Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis von Root, Jessica, Merino, Paola, Nuckols, Austin, Johnson, Michelle, Kukar, Thomas

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Progranulin deficiency leads to reduced glucocerebrosidase activity von Zhou, Xiaolai, Paushter, Daniel H, Pagan, Mitchell D, Kim, Dongsung, Nunez Santos, Mariela, Lieberman, Raquel L, Overkleeft, Herman S, Sun, Ying, Smolka, Marcus B, Hu, Fenghua

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TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD von Chou, Ching-Chieh, Zhang, Yi, Umoh, Mfon E., Vaughan, Spencer W., Lorenzini, Ileana, Liu, Feilin, Sayegh, Melissa, Donlin-Asp, Paul G., Chen, Yu Han, Duong, Duc M., Seyfried, Nicholas T., Powers, Maureen A., Kukar, Thomas, Hales, Chadwick M., Gearing, Marla, Cairns, Nigel J., Boylan, Kevin B., Dickson, Dennis W., Rademakers, Rosa, Zhang, Yong-Jie, Petrucelli, Leonard, Sattler, Rita, Zarnescu, Daniela C., Glass, Jonathan D., Rossoll, Wilfried

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Short Aβ peptides attenuate Aβ42 toxicity in vivo von Moore, Brenda D, Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E, Ceballos-Diaz, Carolina, Ladd, Thomas B, Ran, Yong, Levites, Yona, Kukar, Thomas L, Kurian, Justin J, McKenna, Robert, Koo, Edward H, Borchelt, David R, Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E

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Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36 von McEachin, Zachary T., Gendron, Tania F., Raj, Nisha, García-Murias, María, Banerjee, Anwesha, Purcell, Ryan H., Ward, Patricia J., Todd, Tiffany W., Merritt-Garza, Megan E., Jansen-West, Karen, Hales, Chadwick M., García-Sobrino, Tania, Quintáns, Beatriz, Holler, Christopher J., Taylor, Georgia, San Millán, Beatriz, Teijeira, Susana, Yamashita, Toru, Ohkubo, Ryuichi, Boulis, Nicholas M., Xu, Chongchong, Wen, Zhexing, Streichenberger, Nathalie, Fogel, Brent L., Kukar, Thomas, Abe, Koji, Dickson, Dennis W., Arias, Manuel, Glass, Jonathan D., Jiang, Jie, Tansey, Malú G., Sobrido, María-Jesús, Petrucelli, Leonard, Rossoll, Wilfried, Bassell, Gary J.

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Substrate-targeting γ-secretase modulators von Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.

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Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity von Ghag, Gaurav, Holler, Christopher J., Taylor, Georgia, Kukar, Thomas L., Uversky, Vladimir N., Rangachari, Vijayaraghavan

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Molecular Signatures of Neuroinflammation Induced by alpha Synuclein Aggregates in Microglial Cells von Sarkar, Souvarish, Dammer, Eric B., Malovic, Emir, Olsen, Abby L., Raza, Syed Ali, Gao, Tianwen, Xiao, Hailian, Oliver, Danielle L., Duong, Duc, Joers, Valerie, Seyfried, Nicholas, Huang, Meixiang, Kukar, Thomas, Tansey, Malu G., Kanthasamy, Anumantha G., Rangaraju, Srikant

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Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia von Holler, Christopher J, Taylor, Georgia, McEachin, Zachary T, Deng, Qiudong, Watkins, William J, Hudson, Kathryn, Easley, Charles A, Hu, William T, Hales, Chadwick M, Rossoll, Wilfried, Bassell, Gary J, Kukar, Thomas

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Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations von Huang, Meixiang, Modeste, Erica, Dammer, Eric, Merino, Paola, Taylor, Georgia, Duong, Duc M, Deng, Qiudong, Holler, Christopher J, Gearing, Marla, Dickson, Dennis, Seyfried, Nicholas T, Kukar, Thomas

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Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage von Johnson, Michelle A., Deng, Qiudong, Taylor, Georgia, McEachin, Zachary T., Chan, Anthony W.S., Root, Jessica, Bassell, Gary J., Kukar, Thomas

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and... von Kukar, Thomas L, Ladd, Thomas B, Robertson, Paul, Pintchovski, Sean A, Moore, Brenda, Bann, Maralyssa A, Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A, Das, Pritam, Basi, Guriqbal S, Koo, Edward H, Golde, Todd E

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production von Golde, Todd E, Kukar, Thomas, Murphy, Michael Paul, Eriksen, Jason L, Sagi, Sarah A, Weggen, Sascha, Smith, Tawnya E, Ladd, Thomas, Khan, Murad A, Kache, Rajashaker, Beard, Jenny, Dodson, Mark, Merit, Sami, Ozols, Victor V, Anastasiadis, Panos Z, Das, Pritam, Fauq, Abdul, Koo, Edward H

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Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ‑Secretase Processivity Induced by γ‑Secretase Modulators von Jung, Joo In, Ran, Yong, Cruz, Pedro E, Rosario, Awilda M, Ladd, Thomas B, Kukar, Thomas L, Koo, Edward H, Felsenstein, Kevin M, Golde, Todd E

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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis von Verbeeck, Christophe, Deng, Qiudong, Dejesus-Hernandez, Mariely, Taylor, Georgia, Ceballos-Diaz, Carolina, Kocerha, Jannet, Golde, Todd, Das, Pritam, Rademakers, Rosa, Dickson, Dennis W, Kukar, Thomas

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Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice von Kukar, Thomas, Prescott, Sonya, Eriksen, Jason L, Holloway, Vallie, Murphy, M Paul, Koo, Edward H, Golde, Todd E, Nicolle, Michelle M

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Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein von Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.

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Avoiding Unintended Toxicity von Golde, Todd E, Kukar, Thomas L

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Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase von Nyborg, Andrew C, Ladd, Thomas B, Jansen, Karen, Kukar, Thomas, Golde, Todd E

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Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology von Das, Pritam, Verbeeck, Christophe, Minter, Lisa, Chakrabarty, Paramita, Felsenstein, Kevin, Kukar, Thomas, Maharvi, Ghulam, Fauq, Abdul, Osborne, Barbara A, Golde, Todd E

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