Diverse mutational landscapes in human lymphocytes von Machado, Heather E., Mitchell, Emily, Øbro, Nina F., Kübler, Kirsten, Davies, Megan, Leongamornlert, Daniel, Cull, Alyssa, Maura, Francesco, Sanders, Mathijs A., Cagan, Alex T. J., McDonald, Craig, Belmonte, Miriam, Shepherd, Mairi S., Vieira Braga, Felipe A., Osborne, Robert J., Mahbubani, Krishnaa, Martincorena, Iñigo, Laurenti, Elisa, Green, Anthony R., Getz, Gad, Polak, Paz, Saeb-Parsy, Kourosh, Hodson, Daniel J., Kent, David G., Campbell, Peter J.

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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues von Yizhak, Keren, Aguet, François, Kim, Jaegil, Hess, Julian M, Kübler, Kirsten, Grimsby, Jonna, Frazer, Ruslana, Zhang, Hailei, Haradhvala, Nicholas J, Rosebrock, Daniel, Livitz, Dimitri, Li, Xiao, Arich-Landkof, Eila, Shoresh, Noam, Stewart, Chip, Segrè, Ayellet V, Branton, Philip A, Polak, Paz, Ardlie, Kristin G, Getz, Gad

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer von Polak, Paz, Kim, Jaegil, Braunstein, Lior Z, Karlic, Rosa, Haradhavala, Nicholas J, Tiao, Grace, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W, Kamburov, Atanas, Maruvka, Yosef E, Leshchiner, Ignaty, Lander, Eric S, Golub, Todd R, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S, Batra, Rajbir N, Caldas, Carlos, Haber, Daniel A, Laird, Peter W, Shen, Hui, Ellisen, Leif W, D'Andrea, Alan D, Chanock, Stephen J, Foulkes, William D, Getz, Gad

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA von Herzner, Anna-Maria, Hagmann, Cristina Amparo, Goldeck, Marion, Wolter, Steven, Kübler, Kirsten, Wittmann, Sabine, Gramberg, Thomas, Andreeva, Liudmila, Hopfner, Karl-Peter, Mertens, Christina, Zillinger, Thomas, Jin, Tengchuan, Xiao, Tsan Sam, Bartok, Eva, Coch, Christoph, Ackermann, Damian, Hornung, Veit, Ludwig, Janos, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin

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Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma von Gopal, Raj K., Kübler, Kirsten, Calvo, Sarah E., Polak, Paz, Livitz, Dimitri, Rosebrock, Daniel, Sadow, Peter M., Campbell, Braidie, Donovan, Samuel E., Amin, Salma, Gigliotti, Benjamin J., Grabarek, Zenon, Hess, Julian M., Stewart, Chip, Braunstein, Lior Z., Arndt, Peter F., Mordecai, Scott, Shih, Angela R., Chaves, Frances, Zhan, Tiannan, Lubitz, Carrie C., Kim, Jiwoong, Iafrate, A. John, Wirth, Lori, Parangi, Sareh, Leshchiner, Ignaty, Daniels, Gilbert H., Mootha, Vamsi K., Dias-Santagata, Dora, Getz, Gad, McFadden, David G.

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N6-methyladenosine RNA modification (m6A) is of prognostic value in HPV-dependent vulvar squamous cell carcinoma von Condic, Mateja, Thiesler, Thore, Staerk, Christian, Klümper, Niklas, Ellinger, Jörg, Egger, Eva K, Kübler, Kirsten, Kristiansen, Glen, Mustea, Alexander, Ralser, Damian J

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Genetic alterations of HLA‐class II in ovarian cancer von Kübler, Kirsten, Arndt, Peter F., Wardelmann, Eva, Landwehr, Christina, Krebs, Dieter, Kuhn, Walther, van der Ven, Katrin

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Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma von Kübler, Kirsten, Ayub, Tiyasha H, Weber, Sarah K, Zivanovic, Oliver, Abramian, Alina, Keyver-Paik, Mignon-Denise, Mallmann, Michael R, Kaiser, Christina, Serçe, Nuran Bektas, Kuhn, Walther, Rudlowski, Christian

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Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells von Kübler, Kirsten, tho Pesch, Carola, Gehrke, Nadine, Riemann, Soheila, Daßler, Juliane, Coch, Christoph, Landsberg, Jennifer, Wimmenauer, Vera, Pölcher, Martin, Rudlowski, Christian, Tüting, Thomas, Kuhn, Walther, Hartmann, Gunther, Barchet, Winfried

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Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer von Ayub, Tiyasha H, Keyver-Paik, Mignon-Denise, Debald, Manuel, Rostamzadeh, Babak, Thiesler, Thore, Schröder, Lars, Barchet, Winfried, Abramian, Alina, Kaiser, Christina, Kristiansen, Glen, Kuhn, Walther, Kübler, Kirsten

