Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing von Yin, Hao, Song, Chun-Qing, Suresh, Sneha, Wu, Qiongqiong, Walsh, Stephen, Rhym, Luke Hyunsik, Mintzer, Esther, Bolukbasi, Mehmet Fatih, Zhu, Lihua Julie, Kauffman, Kevin, Mou, Haiwei, Oberholzer, Alicia, Ding, Junmei, Kwan, Suet-Yan, Bogorad, Roman L, Zatsepin, Timofei, Koteliansky, Victor, Wolfe, Scot A, Xue, Wen, Langer, Robert, Anderson, Daniel G

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Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Down‐Regulating Mitotic Genes von Kwan, Suet‐Yan, Sheel, Ankur, Song, Chun‐Qing, Zhang, Xiao‐Ou, Jiang, Tingting, Dang, Hien, Cao, Yueying, Ozata, Deniz M., Mou, Haiwei, Yin, Hao, Weng, Zhiping, Wang, Xin Wei, Xue, Wen

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YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte‐Like Cells von Smith, Jordan L., Rodríguez, Tomás C., Mou, Haiwei, Kwan, Suet‐Yan, Pratt, Henry, Zhang, Xiao‐Ou, Cao, Yueying, Liang, Shunqing, Ozata, Deniz M., Yu, Tianxiong, Yin, Qiangzong, Hazeltine, Max, Weng, Zhiping, Sontheimer, Erik J., Xue, Wen

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Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes von Rodríguez, Tomás C, Kwan, Suet-Yan, Smith, Jordan L, Dadafarin, Sina, Wu, Chern-Horng, Sontheimer, Erik J, Xue, Wen

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KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low-grade serous carcinoma von Tsang, Yvonne T, Deavers, Michael T, Sun, Charlotte C, Kwan, Suet-Yan, Kuo, Eric, Malpica, Anais, Mok, Samuel C, Gershenson, David M, Wong, Kwong-Kwok

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Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells von Kwan, Suet-Yan, Cheng, Xuanjin, Tsang, Yvonne T M, Choi, Jong-Sun, Kwan, Suet-Ying, Izaguirre, Daisy I, Kwan, Hoi-Shan, Gershenson, David M, Wong, Kwong-Kwok

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A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver von Zheng, Chunwei, Liang, Shun-Qing, Liu, Bin, Liu, Pengpeng, Kwan, Suet-Yan, Wolfe, Scot A., Xue, Wen

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Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas von Crane, Erin K, Kwan, Suet-Yan, Izaguirre, Daisy I, Tsang, Yvonne T M, Mullany, Lisa K, Zu, Zhifei, Richards, JoAnne S, Gershenson, David M, Wong, Kwong-Kwok

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The Role of GDF15 in Regulating the Canonical Pathways of the Tumor Microenvironment in Wild-Type p53 Ovarian Tumor and Its Response to Chemotherapy von Izaguirre, Daisy I, Ng, Chun-Wai, Kwan, Suet-Yan, Kun, Eucharist H, Tsang, Yvonne T M, Gershenson, David M, Wong, Kwong-Kwok

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling von Mou, Haiwei, Ozata, Deniz M, Smith, Jordan L, Sheel, Ankur, Kwan, Suet-Yan, Hough, Soren, Kucukural, Alper, Kennedy, Zachary, Cao, Yueying, Xue, Wen

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity von Yin, Hao, Song, Chun-Qing, Suresh, Sneha, Kwan, Suet-Yan, Wu, Qiongqiong, Walsh, Stephen, Ding, Junmei, Bogorad, Roman L, Zhu, Lihua Julie, Wolfe, Scot A, Koteliansky, Victor, Xue, Wen, Langer, Robert, Anderson, Daniel G

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PAX2 Expression in Ovarian Cancer von Song, Huijuan, Kwan, Suet-Yan, Izaguirre, Daisy I, Zu, Zhifei, Tsang, Yvonne T, Tung, Celestine S, King, Erin R, Mok, Samuel C, Gershenson, David M, Wong, Kwong-Kwok

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Poor survival with wild-type TP53 ovarian cancer? von Wong, Kwong-Kwok, Izaguirre, Daisy I, Kwan, Suet-Yan, King, Erin R, Deavers, Michael T, Sood, Anil K, Mok, Samuel C, Gershenson, David M

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Abstract 3680: Loss of ARID1A expression leads to sensitivity to ROS-inducing agents in ovarian cancer cells von Kwan, Suet-Yan, Wong, Kwong-Kwok

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Abstract NTOC-114: ARID1A DEFICIENCY IN OVARIAN CLEAR CELL CARCINOMAS UP–REGULATES OXIDATIVE STRESS AND SENSITIZES CELLS TO ROS–INDUCING AGENTS von Kwan, Suet-Yan, Cheng, Xuanjin, Kwan, Suet-Ying, Izaguirre, Daisy I., Tsang, Yvonne T.M., Choi, Jong-Sun, Kwan, Hoi-Shan, Gershenson, David M., Wong, Kwong-Kwok

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes von Kwan, Suet-Yan, Sheel, Ankur, Song, Chun-Qing, Zhang, Xiao-Ou, Jiang, Tingting, Dang, Hien, Cao, Yueying, Ozata, Deniz M., Mou, Haiwei, Yin, Hao, Weng, Zhiping, Wang, Xin Wei, Xue, Wen

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Abstract 1529: Ovarian low grade serous cancer: Mutation analysis with a comprehensive 409 cancer gene panel von Tsang, Yvonne T., Izaguirre, Daisy, Kwan, Suet-Yan, Mok, Samuel C., Gershenson, David, Wong, Kwong-Kwok

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Abstract 4697: The PI3K/mTOR pathway is a potential therapeutic target in cancers with ARID1A mutations von Kwan, Suet-Yan, Izaguirre, Daisy I., Cheng, Xuanjin, Kwan, Suet-Ying, Tsang, Yvonne TM, Kwan, Hoi-Shan, Wong, Kwong-Kwok

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Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex von Wu, J, Lee, S-W, Zhang, X, Han, F, Kwan, S-Y, Yuan, X, Yang, W-L, Jeong, Y S, Rezaeian, A H, Gao, Y, Zeng, Y-X, Lin, H-K

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Abstract 3474: GDF15 as a serum marker of cisplatin response in ovarian cancer cells von Izaguirre, Daisy I., Kwan, Suet Yan, Zu, Zhifei, Tsang-Lee, Yvonne T., Wong, Kwong-Kwok

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