Incorporating lesion-to-lesion heterogeneity into early oncology decision making von Kumar, Rukmini, Qi, Timothy, Cao, Yanguang, Topp, Brian

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Applying quantitative and systems pharmacology to drug development and beyond: An introduction to clinical pharmacologists von Ramasubbu, Mathan Kumar, Paleja, Bhairav, Srinivasann, Anand, Maiti, Rituparna, Kumar, Rukmini

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Quantitative systems pharmacology model of erythropoiesis to simulate therapies targeting anemia due to chronic kidney disease von Roy, Mrittika, Saroha, Shaifali, Sarma, Uddipan, Sarathy, Harini, Kumar, Rukmini

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Multiscale, mechanistic model of Rheumatoid Arthritis to enable decision making in late stage drug development von Bedathuru, Dinesh, Rengaswamy, Maithreye, Channavazzala, Madhav, Ray, Tamara, Packrisamy, Prakash, Kumar, Rukmini

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Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response von Kumar, Rukmini, Thiagarajan, Kannan, Jagannathan, Lakshmanan, Liu, Liming, Mayawala, Kapil, Alwis, Dinesh, Topp, Brian

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Can a propensity score matching method be applied to assessing efficacy from single-arm proof-of-concept trials in oncology? von Teng, Shu-Wen, Su, Yu-Cheng, Pallantla, Ravikumar, Channavazzala, Madhav, Kumar, Rukmini, Sheng, Yucheng, Wang, Hao, Wang, Crystal, Tse, Archie

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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI von Howell, Brett A., Yang, Yuching, Kumar, Rukmini, Woodhead, Jeffrey L., Harrill, Alison H., Clewell, Harvey J., Andersen, Melvin E., Siler, Scott Q., Watkins, Paul B.

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Abstract PO-131: Inter-tumoral heterogeneity of progressive disease in melanoma patients treated with pembrolizumab von Topp, Brian, Kumar, Rukmini, Mayawala, Kapil, de Alwis, Dinesh, Hellmann, Matt D., Snyder, Alexandra

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An integrated quantitative systems pharmacology virtual population approach for calibration with oncology efficacy endpoints von Braniff, Nathan, Joshi, Tanvi, Cassidy, Tyler, Trogdon, Michael, Kumar, Rukmini, Poels, Kamrine, Allen, Richard, Musante, Cynthia J., Shtylla, Blerta

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The dynamics of acute inflammation von Kumar, Rukmini, Clermont, Gilles, Vodovotz, Yoram, Chow, Carson C.

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In silico design of clinical trials: A method coming of age von Clermont, Gilles, Bartels, John, Kumar, Rukmini, Constantine, Greg, Vodovotz, Yoram, Chow, Carson

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A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION von Kumar, Rukmini, Chow, Carson C., Bartels, John D., Clermont, Gilles, Vodovotz, Yoram

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The acute inflammatory response in diverse shock states von CHOW, Carson C, CLERMONT, Gilles, BILLIAR, Timothy R, VODOVOTZ, Yoram, KUMAR, Rukmini, LAGOA, Claudio, TAWADROUS, Zacharia, GALLO, David, BETTEN, Binnie, BARTELS, John, CONSTANTINE, Gregory, FINK, Mitchell P

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A mathematical simulation of the inflammatory response to anthrax infection von Kumar, Rukmini, Chow, Carson C, Bartels, John D, Clermont, Gilles, Vodovotz, Yoram

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Evaluating the efficacy of combination of checkpoint inhibitors and chemotherapy in Lung Cancer using mechanistic model von Thiagarajan, Kannan, Mohan, Aparna, Sareen, Amay, Channavazzala, Madhav, Ray, Tamara, Roy, Mrittika, Kumar, Rukmini

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Mechanistic modeling informed optimization of LNPs for mRNA drug delivery, efficacy, and dose prediction von BC, Narmada, Dutta, Raunak, Paleja, Bhairav, Channavazzala, Madhav, Kumar, Rukmini

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QSP model of Rheumatoid Arthritis, capturing range of responses toMethotrexate, Adalimumab and Tocilizumab therapies von Dinesh, Bedathuru, Aijaz, Shaliban, Tamara, Ray, Maithreye, Rengaswamy, Prakash, Packrisamy, Madhav, Channavazzala, Rukmini, Kumar

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Extending a QSP model of CD3 Bispecific Antibody Therapies to support First In Human Dosing (FIH) for Acute Myeloid Leukemia Treatment von PC, Seshasai, Nair, Goutam, Pallantla, Ravikumar, Mitra, Debarshi, Yadav, Saumya, Paleja, Bhairav, Bedathuru, Dinesh, Kumar, Rukmini

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In silico models of acute inflammation in animals von VODOVOTZ, Yoram, CHOW, Carson C, BILLIAR, Timothy R, FINK, Mitchell P, CLERMONT, Gilles, BARTELS, John, LAGOA, Claudio, PRINCE, Jose M, LEVY, Ryan M, KUMAR, Rukmini, DAY, Judy, RUBIN, Jonathan, CONSTANTINE, Greg

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Prediction of the acute inflammatory response from a mathematical model von Lagoa, Claudio E, Clermont, Gilles, Kumar, Rukmini, Bartels, John

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