A novel JAK/ROCK inhibitor, CPL409116, demonstrates potent efficacy in the mouse model of systemic lupus erythematosus von Dulak-Lis, Maria, Bujak, Anna, Gala, Kamila, Banach, Martyna, Kędzierska, Urszula, Miszkiel, Joanna, Hucz-Kalitowska, Joanna, Mroczkiewicz, Michał, Stypik, Bartosz, Szymczak, Krzysztof, Gunerka, Paweł, Dubiel, Krzysztof, Zygmunt, Beata M., Wieczorek, Maciej, Pieczykolan, Jerzy S.

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Tuning the Biological Activity of PI3K δ Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow von Pietruś, Wojciech, Stypik, Mariola, Zagozda, Marcin, Banach, Martyna, Gurba-Bryśkiewicz, Lidia, Maruszak, Wioleta, Leniak, Arkadiusz, Kurczab, Rafał, Ochal, Zbigniew, Dubiel, Krzysztof, Wieczorek, Maciej

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Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma von Gunerka, Paweł, Gala, Kamila, Banach, Martyna, Dominowski, Jakub, Hucz-Kalitowska, Joanna, Mulewski, Krzysztof, Hajnal, Agnes, Mikus, Endre G., Smuga, Damian, Zagozda, Marcin, Dubiel, Krzysztof, Pieczykolan, Jerzy, Zygmunt, Beata M., Wieczorek, Maciej

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Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists von Pankiewicz, Piotr, Szybiński, Marcin, Kisielewska, Katarzyna, Gołębiowski, Filip, Krzemiński, Patryk, Rutkowska-Włodarczyk, Izabela, Moszczyński-Pętkowski, Rafał, Gurba-Bryśkiewicz, Lidia, Delis, Monika, Mulewski, Krzysztof, Smuga, Damian, Dominowski, Jakub, Janusz, Artur, Górka, Michał, Abramski, Krzysztof, Napiórkowska, Agnieszka, Nowotny, Marcin, Dubiel, Krzysztof, Kalita, Katarzyna, Wieczorek, Maciej, Pieczykolan, Jerzy, Matłoka, Mikołaj

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Fast Claisen condensation reaction optimization in a continuous flow reactor von Michałek, Stanisław, Powała, Antoni, Gurba-Bryśkiewicz, Lidia, Piórkowska, Natalia, Olejkowska, Patrycja, Yamani, Abdellah, Ochal, Zbigniew, Dubiel, Krzysztof, Wieczorek, Maciej

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Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery von Gurba-Bryśkiewicz, Lidia, Maruszak, Wioleta, Smuga, Damian A., Dubiel, Krzysztof, Wieczorek, Maciej

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2333-PUB: CPL207-280, a Potent and Safe GPR40 Agonist for the treatment of Type 2 Diabetes von BAZYDLO-GUZENDA, KATARZYNA, BUDA, PAWEL, KOZLOWSKA, IZABELA, MACH, MATEUSZ, TESKA-KAMINSKA, MALGORZATA, STELMACH, FILIP, WASINSKA-KALWA, MALGORZATA, GALAZKA, KINGA, DUBIEL, KRZYSZTOF K., PIECZYKOLAN, JERZY S., WIECZOREK, MACIEJ

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Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives von Stypik, Mariola, Michałek, Stanisław, Orłowska, Nina, Zagozda, Marcin, Dziachan, Maciej, Banach, Martyna, Turowski, Paweł, Gunerka, Paweł, Zdżalik-Bielecka, Daria, Stańczak, Aleksandra, Kędzierska, Urszula, Mulewski, Krzysztof, Smuga, Damian, Maruszak, Wioleta, Gurba-Bryśkiewicz, Lidia, Leniak, Arkadiusz, Pietruś, Wojciech, Ochal, Zbigniew, Mach, Mateusz, Zygmunt, Beata, Pieczykolan, Jerzy, Dubiel, Krzysztof, Wieczorek, Maciej

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Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer von Popiel, Delfina, Stańczak, Aleksandra, Skupińska, Monika, Mikołajczyk, Agata, Stańczak, Paulina, Mituła, Filip, Hucz-Kalitowska, Joanna, Jastrzębska, Kinga, Smuga, Damian, Dominowski, Jakub, Delis, Monika, Mulewski, Krzysztof, Pietruś, Wojciech, Zdżalik-Bielecka, Daria, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Yamani, Abdellah, Olejkowska, Patrycja, Piórkowska, Natalia, Dubiel, Krzysztof, Wieczorek, Maciej, Pieczykolan, Jerzy

