P967: TUMOR BURDEN AS A CRITICAL PROGNOSTIC FACTOR OF PRIMARY EXTRAMEDULLARY DISEASE von Vlachová, M., Štork, M., Ševčíková, S., Jelínek, T., Minařík, J., Radocha, J., Krhovská, P., Pospíšilová, L., Špička, I., Straub, J., Pavlíček, P., Jungová, A., Sandecká, V., Maisnar, V., Hájek, R., Pour, L.

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The relationship between serum levels of selected biomarkers of bone marrow microenvironment and the activity of multiple myeloma von Proskova, J., Krhovska, P., Hermanova, Z., Petrova, P., Pika, T., Bacovsky, J., Minarik, J.

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20 Years of Transplant Program in Multiple Myeloma - a Single Centre Experience von Minarik, Jiri, Faber, Edgar, Raida, Ludek, Szotkowski, Tomas, Bacovsky, Jaroslav, Pika, Tomas, Skoumalova, Ivana, Krhovska, Petra, Zapletalova, Jana, Papajik, Tomas, Scudla, Vlastimil

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Single Agent Daratumumab in Advanced Multiple Myeloma: Specific Healthcare Program in the Czech Republic von Minarik, Jiri, Pour, Ludek, Maisnar, Vladimir, Spicka, Ivan, Jungova, Alexandra, Plonkova, Hana, Brozova, Lucie, Krhovska, Petra, Pika, Tomas, Bacovsky, Jaroslav, Sevcikova, Sabina, Radocha, Jakub, Scudla, Vlastimil, Hájek, Roman

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PS1365 NEXT‐GENERATION OPTICAL MAPPING REVEALS LARGE GENETIC HETEROGENEITY IN MULTIPLE MYELOMA von Petrackova, A., Fillerova, R., Minarik, J., Mikulkova, Z., Balcarkova, J., Krhovska, P., Pika, T., Gajdos, P., Behalek, M., Papajik, T., Kriegova, E.

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Diagnostic deep‐targeted next‐generation sequencing assessment of TP53 gene mutations in multiple myeloma from the whole bone marrow von Petrackova, Anna, Minarik, Jiri, Sedlarikova, Lenka, Libigerova, Tereza, Hamplova, Alzbeta, Krhovska, Petra, Balcarkova, Jana, Pika, Tomas, Papajik, Tomas, Kriegova, Eva

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Ixazomib, Lenalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma in Routine Clinical Practice: Extended Follow-Up Analysis and the Results of Subsequent Therapy von Minarik, Jiri, Radocha, Jakub, Jungova, Alexandra, Straub, Jan, Jelinek, Tomas, Pika, Tomas, Pour, Ludek, Pavlicek, Petr, Harvanova, Lubica, Pospisilova, Lenka, Krhovska, Petra, Novakova, Denisa, Jindra, Pavel, Spicka, Ivan, Plonkova, Hana, Stork, Martin, Bacovsky, Jaroslav, Maisnar, Vladimir, Hajek, Roman

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Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures von Dunphy, Katie, Bazou, Despina, Henry, Michael, Meleady, Paula, Miettinen, Juho J, Heckman, Caroline A, Dowling, Paul, O'Gorman, Peter

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Updated Perspectives on the Management of Relapsed and Refractory Multiple Myeloma von Heimberg, Linda, Knop, Stefan

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Feasibility of Optical Genome Mapping in Cytogenetic Diagnostics of Hematological Neoplasms: A New Way to Look at DNA von Coccaro, Nicoletta, Anelli, Luisa, Zagaria, Antonella, Tarantini, Francesco, Cumbo, Cosimo, Tota, Giuseppina, Minervini, Crescenzio Francesco, Minervini, Angela, Conserva, Maria Rosa, Redavid, Immacolata, Parciante, Elisa, Macchia, Maria Giovanna, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco

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Breakthrough COVID-19 in Vaccinated Patients with Haematologic Malignancies-The First Single-Centre Experience from the Czech Republic von Čerňan, Martin, Szotkowski, Tomáš, Minařík, Jiří, Kolář, Milan, Sauer, Pavel, Látal, Vojtěch, Zapletalová, Jana, Papajík, Tomáš

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Genetic Abnormalities in Extramedullary Multiple Myeloma von McAvera, Roisin, Quinn, John, Murphy, Philip, Glavey, Siobhan

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Optical Genome Mapping in Routine Human Genetic Diagnostics-Its Advantages and Limitations von Dremsek, Paul, Schwarz, Thomas, Weil, Beatrix, Malashka, Alina, Laccone, Franco, Neesen, Jürgen

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Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma von Vlachová, Monika, Gregorová, Jana, Vychytilová-Faltejsková, Petra, Gabło, Natalia Anna, Radová, Lenka, Pospíšilová, Lenka, Almáši, Martina, Štork, Martin, Knechtová, Zdeňka, Minařík, Jiří, Popková, Tereza, Jelínek, Tomáš, Hájek, Roman, Pour, Luděk, Říhová, Lucie, Ševčíková, Sabina

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First-Line Use of Daratumumab in Patients with Multiple Myeloma Shows Delayed Neutrophil and Platelet Engraftment after Autologous Stem Cell Transplantation: Results from a Real-Li... von Martino, Massimo, Gori, Mercedes, Porto, Gaetana, Policastro, Giorgia, Pitea, Martina, Sgarlata, Annalisa, Delfino, Ilaria Maria, Cogliandro, Francesca, Scopelliti, Anna, Utano, Giovanna, Pellicano, Maria, Idato, Aurora, Vincelli, Iolanda Donatella, Marafioti, Violetta, Micò, Maria Caterina, Lazzaro, Giuseppe, Loteta, Barbara, Alati, Caterina, Leanza, Giovanni, D'Arrigo, Graziella, Tripepi, Giovanni Luigi, Pitino, Annalisa

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Metabolic Disorders in Multiple Myeloma von Gavriatopoulou, Maria, Paschou, Stavroula A, Ntanasis-Stathopoulos, Ioannis, Dimopoulos, Meletios A

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Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery von Mehl, Julian, Akhoundova, Dilara, Bacher, Ulrike, Jeker, Barbara, Rhyner Agocs, Gaëlle, Ruefer, Axel, Soltermann, Susanne, Soekler, Martin, Winkler, Annette, Daskalakis, Michael, Pabst, Thomas

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Analysis of High-Risk Extramedullary Relapse Factors in Newly Diagnosed MM Patients von Yue, Xiaoyan, He, Donghua, Zheng, Gaofeng, Yang, Yang, Han, Xiaoyan, Li, Yi, Zhao, Yi, Wu, Wenjun, Chen, Qingxiao, Zhang, Enfang, Cai, Zhen, He, Jingsong

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Impact of Anti-CD38 Monoclonal Antibody Therapy on CD34+ Hematopoietic Stem Cell Mobilization, Collection, and Engraftment in Multiple Myeloma Patients-A Systematic Review von Bigi, Flavia, Manzato, Enrica, Barbato, Simona, Talarico, Marco, Puppi, Michele, Masci, Simone, Sacchetti, Ilaria, Restuccia, Roberta, Iezza, Miriam, Rizzello, Ilaria, Sartor, Chiara, Mancuso, Katia, Pantani, Lucia, Tacchetti, Paola, Cavo, Michele, Zamagni, Elena

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FcγR-Mediated Trogocytosis 2.0: Revisiting History Gives Rise to a Unifying Hypothesis von Lindorfer, Margaret A, Taylor, Ronald P

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