Structural basis for allosteric PARP-1 retention on DNA breaks von Zandarashvili, Levani, Langelier, Marie-France, Velagapudi, Uday Kiran, Hancock, Mark A., Steffen, Jamin D., Billur, Ramya, Hannan, Zain M., Wicks, Andrew J., Krastev, Dragomir B., Pettitt, Stephen J., Lord, Christopher J., Talele, Tanaji T., Pascal, John M., Black, Ben E.

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance von Pettitt, Stephen J., Krastev, Dragomir B., Brandsma, Inger, Dréan, Amy, Song, Feifei, Aleksandrov, Radoslav, Harrell, Maria I., Menon, Malini, Brough, Rachel, Campbell, James, Frankum, Jessica, Ranes, Michael, Pemberton, Helen N., Rafiq, Rumana, Fenwick, Kerry, Swain, Amanda, Guettler, Sebastian, Lee, Jung-Min, Swisher, Elizabeth M., Stoynov, Stoyno, Yusa, Kosuke, Ashworth, Alan, Lord, Christopher J.

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Mammalian Ino80 Mediates Double-Strand Break Repair through Its Role in DNA End Strand Resection von Gospodinov, Anastas, Vaissiere, Thomas, Krastev, Dragomir B., Legube, Gaëlle, Anachkova, Boyka, Herceg, Zdenko

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Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets von Krastev, Dragomir B., Pettitt, Stephen J., Campbell, James, Song, Feifei, Tanos, Barbara E., Stoynov, Stoyno S., Ashworth, Alan, Lord, Christopher J.

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ATR Is a Therapeutic Target in Synovial Sarcoma von Jones, Samuel E, Fleuren, Emmy D G, Frankum, Jessica, Konde, Asha, Williamson, Chris T, Krastev, Dragomir B, Pemberton, Helen N, Campbell, James, Gulati, Aditi, Elliott, Richard, Menon, Malini, Selfe, Joanna L, Brough, Rachel, Pettitt, Stephen J, Niedzwiedz, Wojciech, van der Graaf, Winette T A, Shipley, Janet, Ashworth, Alan, Lord, Christopher J

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A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia von Słabicki, Mikołaj, Theis, Mirko, Krastev, Dragomir B, Samsonov, Sergey, Mundwiller, Emeline, Junqueira, Magno, Paszkowski-Rogacz, Maciej, Teyra, Joan, Heninger, Anne-Kristin, Poser, Ina, Prieur, Fabienne, Truchetto, Jérémy, Confavreux, Christian, Marelli, Cécilia, Durr, Alexandra, Camdessanche, Jean Philippe, Brice, Alexis, Shevchenko, Andrej, Pisabarro, M Teresa, Stevanin, Giovanni, Buchholz, Frank

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Opinion: PARP inhibitors in cancer-what do we still need to know? von Wicks, Andrew J, Krastev, Dragomir B, Pettitt, Stephen J, Tutt, Andrew N J, Lord, Christopher J

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Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7 von Baxter, Joseph S., Brough, Rachel, Krastev, Dragomir B., Song, Feifei, Sridhar, Sandhya, Gulati, Aditi, Alexander, John, Roumeliotis, Theodoros I., Kozik, Zuza, Choudhary, Jyoti S., Haider, Syed, Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells von Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N.J., Rottenberg, Sven, Lord, Christopher J.

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PARP Inhibitors - Trapped in a Toxic Love Affair von Krastev, Dragomir B., Wicks, Andrew J., Lord, Christopher J.