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Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives von Stypik, Mariola, Zagozda, Marcin, Michałek, Stanisław, Dymek, Barbara, Zdżalik-Bielecka, Daria, Dziachan, Maciej, Orłowska, Nina, Gunerka, Paweł, Turowski, Paweł, Hucz-Kalitowska, Joanna, Stańczak, Aleksandra, Stańczak, Paulina, Mulewski, Krzysztof, Smuga, Damian, Stefaniak, Filip, Gurba-Bryśkiewicz, Lidia, Leniak, Arkadiusz, Ochal, Zbigniew, Mach, Mateusz, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Dubiel, Krzysztof, Wieczorek, Maciej

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Discovery of TRAF-2 and NCK-interacting kinase (TNIK) inhibitors by ligand-based virtual screening methods von Bujak, Anna, Stefaniak, Filip, Zdzalik, Daria, Grygielewicz, Paulina, Dymek, Barbara, Zagozda, Marcin, Gunerka, Pawel, Lamparska-Przybysz, Monika, Dubiel, Krzysztof, Wieczorek, Maciej, Dzwonek, Karolina

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Development of the telescoped flow Pd-catalyzed aerobic alcohol oxidation/reductive amination sequence in the synthesis of new phosphatidylinositide 3-kinase inhibitor (CPL302415) von Micha ek, Stanis aw, Maj, Anna M, Gurba-Bry kiewicz, Lidia, Maruszak, Wioleta, Wi niewski, Krzysztof, Zagozda, Marcin, Stypik, Mariola, Dubiel, Krzysztof, Wieczorek, Maciej

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Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of... von Gurba-Bryśkiewicz, Lidia, Dawid, Urszula, Smuga, Damian A, Maruszak, Wioleta, Delis, Monika, Szymczak, Krzysztof, Stypik, Bartosz, Moroz, Aleksandra, Błocka, Aleksandra, Mroczkiewicz, Michał, Dubiel, Krzysztof, Wieczorek, Maciej

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Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3) von Yamani, Abdellah, Zdżalik-Bielecka, Daria, Lipner, Joanna, Stańczak, Aleksandra, Piórkowska, Natalia, Stańczak, Paulina Seweryna, Olejkowska, Patrycja, Hucz-Kalitowska, Joanna, Magdycz, Marta, Dzwonek, Karolina, Dubiel, Krzysztof, Lamparska-Przybysz, Monika, Popiel, Delfina, Pieczykolan, Jerzy, Wieczorek, Maciej

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Tuning the Biological Activity of PI3KIδ/I Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow von Pietruś, Wojciech, Stypik, Mariola, Zagozda, Marcin, Banach, Martyna, Gurba-Bryśkiewicz, Lidia, Maruszak, Wioleta, Leniak, Arkadiusz, Kurczab, Rafał, Ochal, Zbigniew, Dubiel, Krzysztof, Wieczorek, Maciej

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Discovery and development of CPL207280 as new GPR40/FFA1 agonist von Mach, Mateusz, Bazydło-Guzenda, Katarzyna, Buda, Paweł, Matłoka, Mikołaj, Dzida, Radosław, Stelmach, Filip, Gałązka, Kinga, Wąsińska-Kałwa, Małgorzata, Smuga, Damian, Hołowińska, Dagmara, Dawid, Urszula, Gurba-Bryśkiewicz, Lidia, Wiśniewski, Krzysztof, Dubiel, Krzysztof, Pieczykolan, Jerzy, Wieczorek, Maciej

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CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic An... von Bazydlo-Guzenda, Katarzyna, Buda, Pawel, Matloka, Mikolaj, Mach, Mateusz, Stelmach, Filip, Dzida, Radoslaw, Smuga, Damian, Hucz-Kalitowska, Joanna, Teska-Kaminska, Malgorzata, Vialichka, Varvara, Dubiel, Krzysztof, Kaminska, Bozena, Wieczorek, Maciej, Pieczykolan, Jerzy

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The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositi... von Micha ek, Stanis aw, Gurba-Bry kiewicz, Lidia, Maruszak, Wioleta, Zagozda, Marcin, Maj, Anna M, Ochal, Zbigniew, Dubiel, Krzysztof, Wieczorek, Maciej

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Guanidine Derivative ADS1017, a Potent Histamine H 3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile von Karcz, Tadeusz, Szczepańska, Katarzyna, Mogilski, Szczepan, Moroz, Aleksandra, Olejarz-Maciej, Agnieszka, Humphrys, Laura J, Pockes, Steffen, Siwek, Agata, Dubiel, Krzysztof, Staszewski, Marek, Calmels, Thierry, Waczyński, Krzysztof, Kieć-Kononowicz, Katarzyna

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Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile von Karcz, Tadeusz, Szczepańska, Katarzyna, Mogilski, Szczepan, Moroz, Aleksandra, Olejarz-Maciej, Agnieszka, Humphrys, Laura J., Pockes, Steffen, Siwek, Agata, Dubiel, Krzysztof, Staszewski, Marek, Calmels, Thierry, Waczyński, Krzysztof, Kieć-Kononowicz, Katarzyna

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