High-Throughput Reclassification of SCN5A Variants von Glazer, Andrew M., Wada, Yuko, Li, Bian, Muhammad, Ayesha, Kalash, Olivia R., O’Neill, Matthew J., Shields, Tiffany, Hall, Lynn, Short, Laura, Blair, Marcia A., Kroncke, Brett M., Capra, John A., Roden, Dan M.

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A Bayesian method to estimate variant-induced disease penetrance von Kroncke, Brett M., Smith, Derek K., Zuo, Yi, Glazer, Andrew M., Roden, Dan M., Blume, Jeffrey D.

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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1 von Kozek, Krystian A., Glazer, Andrew M., Ng, Chai-Ann, Blackwell, Daniel, Egly, Christian L., Vanags, Loren R., Blair, Marcia, Mitchell, Devyn, Matreyek, Kenneth A., Fowler, Douglas M., Knollmann, Bjorn C., Vandenberg, Jamie I., Roden, Dan M., Kroncke, Brett M.

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A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel von Johnson, Christopher N., Potet, Franck, Thompson, Matthew K., Kroncke, Brett M., Glazer, Andrew M., Voehler, Markus W., Knollmann, Bjorn C., George, Alfred L., Chazin, Walter J.

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Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5 von Gulsevin, Alican, Glazer, Andrew M., Shields, Tiffany, Kroncke, Brett M., Roden, Dan M., Meiler, Jens

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The Homology Model of PMP22 Suggests Mutations Resulting in Peripheral Neuropathy Disrupt Transmembrane Helix Packing von Mittendorf, Kathleen F, Kroncke, Brett M, Meiler, Jens, Sanders, Charles R

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Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay von Thomson, Kate L., Jiang, Connie, Richardson, Ebony, Westphal, Dominik S., Burkard, Tobias, Wolf, Cordula M., Vatta, Matteo, Harrison, Steven M., Ingles, Jodie, Bezzina, Connie R., Kroncke, Brett M., Vandenberg, Jamie I., Ng, Chai-Ann

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Mapping Membrane Protein Backbone Dynamics: A Comparison of Site-Directed Spin Labeling with NMR 15N-Relaxation Measurements von Lo, Ryan H., Kroncke, Brett M., Solomon, Tsega L., Columbus, Linda

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Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1 von Kroncke, Brett M., Mendenhall, Jeffrey, Smith, Derek K., Sanders, Charles R., Capra, John A., George, Alfred L., Blume, Jeffrey D., Meiler, Jens, Roden, Dan M.

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Structural basis for KCNE3 modulation of potassium recycling in epithelia von Kroncke, Brett M, Van Horn, Wade D, Smith, Jarrod, Kang, CongBao, Welch, Richard C, Song, Yuanli, Nannemann, David P, Taylor, Keenan C, Sisco, Nicholas J, George, Jr, Alfred L, Meiler, Jens, Vanoye, Carlos G, Sanders, Charles R

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Multiple mechanisms underlie increased cardiac late sodium current von Kroncke, Brett M., Yang, Tao, Roden, Dan M.

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A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2 von Ng, Chai-Ann, Ullah, Rizwan, Farr, Jessica, Hill, Adam P, Kozek, Krystian A, Vanags, Loren R, Mitchell, Devyn W, Kroncke, Brett M, Vandenberg, Jamie I

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A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome von Jiang, Connie, Richardson, Ebony, Farr, Jessica, Hill, Adam P, Ullah, Rizwan, Kroncke, Brett M, Harrison, Steven M, Thomson, Kate L, Ingles, Jodie, Vandenberg, Jamie I, Ng, Chai-Ann

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DEER EPR Measurements for Membrane Protein Structures via Bifunctional Spin Labels and Lipodisq Nanoparticles von Sahu, Indra D, McCarrick, Robert M, Troxel, Kaylee R, Zhang, Rongfu, Smith, Hubbell J, Dunagan, Megan M, Swartz, Max S, Rajan, Prashant V, Kroncke, Brett M, Sanders, Charles R, Lorigan, Gary A

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Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability von Kroncke, Brett M, Duran, Amanda M, Mendenhall, Jeffrey L, Meiler, Jens, Blume, Jeffrey D, Sanders, Charles R

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Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome von Chavali, Nikhil V., Kryshtal, Dmytro O., Parikh, Shan S., Wang, Lili, Glazer, Andrew M., Blackwell, Daniel J., Kroncke, Brett M., Shoemaker, Moore Benjamin, Knollmann, Bjorn C.

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Structural Origins of Nitroxide Side Chain Dynamics on Membrane Protein α-Helical Sites von Kroncke, Brett M, Horanyi, Peter S, Columbus, Linda

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Structure of the Neisserial Outer Membrane Protein Opa60: Loop Flexibility Essential to Receptor Recognition and Bacterial Engulfment von Fox, Daniel A, Larsson, Per, Lo, Ryan H, Kroncke, Brett M, Kasson, Peter M, Columbus, Linda

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Continuous Bayesian variant interpretation accounts for incomplete penetrance among Mendelian cardiac channelopathies von O’Neill, Matthew J., Sala, Luca, Denjoy, Isabelle, Wada, Yuko, Kozek, Krystian, Crotti, Lia, Dagradi, Federica, Kotta, Maria-Christina, Spazzolini, Carla, Leenhardt, Antoine, Salem, Joe-Elie, Kashiwa, Asami, Ohno, Seiko, Tao, Ran, Roden, Dan M., Horie, Minoru, Extramiana, Fabrice, Schwartz, Peter J., Kroncke, Brett M.

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Assays of Variant Effect and Automated Patch Clamping Improve KCNH2 -LQTS Variant Classification and Cardiac Event Risk Stratification von O'Neill, Matthew J, Ng, Chai-Ann, Aizawa, Takanori, Sala, Luca, Bains, Sahej, Winbo, Annika, Ullah, Rizwan, Shen, Qianyi, Tan, Chek-Ying, Kozek, Krystian, Vanags, Loren R, Mitchell, Devyn W, Shen, Alex, Wada, Yuko, Kashiwa, Asami, Crotti, Lia, Dagradi, Federica, Musu, Giulia, Spazzolini, Carla, Neves, Raquel, Bos, J Martijn, Giudicessi, John R, Bledsoe, Xavier, Gamazon, Eric R, Lancaster, Megan C, Glazer, Andrew M, Knollmann, Bjorn C, Roden, Dan M, Weile, Jochen, Roth, Frederick, Salem, Joe-Elie, Earle, Nikki, Stiles, Rachael, Agee, Taylor, Johnson, Christopher N, Horie, Minoru, Skinner, Jonathan, Ackerman, Michael J, Schwartz, Peter J, Ohno, Seiko, Vandenberg, Jamie I, Kroncke, Brett M

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