Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer von Ross, Breyan, Krapp, Stephan, Augustin, Martin, Kierfersauer, Reiner, Arciniega, Marcelino, Geiss-Friedlander, Ruth, Huber, Robert

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Structural Basis for the Activation of Human Procaspase-7 von Riedl, Stefan J., Fuentes-Prior, Pablo, Renatus, Martin, Kairies, Norman, Krapp, Stephan, Huber, Robert, Salvesen, Guy S., Bode, Wolfram

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Open and Closed Structures of the UDP-glucose Pyrophosphorylase from Leishmania major von Steiner, Thomas, Lamerz, Anne-Christin, Hess, Petra, Breithaupt, Constanze, Krapp, Stephan, Bourenkov, Gleb, Huber, Robert, Gerardy-Schahn, Rita, Jacob, Uwe

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Aerosol‐based ligand soaking of reservoir‐free protein crystals von Ross, Breyan, Krapp, Stephan, Geiss-Friedlander, Ruth, Littmann, Walter, Huber, Robert, Kiefersauer, Reiner

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The Crystal Structure of Murine CMP-5- N-acetylneuraminic Acid Synthetase von Krapp, Stephan, Münster-Kühnel, Anja K., Kaiser, Jens T., Huber, Robert, Tiralongo, Joe, Gerardy-Schahn, Rita, Jacob, Uwe

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DPP8 and DPP9 structure, mechanism and interaction with SUMO1 von Ross, Breyan, Krapp, Stephan, Geiss-Friedlander, Ruth, Huber, Robert

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β‑Glucocerebrosidase Modulators Promote Dimerization of β‑Glucocerebrosidase and Reveal an Allosteric Binding Site von Zheng, Jianbin, Chen, Long, Skinner, Owen S, Ysselstein, Daniel, Remis, Jonathan, Lansbury, Peter, Skerlj, Renato, Mrosek, Michael, Heunisch, Ursula, Krapp, Stephan, Charrow, Joel, Schwake, Michael, Kelleher, Neil L, Silverman, Richard B, Krainc, Dimitri

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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry von Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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Crystal transformation using IR laser radiation von Ross, Breyan H., Stahl, Evi, Krapp, Stephan, Huber, Robert, Kiefersauer, Reiner A.

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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors von Crawford, James J, Kenny, Peter W, Bowyer, Jonathan, Cook, Calum R, Finlayson, Jonathan E, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McDermott, Benjamin P, McGuire, Thomas M, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Dossetter, Alexander G

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Dipeptidyl nitrile inhibitors of Cathepsin L von Asaad, Nabil, Bethel, Paul A., Coulson, Michelle D., Dawson, Jack E., Ford, Susannah J., Gerhardt, Stefan, Grist, Matthew, Hamlin, Gordon A., James, Michael J., Jones, Emma V., Karoutchi, Galith I., Kenny, Peter W., Morley, Andrew D., Oldham, Keith, Rankine, Neil, Ryan, David, Wells, Stuart L., Wood, Linda, Augustin, Martin, Krapp, Stephan, Simader, Hannes, Steinbacher, Stefan

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Design of selective Cathepsin inhibitors von Bethel, Paul A., Gerhardt, Stefan, Jones, Emma V., Kenny, Peter W., Karoutchi, Galith I., Morley, Andrew D., Oldham, Keith, Rankine, Neil, Augustin, Martin, Krapp, Stephan, Simader, Hannes, Steinbacher, Stefan

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Structure and function of vertebrate CMP–sialic acid synthetases von Münster-Kühnel, Anja K., Tiralongo, Joe, Krapp, Stephan, Weinhold, Birgit, Ritz-Sedlacek, Valentina, Jacob, Uwe, Gerardy-Schahn, Rita

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High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors von Fradera, Xavier, Kazemier, Bert, Carswell, Emma, Cooke, Andrew, Oubrie, Arthur, Hamilton, William, Dempster, Maureen, Krapp, Stephan, Nagel, Susanna, Jestel, Anja

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition von Dossetter, Alexander G., Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Krapp, Stephan, MacFaul, Philip A., McGuire, Thomas M., Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline

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Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology von Böttcher, Jark, Jestel, Anja, Kiefersauer, Reiner, Krapp, Stephan, Nagel, Susanna, Steinbacher, Stefan, Steuber, Holger

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IR laser-induced protein crystal transformation von Kiefersauer, Reiner, Grandl, Brigitte, Krapp, Stephan, Huber, Robert

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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor f... von Dossetter, Alexander G, Beeley, Howard, Bowyer, Jonathan, Cook, Calum R, Crawford, James J, Finlayson, Jonathan E, Heron, Nicola M, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Kenny, Peter W, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McGuire, Thomas M, Gutierrez, Pablo Morentin, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine

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Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Electronic supplementary inf... von McCoull, William, Augustin, Martin, Blake, Caroline, Ertan, Anne, Kilgour, Elaine, Krapp, Stephan, Moore, Jane E, Newcombe, Nicholas J, Packer, Martin J, Rees, Amanda, Revill, John, Scott, James S, Selmi, Nidhal, Gerhardt, Stefan, Ogg, Derek J, Steinbacher, Stefan, Whittamore, Paul R. O

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