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Abstract 3304: The mutation landscape of cancers serves as a record of early malignant transformation von Polak, Paz, Karlic, Rosa, Kubler, Kirsten, Foulkes, William D., Getz, Gad

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Targeted Activation of RNA Helicase Retinoic Acid-Inducible Gene-I Induces Proimmunogenic Apoptosis of Human Ovarian Cancer Cells von KÜBLER, Kirsten, GEHRKE, Nadine, BARCHET, Winfried, RIEMANN, Soheila, BÖHNERT, Volker, ZILLINGER, Thomas, HARTMANN, Evelyn, PÖLCHER, Martin, RUDLOWSKI, Christian, KUHN, Walther, HARTMANN, Gunther

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COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors von Yang, Sungmin, Ha, Kyungsik, Song, Woojeung, Fujita, Masashi, Kübler, Kirsten, Polak, Paz, Hiyama, Eiso, Nakagawa, Hidewaki, Kim, Hong-Gee, Lee, Hwajin

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Abstract GS2-09: Tamoxifen instigates uterine cancer development by activating PI3K signaling and supersedes PIK3CA driver mutations von Kubler, Kirsten, Nardone, Agostina, Anand, Shankara, Gorvich, Daniel, Droog, Marjolein, Hermida-Prado, Francisco, Akshi, Tara, Feit, Avery S, Cohen, Gabriella, Dackus, Gwen, Pun, Matthew, Kuang, Yanan, Cha, Justin, Miller, Mendy, Gibson, William J, Paweletz, Cloud P, Van Allen, Eliezer M, van Leeuwen, Flora E, Nederlof, Petra, Hollema, Harry, Nguyen, Quang-Dé, Mourits, Marian JE, Leshchiner, Ignaty, Stewart, Chip, Matulonis, Ursula A, Zwart, Wilbert, Maruvka, Yosef E, Getz, Gad, Jeselsohn, Rinath

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Cardiorenal syndrome is present in human fetuses with severe, isolated urinary tract malformations von Merz, Waltraut M, Kübler, Kirsten, Fimmers, Rolf, Willruth, Arne, Stoffel-Wagner, Birgit, Gembruch, Ulrich

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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues von Yizhak, Keren, Aguet, Francois, Kim, Jaegil, Hess, Julian, Kubler, Kirsten, Grimsby, Jonna, Frazer, Ruslana, Zhang, Hailei, Haradhvala, Nicholas, Rosebrock, Daniel, Livitz, Dimitri, Li, Xiao, Arich-Landkof, Eila, Shoresh, Noam, Stewart, Chip, Segre, Ayelet, Branton, Philip A, Polak, Paz, Ardlie, Kristin, Getz, Gad

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Abstract 2727: The premalignant state captured in the landscape of somatic mutations can reveal the cancer cell-of-origin von Kubler, Kirsten, Karlic, Rosa, Haradhvala, Nicholas J., Ha, Kyungsik, Kim, Jaegil, Kuzman, Maja, Jiao, Wei, Gakkhar, Sitanshu, Mouw, Kent W., Braunstein, Lior Z., Elemento, Olivier, Biankin, Andrew V., Rooman, Ilse, Miller, Mendy, Nogiec, Christopher D., Curry, Edward, Mino-Kenudson, Mari, Ellisen, Leif W., Brown, Robert, Gusev, Alexander, Tomasetti, Cristian, Kim, Hong-Gee, Lee, Hwajin, Vlahovicek, Kristian, Sawyers, Charles, Hoadley, Katherine A., Cuppen, Edwin, Koren, Amnon, Arndt, Peter F., Louis, David N., Stein, Lincoln, Foulkes, William D., Polak, Paz, Getz, Gad

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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns von Jiao, Wei, Atwal, Gurnit, Polak, Paz, Karlic, Rosa, Cuppen, Edwin, Danyi, Alexandra, de Ridder, Jeroen, van Herpen, Carla, Lolkema, Martijn P., Steeghs, Neeltje, Getz, Gad, Morris, Quaid D., Stein, Lincoln D.

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In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer von Pölcher, Martin, Rudlowski, Christian, Friedrichs, Nicolaus, Mielich, Marieke, Höller, Tobias, Wolfgarten, Mathias, Kübler, Kirsten, Büttner, Reinhard, Kuhn, Walther, Braun, Michael

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Sex differences in oncogenic mutational processes von Li, Constance H., Prokopec, Stephenie D., Sun, Ren X., Yousif, Fouad, Schmitz, Nathaniel, Boutros, Paul C.

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