Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models von Pitts, Todd M, Kulikowski, Gillian N, Tan, Aik-Choon, Murray, Brion W, Arcaroli, John J, Tentler, John J, Spreafico, Anna, Selby, Heather M, Kachaeva, Maria I, McPhillips, Kelly L, Britt, Blair C, Bradshaw-Pierce, Erica L, Messersmith, Wells A, Varella-Garcia, Marileila, Eckhardt, S Gail

Volltext

Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models von FLANIGAN, Sara A, PITTS, Todd M, GAIL ECKHARDT, S, LEONG, Stephen, NEWTON, Timothy P, KULIKOWSKI, Gillian N, AIK CHOON TAN, MCMANUS, Martine C, SPREAFICO, Anna, KACHAEVA, Maria I, SELBY, Heather M, TENTLER, John J

Volltext

Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development von PITTS, Todd M, CHOON TAN, Aik, KORCH, Christopher, ECKHARDT, S. Gail, KULIKOWSKI, Gillian N, TENTLER, John J, BROWN, Amy M, FLANIGAN, Sara A, LEONG, Stephen, COLDREN, Christopher D, HIRSCH, Fred R, VARELLA-GARCIA, Marileila

Volltext

Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer von Tentler, John J, Nallapareddy, Sujatha, Tan, Aik Choon, Spreafico, Anna, Pitts, Todd M, Morelli, M Pia, Selby, Heather M, Kachaeva, Maria I, Flanigan, Sara A, Kulikowski, Gillian N, Leong, Stephen, Arcaroli, John J, Messersmith, Wells A, Eckhardt, S Gail

Volltext

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of ENMD-2076, a Novel Angiogenic and Aurora Kinase Inhibitor, in Patients with Advanced Solid Tumors von DIAMOND, Jennifer R, BASTOS, Bruno R, MORROW, Mark, ARNOTT, Jamie, BRAY, Mark R, SIDOR, Carolyn, MESSERSMITH, Wells, SHAPIRO, Geoffrey I, HANSEN, Ryan J, GUSTAFSON, Daniel L, GAIL ECKHARDT, S, KWAK, Eunice L, PANDYA, Shuchi S, FLETCHER, Graham C, PITTS, Todd M, KULIKOWSKI, Gillian N

Volltext

Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-Mutant Colorectal Cancer Models von PIA MORELLI, M, TENTLER, John J, HIDALGO, Manuel, CIARDIELLO, Fortunato, GAIL ECKHARDT, S, KULIKOWSKI, Gillian N, TAN, Aik-Choon, BRADSHAW-PIERCE, Erica L, PITTS, Todd M, BROWN, Amy M, NALLAPAREDDY, Sujatha, ARCAROLI, John J, SERKOVA, Natalie J

Volltext

Abstract A256: Rational combination of the IGF-1R/IR tyrosine kinase inhibitor (TKI), OSI-906, with the MEK inhibitor, U0126, results in synergistic and apoptotic effects in human... von Flanigan, Sara A., Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik Choon, Nallapareddy, Sujatha, Tentler, John J., Eckhardt, S. Gail, Leong, Stephen

Volltext

Abstract A39: Development and validation of an integrated genomic classifier to predict sensitivity to the IGF-1R/IR tyrosine kinase inhibitor, OSI-906, in colorectal cancer von Pitts, Todd M., Tan, Aik Choon, Kulikowski, Gillian N., Tentler, John J., Flanigan, Sara A., Leong, Stephen, Brown, Amy, Coldren, Chris D., Varella-Garcia, Marileila, Hirsch, Fred R., Eckhardt, S. Gail

Volltext

Abstract B169: Characterization of in vitro activity and predictive biomarkers of the novel p21-activated kinase 4 (PAK4) inhibitor, PF-3758309, in colorectal cancer cell lines von Kulikowski, Gillian N., Pitts, Todd M., Tan, Aik Choon, Tentler, John J., Britt, Blair C., Britt, Byron W., Murray, Brion W., Carley, William, Smeal, Tod, Guo, Chuangxing, Eckhardt, S. Gail

Volltext