C, Kharbanda, Samir, Peale, Frank, Deng, Yuzhong, Daemen, Anneleen, Forrest, William F, Kwong, Mandy, Hedehus, Maj, Hatzivassiliou, Georgia, Friedman, Lori S, Phillips, Heidi S

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Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span von Kwong, Mandy Mun Yee, Lee, Jee Whu, Samian, Mohammed Razip, Wahab, Habibah A., Watanabe, Nobumoto, Ong, Eugene Boon Beng

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the A beta 42:A beta 40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzhe... von Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A., Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David

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Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells von Gampa, Gautham, Spinosa, Phillip, Getz, Jennifer, Zhong, Yu, Halpern, Wendy, Esen, Emel, Davies, John, Chou, Cassie, Kwong, Mandy, Wang, Yingyun, Arenzana, Teresita L., Shivva, Vittal, Huseni, Mahrukh, Hsieh, Robert, Schartner, Jill, Koerber, James T., Rutz, Sascha, Hosseini, Iraj

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A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK von Li, Ran, Dere, Edward, Kwong, Mandy, Fei, Mingjian, Dave, Rutwij, Masih, Shabkhaiz, Wang, Joy, McNamara, Erin, Huang, Haochu, Liang, Wei-Ching, Schutt, Leah, Kamath, Amrita V., Ovacik, Meric A.

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Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice von Chan, Jefferson Y., Kwong, Mandy, Lo, Margaret, Emerson, Renee, Kuypers, Frans A.

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