Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control von Quixabeira, Dafne C. A., Zafar, Sadia, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Kudling, Tatiana V., Basnet, Saru, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

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Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression von Kudling, Tatiana V., Clubb, James H.A., Quixabeira, Dafne C.A., Santos, Joao M., Havunen, Riikka, Kononov, Alexander, Heiniö, Camilla, Cervera-Carrascon, Victor, Pakola, Santeri, Basnet, Saru, Grönberg-Vähä-Koskela, Susanna, Arias, Victor, Gladwyn-Ng, Ivan, Aro, Katri, Bäck, Leif, Räsänen, Jari, Ilonen, Ilkka, Borenius, Kristian, Räsänen, Mikko, Hemminki, Otto, Rannikko, Antti, Kanerva, Anna, Tapper, Johanna, Hemminki, Akseli

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Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer von Clubb, James H A, Kudling, Tatiana V, Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C A, Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli

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Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 von Quixabeira, Dafne C. A., Cervera-Carrascon, Victor, Santos, Joao M., Clubb, James H.A., Kudling, Tatiana V., Basnet, Saru, Heiniö, Camilla, Grönberg-Vähä-Koskela, Susanna, Anttila, Marjukka, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli

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An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartmen... von Pakola, Santeri, Quixabeira, Dafne C A, Kudling, Tatiana V, Clubb, James H A, Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M, Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli

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Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer von Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli

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Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting von Clubb, James H A, Kudling, Tatiana V, Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C A, Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli

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Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors von Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

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Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site von Beyer, Hannes M., Mikula, Kornelia M., Kudling, Tatiana V., Iwaï, Hideo

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Epitope specificity of two anti‐morphine monoclonal antibodies: In vitro and in silico studies von Trofimov, Alexander V., Sokolov, Alexey V., Rak, Alexandra Y., Ischenko, Alexander M., Kudling, Tatiana V., Vakhrushev, Andrey V., Gorbunov, Alexei A.

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1518 T-cell inducing oncolytic virus (igrelimogene litadenorepvec; TILT-123) shows safety, anti-tumor activity and induction of immune responses in advanced solid tumor patients (f... von Santos, Joao, Peltola, Katriina, Alanko, Tuomo, Pakola, Santeri A, Clubb, James, Jirovec, Elise, Haybout, Lyna, Kudling, Tatiana V, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Quixabeira, Dafne CA, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Cervera-Carrascon, Victor, Hemminki, Akseli

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814 Enhancing anti-tumor response in ICI-refractory non-small cell lung cancer through intravenous administration of oncolytic adenovirus armed with hTNFα and hIL-2 in combination... von Kudling, Tatiana V, Clubb, James, Pakola, Santeri A, Quixabeira, Dafne Alves, Lähdeniemi, Iris, Heiniö, Camilla, Arias, Victor, Grönberg-Vähä-Koskela, Susanna AM, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao Manuel, Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko, Altonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W, Ilonen, Ilkka, Hemminki, Akseli

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