85 TARGETING THE DYSMETABOLIC SYNDROME IN A CARDIOVASCULAR DISEASE DIABETIC COHORT WITH ROSIGLITAZONE: 1 YEAR ANALYSIS von Aguinaldo, M., Kronstad, D., Cole, C., Lyko, A., Chao, E., Daud, S., Krishnamoorthy, S., Vu, K., Liu, W., Magbual, R., Petrofsky, J., Lee, S.

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223 IMPROVEMENTS IN CAROTID ARTERY INTIMA-MEDIA THICKNESS IN TYPE 2 DIABETIC PATIENTS USING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ LIGAND, ROSIGLITAZONE von Kronstad, D., Cole, C., Aguinaldo, M., Lyko, A., Chao, E., Daud, S., Krishnamoorthy, S., Vu, K., Magbual, R., Liu, W., Lee, S.

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Improvements in Carotid Artery Intima-Media Thickness in Type 2 Diabetic Patients Using Peroxisome Proliferator-Activated Receptor Γ Ligand, Rosiglitazone von Kronstad, D., Cole, C., Aguinaldo, M., Lyko, A., Chao, E., Daud, S., Krishnamoorthy, S., Vu, K., Magbual, R., Liu, W., Lee, S.

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223 IMPROVEMENTS IN CAROTID ARTERY INTIMA-MEDIA THICKNESS IN TYPE 2 DIABETIC PATIENTS USING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR [GAMMA] LIGAND, ROSIGLITAZONE von Kronstad, D, Cole, C, Aguinaldo, M, Lyko, A, Chao, E, Daud, S, Krishnamoorthy, S, Vu, K, Magbual, R, Liu, W, Lee, S

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Targeting the Dysmetabolic Syndrome in a Cardiovascular Disease Diabetic Cohort with Rosiglitazone: 1 Year Analysis von Aguinaldo, M., Kronstad, D., Cole, C., Lyko, A., Chao, E., Daud, S., Krishnamoorthy, S., Vu, K., Liu, W., Magbual, R., Petrofsky, J., Lee, S.

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Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers von Allert, Stefanie, Förster, Toni M, Svensson, Carl-Magnus, Richardson, Jonathan P, Pawlik, Tony, Hebecker, Betty, Rudolphi, Sven, Juraschitz, Marc, Schaller, Martin, Blagojevic, Mariana, Morschhäuser, Joachim, Figge, Marc Thilo, Jacobsen, Ilse D, Naglik, Julian R, Kasper, Lydia, Mogavero, Selene, Hube, Bernhard

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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs von Gobeil, Sophie M-C, Bobay, Benjamin G, Juvvadi, Praveen R, Cole, D Christopher, Heitman, Joseph, Steinbach, William J, Venters, Ronald A, Spicer, Leonard D

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High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis von O'Meara, Teresa R, Duah, Kwamaa, Guo, Cynthia X, Maxson, Michelle E, Gaudet, Ryan G, Koselny, Kristy, Wellington, Melanie, Powers, Michael E, MacAlpine, Jessie, O'Meara, Matthew J, Veri, Amanda O, Grinstein, Sergio, Noble, Suzanne M, Krysan, Damian, Gray-Owen, Scott D, Cowen, Leah E

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Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture von Fisher, Matthew C, Gurr, Sarah J, Cuomo, Christina A, Blehert, David S, Jin, Hailing, Stukenbrock, Eva H, Stajich, Jason E, Kahmann, Regine, Boone, Charles, Denning, David W, Gow, Neil A R, Klein, Bruce S, Kronstad, James W, Sheppard, Donald C, Taylor, John W, Wright, Gerard D, Heitman, Joseph, Casadevall, Arturo, Cowen, Leah E

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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus von Hoy, Michael J, Park, Eunchong, Lee, Hyunji, Lim, Won Young, Cole, D Christopher, DeBouver, Nicholas D, Bobay, Benjamin G, Pierce, Phillip G, Fox, 3rd, David, Ciofani, Maria, Juvvadi, Praveen R, Steinbach, William, Hong, Jiyong, Heitman, Joseph

