Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein von Petros, Andrew M., Swann, Steven L., Song, Danying, Swinger, Kerren, Park, Chang, Zhang, Haichao, Wendt, Michael D., Kunzer, Aaron R., Souers, Andrew J., Sun, Chaohong

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours von Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

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Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening von Kumar, Anuradha, Chettiar, Somsundaram, Brown, Brian S., Early, Julie, Ollinger, Juliane, Files, Megan, Bailey, Mai A., Korkegian, Aaron, Dennison, Devon, McNeil, Matthew, Metz, James, Osuma, Augustine, Curtin, Michael, Kunzer, Aaron, Freiberg, Gail, Bruncko, Milan, Kempf, Dale, Parish, Tanya

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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467 von Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew

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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins von Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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Rapid, robust, clean, catalyst-free synthesis of 2-halo-3-carboxyindoles von Kunzer, Aaron R., Wendt, Michael D.

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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients von Yuda, Junichiro, Will, Christine, Phillips, Darren C., Abraham, Linu, Alvey, Cory, Avigdor, Abraham, Buck, Wayne, Besenhofer, Lauren, Boghaert, Erwin, Cheng, Dong, Cojocari, Dan, Doyle, Kelly, Hansen, T. Matthew, Huang, Kevin, Johnson, Eric F., Judd, Andrew S., Judge, Russell A., Kalvass, John C., Kunzer, Aaron, Lam, Lloyd T., Li, Rachel, Martin, Ruth L., Mastracchio, Anthony, Mitten, Mike, Petrich, Adam, Wang, Jin, Ward, James E., Zhang, Haichao, Wang, Xilu, Wolff, Johannes E., Bell-McGuinn, Katherine M., Souers, Andrew J.

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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor von Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James

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Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies von Huth, Jeffrey R., Park, Chang, Petros, Andrew M., Kunzer, Aaron R., Wendt, Michael D., Wang, Xilu, Lynch, Christopher L., Mack, Jamey C., Swift, Kerry M., Judge, Russell A., Chen, Jun, Richardson, Paul L., Jin, Sha, Tahir, Stephen K., Matayoshi, Edward D., Dorwin, Sarah A., Ladror, Uri S., Severin, Jean M., Walter, Karl A., Bartley, Diane M., Fesik, Stephen W., Elmore, Steven W., Hajduk, Philip J.

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Discovery of a novel small molecule binding site of human survivin von Wendt, Michael D., Sun, Chaohong, Kunzer, Aaron, Sauer, Daryl, Sarris, Kathy, Hoff, Ethan, Yu, Liping, Nettesheim, David G., Chen, Jun, Jin, Sha, Comess, Kenneth M., Fan, Yihong, Anderson, Steven N., Isaac, Binumol, Olejniczak, Edward T., Hajduk, Philip J., Rosenberg, Saul H., Elmore, Steven W.

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A Facile One-Carbon Homologation of Aryl Aldehydes to Amides von Shen, Wang, Kunzer, Aaron

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X-L Inhibitor von Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James

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Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine von Wendt, Michael D., Kunzer, Aaron R.

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Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles von Wendt, Michael D., Kunzer, Aaron R.

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Ortho selectivity in S NAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine von Wendt, Michael D., Kunzer, Aaron R.

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BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors von Judd, Andrew S, Bawa, Bhupinder, Buck, Wayne R, Tao, Zhi-Fu, Li, Yingchun, Mitten, Michael J, Bruncko, Milan, Catron, Nathaniel, Doherty, George, Durbin, Kenneth R, Enright, Brian, Frey, Robin, Haasch, Deanna, Haman, Sandra, Haight, Anthony R, Henriques, Tracy A, Holms, James, Izeradjene, Kamel, Judge, Russell A, Jenkins, Gary J, Kunzer, Aaron, Leverson, Joel D, Martin, Ruth L, Mitra, Diya, Mittelstadt, Scott, Nelson, Lorne, Nimmer, Paul, Palma, Joann, Peterson, Richard, Phillips, Darren C, Ralston, Sherry L, Rosenberg, Saul H, Shen, Xiaoqiang, Song, Xiaohong, Vaidya, Kedar R, Wang, Xilu, Wang, Jin, Xiao, Yu, Zhang, Haichao, Zhang, Xinxin, Blomme, Eric A, Boghaert, Erwin R, Kalvass, John C, Phillips, Andrew, Souers, Andrew J

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BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors von Judd, Andrew S, Bawa, Bhupinder, Buck, Wayne R, Tao, Zhi-Fu, Li, Yingchun, Mitten, Michael J, Bruncko, Milan, Catron, Nathaniel, Doherty, George, Durbin, Kenneth R, Enright, Brian, Frey, Robin, Haasch, Deanna, Haman, Sandra, Haight, Anthony R, Henriques, Tracy A, Holms, James, Izeradjene, Kamel, Judge, Russell A, Jenkins, Gary J, Kunzer, Aaron, Leverson, Joel D, Martin, Ruth L, Mitra, Diya, Mittelstadt, Scott, Nelson, Lorne, Nimmer, Paul, Palma, Joann, Peterson, Richard, Phillips, Darren C, Ralston, Sherry L, Rosenberg, Saul H, Shen, Xiaoqiang, Song, Xiaohong, Vaidya, Kedar R, Wang, Xilu, Wang, Jin, Xiao, Yu, Zhang, Haichao, Zhang, Xinxin, Blomme, Eric A, Boghaert, Erwin R, Kalvass, John C, Phillips, Andrew, Souers, Andrew J

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo von Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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Regiochemistry of addition of aminoheterocycles to α-cyanocinnamonitriles: formation of aza-bridged bi- and tricycles von Wendt, Michael D., Kunzer, Aaron, Henry, Rodger F., Cross, Jeffrey, Pagano, Thomas G.

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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL von Bruncko, Milan, Oost, Thorsten K, Belli, Barbara A, Ding, Hong, Joseph, Mary K, Kunzer, Aaron, Martineau, Darlene, McClellan, William J, Mitten, Michael, Ng, Shi-Chung, Nimmer, Paul M, Oltersdorf, Tilman, Park, Cheol-Min, Petros, Andrew M, Shoemaker, Alexander R, Song, Xiaohong, Wang, Xilu, Wendt, Michael D, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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