Structural Basis for G Protein-Coupled Receptor Activation von Manglik, Aashish, Kruse, Andrew C

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Crystal structure of the human σ1 receptor von Schmidt, Hayden R., Zheng, Sanduo, Gurpinar, Esin, Koehl, Antoine, Manglik, Aashish, Kruse, Andrew C.

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Protein design and variant prediction using autoregressive generative models von Shin, Jung-Eun, Riesselman, Adam J., Kollasch, Aaron W., McMahon, Conor, Simon, Elana, Sander, Chris, Manglik, Aashish, Kruse, Andrew C., Marks, Debora S.

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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody von Wingler, Laura M., McMahon, Conor, Staus, Dean P., Lefkowitz, Robert J., Kruse, Andrew C.

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Structural Basis for G Protein-Coupled Receptor Signaling von Erlandson, Sarah C, McMahon, Conor, Kruse, Andrew C

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Structural basis for σ1 receptor ligand recognition von Schmidt, Hayden R., Betz, Robin M., Dror, Ron O., Kruse, Andrew C.

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Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket von Zimmerman, Brandon, Kelly, Brendan, McMillan, Brian J., Seegar, Tom C.M., Dror, Ron O., Kruse, Andrew C., Blacklow, Stephen C.

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Yeast surface display platform for rapid discovery of conformationally selective nanobodies von McMahon, Conor, Baier, Alexander S., Pascolutti, Roberta, Wegrecki, Marcin, Zheng, Sanduo, Ong, Janice X., Erlandson, Sarah C., Hilger, Daniel, Rasmussen, Søren G. F., Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C.

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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor von Suomivuori, Carl-Mikael, Latorraca, Naomi R., Wingler, Laura M., Eismann, Stephan, King, Matthew C., Kleinhenz, Alissa L. W., Skiba, Meredith A., Staus, Dean P., Kruse, Andrew C., Lefkowitz, Robert J., Dror, Ron O.

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Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling von Paek, Jaeho, Kalocsay, Marian, Staus, Dean P., Wingler, Laura, Pascolutti, Roberta, Paulo, Joao A., Gygi, Steven P., Kruse, Andrew C.

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody von Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C., Enos, Michael D., Weis, William I., Garcia, K. Christopher, Kobilka, Brian K.

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Activation and allosteric modulation of a muscarinic acetylcholine receptor von Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist von Haga, Kazuko, Kruse, Andrew C., Asada, Hidetsugu, Yurugi-Kobayashi, Takami, Shiroishi, Mitsunori, Zhang, Cheng, Weis, William I., Okada, Tetsuji, Kobilka, Brian K., Haga, Tatsuya, Kobayashi, Takuya

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Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR von Wingler, Laura M., Skiba, Meredith A., McMahon, Conor, Staus, Dean P., Kleinhenz, Alissa L. W., Suomivuori, Carl-Mikael, Latorraca, Naomi R., Dror, Ron O., Lefkowitz, Robert J., Kruse, Andrew C.

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Structural basis of unidirectional export of lipopolysaccharide to the cell surface von Owens, Tristan W., Taylor, Rebecca J., Pahil, Karanbir S., Bertani, Blake R., Ruiz, Natividad, Kruse, Andrew C., Kahne, Daniel

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 von Tummino, Tia A., Rezelj, Veronica V., Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J., Monel, Blandine, Vallet, Thomas, White, Kris M., Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R., Lyu, Jiankun, Rosales, Romel, McGovern, Briana L., Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-Rene, Krogan, Nevan J., Urban, Laszlo, Shokat, Kevan M., Kruse, Andrew C., Garcia-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K.

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Structural Basis of Smoothened Activation in Hedgehog Signaling von Huang, Pengxiang, Zheng, Sanduo, Wierbowski, Bradley M., Kim, Youngchang, Nedelcu, Daniel, Aravena, Laura, Liu, Jing, Kruse, Andrew C., Salic, Adrian

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Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant von Pascolutti, Roberta, Sun, Xianqiang, Kao, Joseph, Maute, Roy L., Ring, Aaron M., Bowman, Gregory R., Kruse, Andrew C.

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A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery von Rohs, Patricia D A, Buss, Jackson, Sim, Sue I, Squyres, Georgia R, Srisuknimit, Veerasak, Smith, Mandy, Cho, Hongbaek, Sjodt, Megan, Kruse, Andrew C, Garner, Ethan C, Walker, Suzanne, Kahne, Daniel E, Bernhardt, Thomas G

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation von Staus, Dean P., Strachan, Ryan T., Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W., Kim, Tae Hun, Wingler, Laura M., Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C., Pardon, Els, Steyaert, Jan, Weis, William I., Prosser, R. Scott, Kobilka, Brian K., Costa, Tommaso, Lefkowitz, Robert J.

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