Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death von Gaipl, U S, Kuenkele, S, Voll, R E, Beyer, T D, Kolowos, W, Heyder, P, Kalden, J R, Herrmann, M

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Cooperation between C1q and DNase I in the clearance of necrotic cell–derived chromatin von Gaipl, Udo S., Beyer, Thomas D., Heyder, Petra, Kuenkele, Susanne, Böttcher, Andrea, Voll, Reinhard E., Kalden, Joachim R., Herrmann, Martin

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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions von Schmelz, Karin, Toedling, Joern, Huska, Matt, Cwikla, Maja C., Kruetzfeldt, Louisa-Marie, Proba, Jutta, Ambros, Peter F., Ambros, Inge M., Boral, Sengül, Lodrini, Marco, Chen, Celine Y., Burkert, Martin, Guergen, Dennis, Szymansky, Annabell, Astrahantseff, Kathy, Kuenkele, Annette, Haase, Kerstin, Fischer, Matthias, Deubzer, Hedwig E., Hertwig, Falk, Hundsdoerfer, Patrick, Henssen, Anton G., Schwarz, Roland F., Schulte, Johannes H., Eggert, Angelika

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R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Al... von PAPPO, Alberto S, PATEL, Shreyaskumar R, GANJOO, Kristen N, SCHUETZE, Scott M, JUERGENS, Heribert, LEAHY, Michael G, GEOERGER, Birgit, BENJAMIN, Robert S, HELMAN, Lee J, BAKER, Laurence H, CROWLEY, John, REINKE, Denise K, KUENKELE, Klaus-Peter, CHAWLA, Sant P, TONER, Guy C, MAKI, Robert G, MEYERS, Paul A, CHUGH, Rashmi

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The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology von Wienke, Judith, Dierselhuis, Miranda P., Tytgat, Godelieve A.M., Künkele, Annette, Nierkens, Stefan, Molenaar, Jan J.

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Joining Forces for Cancer Treatment: From "TCR versus CAR" to "TCR and CAR" von Teppert, Karin, Wang, Xueting, Anders, Kathleen, Evaristo, César, Lock, Dominik, Künkele, Annette

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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma von Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

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Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells von Reincke, S Momsen, von Wardenburg, Niels, Homeyer, Marie A, Kornau, Hans-Christian, Spagni, Gregorio, Li, Lucie Y, Kreye, Jakob, Sánchez-Sendín, Elisa, Blumenau, Sonja, Stappert, Dominik, Radbruch, Helena, Hauser, Anja E, Künkele, Annette, Edes, Inan, Schmitz, Dietmar, Prüss, Harald

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Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges von Zappa, Elisa, Vitali, Alice, Anders, Kathleen, Molenaar, Jan J., Wienke, Judith, Künkele, Annette

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R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis von Huang, Helen J, Angelo, Laura S, Rodon, Jordi, Sun, Michael, Kuenkele, Klaus-Peter, Parsons, Henrique A, Trent, Jonathan C, Kurzrock, Razelle

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MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells von Schulte, J H, Lindner, S, Bohrer, A, Maurer, J, De Preter, K, Lefever, S, Heukamp, L, Schulte, S, Molenaar, J, Versteeg, R, Thor, T, Künkele, A, Vandesompele, J, Speleman, F, Schorle, H, Eggert, A, Schramm, A

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Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility von Künkele, Annette, Taraseviciute, Agne, Finn, Laura S, Johnson, Adam J, Berger, Carolina, Finney, Olivia, Chang, Cindy A, Rolczynski, Lisa S, Brown, Christopher, Mgebroff, Stephanie, Berger, Michael, Park, Julie R, Jensen, Michael C

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Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma von Lodrini, Marco, Graef, Josefine, Thole-Kliesch, Theresa M, Astrahantseff, Kathy, Sprüssel, Annika, Grimaldi, Maddalena, Peitz, Constantin, Linke, Rasmus B, Hollander, Jan F, Lankes, Erwin, Künkele, Annette, Oevermann, Lena, Schwabe, Georg, Fuchs, Jörg, Szymansky, Annabell, Schulte, Johannes H, Hundsdörfer, Patrick, Eckert, Cornelia, Amthauer, Holger, Eggert, Angelika, Deubzer, Hedwig E

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Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition von Croasdale, Rebecca, Wartha, Katharina, Schanzer, Juergen M., Kuenkele, Klaus-Peter, Ries, Carola, Mayer, Klaus, Gassner, Christian, Wagner, Martina, Dimoudis, Nikolaos, Herter, Sylvia, Jaeger, Christiane, Ferrara, Claudia, Hoffmann, Eike, Kling, Lothar, Lau, Wilma, Staack, Roland F., Heinrich, Julia, Scheuer, Werner, Stracke, Jan, Gerdes, Christian, Brinkmann, Ulrich, Umana, Pablo, Klein, Christian

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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing von Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C, Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H, Künkele, Annette

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The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity von Nguyen, Ngoc Thien Thu, Müller, Rasmus, Briukhovetska, Daria, Weber, Justus, Feucht, Judith, Künkele, Annette, Hudecek, Michael, Kobold, Sebastian

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Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist von García-Martínez, Juan Manuel, Wang, Shirley, Weishaeupl, Cordula, Wernitznig, Andreas, Chetta, Paolo, Pinto, Catarina, Ho, Jason, Dutcher, Darrin, Gorman, Philip N, Kroe-Barrett, Rachel, Rinnenthal, Joerg, Giragossian, Craig, Impagnatiello, Maria Antonietta, Tirapu, Iñigo, Hilberg, Frank, Kraut, Norbert, Pearson, Mark, Kuenkele, Klaus Peter

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Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model von Mueller-Schoell, Anna, Puebla-Osorio, Nahum, Michelet, Robin, Green, Michael R., Künkele, Annette, Huisinga, Wilhelm, Strati, Paolo, Chasen, Beth, Neelapu, Sattva S., Yee, Cassian, Kloft, Charlotte

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Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD von Künkele, Annette, Johnson, Adam J, Rolczynski, Lisa S, Chang, Cindy A, Hoglund, Virginia, Kelly-Spratt, Karen S, Jensen, Michael C

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Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells von Berlak, Mareike, Tucker, Elizabeth, Dorel, Mathurin, Winkler, Annika, McGearey, Aleixandria, Rodriguez-Fos, Elias, da Costa, Barbara Martins, Barker, Karen, Fyle, Elicia, Calton, Elizabeth, Eising, Selma, Ober, Kim, Hughes, Deborah, Koutroumanidou, Eleni, Carter, Paul, Stankunaite, Reda, Proszek, Paula, Jain, Neha, Rosswog, Carolina, Dorado-Garcia, Heathcliff, Molenaar, Jan Jasper, Hubank, Mike, Barone, Giuseppe, Anderson, John, Lang, Peter, Deubzer, Hedwig Elisabeth, Künkele, Annette, Fischer, Matthias, Eggert, Angelika, Kloft, Charlotte, Henssen, Anton George, Boettcher, Michael, Hertwig, Falk, Blüthgen, Nils, Chesler, Louis, Schulte, Johannes Hubertus

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