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The shieldin complex mediates 53BP1-dependent DNA repair von Noordermeer, Sylvie M., Adam, Salomé, Setiaputra, Dheva, Barazas, Marco, Pettitt, Stephen J., Ling, Alexanda K., Olivieri, Michele, Álvarez-Quilón, Alejandro, Moatti, Nathalie, Zimmermann, Michal, Annunziato, Stefano, Krastev, Dragomir B., Song, Feifei, Brandsma, Inger, Frankum, Jessica, Brough, Rachel, Sherker, Alana, Landry, Sébastien, Szilard, Rachel K., Munro, Meagan M., McEwan, Andrea, Goullet de Rugy, Théo, Lin, Zhen-Yuan, Hart, Traver, Moffat, Jason, Gingras, Anne-Claude, Martin, Alberto, van Attikum, Haico, Jonkers, Jos, Lord, Christopher J., Rottenberg, Sven, Durocher, Daniel

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PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer von Chabanon, Roman M, Muirhead, Gareth, Krastev, Dragomir B, Adam, Julien, Morel, Daphné, Garrido, Marlène, Lamb, Andrew, Hénon, Clémence, Dorvault, Nicolas, Rouanne, Mathieu, Marlow, Rebecca, Bajrami, Ilirjana, Cardeñosa, Marta Llorca, Konde, Asha, Besse, Benjamin, Ashworth, Alan, Pettitt, Stephen J, Haider, Syed, Marabelle, Aurélien, Tutt, Andrew Nj, Soria, Jean-Charles, Lord, Christopher J, Postel-Vinay, Sophie

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Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery von Rouleau-Turcotte, Élise, Krastev, Dragomir B., Pettitt, Stephen J., Lord, Christopher J., Pascal, John M.

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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency von Bajrami, Ilirjana, Walker, Callum, Krastev, Dragomir B., Weekes, Daniel, Song, Feifei, Wicks, Andrew J., Alexander, John, Haider, Syed, Brough, Rachel, Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.

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Ribosome biogenesis and p53: Who is regulating whom? von Krastev, Dragomir B., Buchholz, Frank

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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin von Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.

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Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells von Pettitt, Stephen J., Krastev, Dragomir B., Pemberton, Helen N., Fontebasso, Yari, Frankum, Jessica, Rehman, Farah L., Brough, Rachel, Song, Feifei, Bajrami, Ilirjana, Rafiq, Rumana, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Armisen-Garrido, Javier, Swain, Amanda, Gulati, Aditi, Campbell, James, Ashworth, Alan, Lord, Christopher J.

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SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance von Llorca-Cardenosa, Marta J, Aronson, Lauren I, Krastev, Dragomir B, Nieminuszczy, Jadwiga, Alexander, John, Song, Feifei, Dylewska, Malgorzata, Broderick, Ronan, Brough, Rachel, Zimmermann, Astrid, Zenke, Frank T, Gurel, Bora, Riisnaes, Ruth, Ferreira, Ana, Roumeliotis, Theodoros, Choudhary, Jyoti, Pettitt, Stephen J, de Bono, Johann, Cervantes, Andres, Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J, Chong, Irene Y

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A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant von Pettitt, Stephen J., Shao, Nan, Zatreanu, Diana, Frankum, Jessica, Bajrami, Ilirjana, Brough, Rachel, Krastev, Dragomir B., Roumeliotis, Theodoros I., Choudhary, Jyoti S., Lorenz, Sonja, Rust, Alistair, de Bono, Johann S., Yap, Timothy A., Tutt, Andrew N. J., Lord, Christopher J.

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E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer von Bajrami, Ilirjana, Marlow, Rebecca, van de Ven, Marieke, Brough, Rachel, Pemberton, Helen N, Frankum, Jessica, Song, Feifei, Rafiq, Rumana, Konde, Asha, Krastev, Dragomir B, Menon, Malini, Campbell, James, Gulati, Aditi, Kumar, Rahul, Pettitt, Stephen J, Gurden, Mark D, Cardenosa, Marta Llorca, Chong, Irene, Gazinska, Patrycja, Wallberg, Fredrik, Sawyer, Elinor J, Martin, Lesley-Ann, Dowsett, Mitch, Linardopoulos, Spiros, Natrajan, Rachael, Ryan, Colm J, Derksen, Patrick W B, Jonkers, Jos, Tutt, Andrew N J, Ashworth, Alan, Lord, Christopher J

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