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A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets von Zamith-Miranda, Daniel, Heyman, Heino M, Burnet, Meagan C, Couvillion, Sneha P, Zheng, Xueyun, Munoz, Nathalie, Nelson, William C, Kyle, Jennifer E, Zink, Erika M, Weitz, Karl K, Bloodsworth, Kent J, Clair, Geremy, Zucker, Jeremy D, Teuton, Jeremy R, Payne, Samuel H, Kim, Young-Mo, Reyes Gil, Morayma, Baker, Erin S, Bredeweg, Erin L, Nosanchuk, Joshua D, Nakayasu, Ernesto S

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A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection von Palmucci, Julia R, Sells, Blake E, Giamberardino, Charles D, Toffaletti, Dena L, Dai, Baodi, Asfaw, Yohannes G, Dubois, Laura G, Li, Zhong, Theriot, Barbara, Schell, Wiley A, Hope, William, Tenor, Jennifer L, Perfect, John R

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Dynamic calcium-mediated stress response and recovery signatures in the fungal pathogen, Candida albicans von Giuraniuc, C V, Parkin, C, Almeida, M C, Fricker, M, Shadmani, P, Nye, S, Wehmeier, S, Chawla, S, Bedekovic, T, Lehtovirta-Morley, L, Richards, D M, Gow, N A, Brand, A C

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Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis von Giamberardino, Charles D, Schell, Wiley A, Tenor, Jennifer L, Toffaletti, Dena L, Palmucci, Julia R, Marius, Choiselle, Boua, Jane-Valeriane K, Soltow, Quinlyn, Mansbach, Robert, Moseley, M Arthur, Thompson, J Will, Dubois, Laura G, Hope, William, Perfect, John R, Shaw, Karen Joy

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Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway von Stewart, James I P, Fava, Vinicius M, Kerkaert, Joshua D, Subramanian, Adithya S, Gravelat, Fabrice N, Lehoux, Melanie, Howell, P Lynne, Cramer, Robert A, Sheppard, Donald C

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Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells von Davis, Michael J, Moyer, Shannon, Hoke, Elizabeth S, Sionov, Edward, Mayer-Barber, Katrin D, Barber, Dan L, Cai, Hongyi, Jenkins, Lisa, Walter, Peter J, Chang, Yun C, Kwon-Chung, Kyung J

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Iron source preference and regulation of iron uptake in Cryptococcus neoformans von Jung, Won Hee, Sham, Anita, Lian, Tianshun, Singh, Arvinder, Kosman, Daniel J, Kronstad, James W

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The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans von Horianopoulos, Linda C, Hu, Guanggan, Caza, Mélissa, Schmitt, Kerstin, Overby, Peter, Johnson, James D, Valerius, Oliver, Braus, Gerhard H, Kronstad, James W

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Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation von Geddes, J M H, Caza, M, Croll, D, Stoynov, N, Foster, L J, Kronstad, J W

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The future of fungi: threats and opportunities von Case, Nicola T, Berman, Judith, Blehert, David S, Cramer, Robert A, Cuomo, Christina, Currie, Cameron R, Ene, Iuliana V, Fisher, Matthew C, Fritz-Laylin, Lillian K, Gerstein, Aleeza C, Glass, N Louise, Gow, Neil A R, Gurr, Sarah J, Hittinger, Chris Todd, Hohl, Tobias M, Iliev, Iliyan D, James, Timothy Y, Jin, Hailing, Klein, Bruce S, Kronstad, James W, Lorch, Jeffrey M, McGovern, Victoria, Mitchell, Aaron P, Segre, Julia A, Shapiro, Rebecca S, Sheppard, Donald C, Sil, Anita, Stajich, Jason E, Stukenbrock, Eva E, Taylor, John W, Thompson, Dawn, Wright, Gerard D, Heitman, Joseph, Cowen, Leah E

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