Enzymatic capture of an extrahelical thymine in the search for uracil in DNA von Stivers, James T, Parker, Jared B, Bianchet, Mario A, Krosky, Daniel J, Friedman, Joshua I, Amzel, L. Mario

Volltext

Virtual screening for early identification of potent and selective histone deacetylase 6 inhibitor series von Stachel, Shawn J., Wang, Deping, Ginnetti, Anthony T., Niroomand, Shahriar, Ma, Lei, Hu, YingHui, Fay, John F., Lemaire, Wei, Krosky, Daniel J., Ramirez, Andres D., Zariwala, Hatim A., Coleman, Paul J.

Volltext

Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV‑1 Integrase Inhibitors with Antiretroviral Activity von Burlein, Christine, Wang, Cheng, Xu, Min, Bhatt, Triveni, Stahlhut, Mark, Ou, Yangsi, Adam, Gregory C, Heath, Jeffrey, Klein, Daniel J, Sanders, John, Narayan, Kartik, Abeywickrema, Pravien, Heo, Mee Ra, Carroll, Steven S, Grobler, Jay A, Sharma, Sujata, Diamond, Tracy L, Converso, Antonella, Krosky, Daniel J

Volltext

Uracil-Directed Ligand Tethering:  An Efficient Strategy for Uracil DNA Glycosylase (UNG) Inhibitor Development von Jiang, Yu Lin, Krosky, Daniel J, Seiple, Lauren, Stivers, James T

Volltext

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase von Thalji, Reema K., McAtee, Jeff J., Belyanskaya, Svetlana, Brandt, Martin, Brown, Gregory D., Costell, Melissa H., Ding, Yun, Dodson, Jason W., Eisennagel, Steve H., Fries, Rusty E., Gross, Jeffrey W., Harpel, Mark R., Holt, Dennis A., Israel, David I., Jolivette, Larry J., Krosky, Daniel, Li, Hu, Lu, Quinn, Mandichak, Tracy, Roethke, Theresa, Schnackenberg, Christine G., Schwartz, Benjamin, Shewchuk, Lisa M., Xie, Wensheng, Behm, David J., Douglas, Stephen A., Shaw, Ami L., Marino, Joseph P.

Volltext

The Origins of High-Affinity Enzyme Binding to an Extrahelical DNA Base von Krosky, Daniel J, Song, Fenhong, Stivers, James T

Volltext

Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor von Diaz, Elsie, Adhikary, Suraj, Tepper, Armand W. J. W., Riley, Daniel, Ortiz-Meoz, Rodrigo, Krosky, Daniel, Buyck, Christophe, Lamenca, Carolina Martinez, Llaveria, Josep, Fang, Lichao, Kalin, Jay H., Klaren, Vincent N. A., Fahmy, Shorouk, Shaffer, Paul L., Kirkpatrick, Robert, Carbajo, Rodrigo J., Thomsen, Maren, Impagliazzo, Antonietta

Volltext

Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome von Yue, Tian-Li, Willette, Robert N., Hong, Victor S., Wu, Charlene W., Cui, Jianqi, Krosky, Daniel J., Costell, Melissa H., Schnackenberg, Christine G., Harpel, Mark R.

Volltext

The Catalytic Power of Uracil DNA Glycosylase in the Opening of Thymine Base Pairs von Cao, Chunyang, Jiang, Yu Lin, Krosky, Daniel J, Stivers, James T

Volltext

Linear Free Energy Correlations for Enzymatic Base Flipping:  How Do Damaged Base Pairs Facilitate Specific Recognition? von Krosky, Daniel J, Schwarz, Frederick P, Stivers, James T

Volltext

Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2 von Jiang, Yu Lin, Chung, Suhman, Krosky, Daniel J., Stivers, James T.

Volltext

Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays von Wang, Weixue, Krosky, Daniel, Ahn, Kay

Volltext

Mimicking damaged DNA with a small molecule inhibitor of human UNG2 von Krosky, Daniel J, Bianchet, Mario A, Seiple, Lauren, Chung, Suhman, Amzel, L. Mario, Stivers, James T

Volltext

Synthesis of biotinylated-LPG as a chemical biology tool enabling discovery of ALCAT1 modulators von Huang, Hui, Zhou, Renmei, Wen, He, Xu, Zhixiang, Zhang, Shengmei, Wang, Weixue, Krosky, Daniel, Miller, Robyn

Volltext

3-methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member von Stivers, James T, Drohat, Alexander C, Kwon, Keehwan, Krosky, Daniel J

Volltext

Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay von Wang, Weixue, Mevellec, Laurence, Liu, Annie, Struble, Geoff, Miller, Robyn, Allen, Samantha J, Federowicz, Kelly, Wroblowski, Berthold, Vialard, Jorge, Ahn, Kay, Krosky, Daniel

Volltext

Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity von Wang, Cheng, Adam, Gregory C., Burlein, Christine, Carroll, Steven, Dankulich, William, Diamond, Tracy, Grobler, Jay, Heath, Jeffrey, Johnson, Adam, Klein, Daniel, Krosky, Daniel, Narayan, Kartik, Ou, Yangsi, Sanders, John, Sharma, Sujata, Xu, Min, Converso, Antonella

Volltext

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia von Kwon, Min Chul, Querolle, Olivier, Dai, Xuedong, Thuring, Jan Willem, Verhulst, Tinne, Marien, Ann, Goffin, Dries, Cai, Wei, Keersmaekers, Vikki, Eyassu, Filmon, Verstraeten, Karin, El Ashkar, Sara, Hogeling, Shanna M, Jacob, Frank, Vinken, Petra, Darville, Nicolas, Pande, Vineet, Krosky, Daniel, Urbanietz, Gregor, Verbist, Bie, Ferrante, Lucille A., Drenberg, Christina Diane, Wilson, David, Attar, Ricardo M., Schuringa, Jan Jacob, Daskalakis, Nikki, Packman, Kathryn, Pietsch, Christine, Elsayed, Yusri, Philippar, Ulrike

Volltext

Development of a High-Throughput Cell-Based Assay for 11β-Hydroxysteroid Dehydrogenase Type 1 Using BacMam Technology von Wang, Da-Yuan, Lu, Quinn, Walsh, Stacey L., Payne, Lisa, Modha, Sundip S., Scott, Martin J., Sweitzer, Thomas D., Ames, Robert S., Krosky, Daniel J., Li, Hu

Volltext

Structural characterization of nonactive site, TrkA-selective kinase inhibitors von Su, Hua-Poo, Rickert, Keith, Burlein, Christine, Narayan, Kartik, Bukhtiyarova, Marina, Hurzy, Danielle M., Stump, Craig A., Zhang, Xufang, Reid, John, Krasowska-Zoladek, Alicja, Tummala, Srivanya, Shipman, Jennifer M., Kornienko, Maria, Lemaire, Peter A., Krosky, Daniel, Heller, Amanda, Achab, Abdelghani, Chamberlin, Chad, Saradjian, Peter, Sauvagnat, Berengere, Yang, Xianshu, Ziebell, Michael R., Nickbarg, Elliott, Sanders, John M., Bilodeau, Mark T., Carroll, Steven S., Lumb, Kevin J., Soisson, Stephen M., Henze, Darrell A., Cooke, Andrew J.

Volltext