Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS von Jovičić, Ana, Mertens, Jerome, Boeynaems, Steven, Bogaert, Elke, Chai, Noori, Yamada, Shizuka B, Paul, Joseph W, Sun, Shuying, Herdy, Joseph R, Bieri, Gregor, Kramer, Nicholas J, Gage, Fred H, Van Den Bosch, Ludo, Robberecht, Wim, Gitler, Aaron D

Volltext

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity von Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly, Shi, Yingxiao, Hertz, Nicholas T., Tessier-Lavigne, Marc, Ichida, Justin K., Bassik, Michael C., Gitler, Aaron D.

Volltext

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein von Dhungel, Nripesh, Eleuteri, Simona, Li, Ling-Bo, Kramer, Nicholas J, Chartron, Justin W, Spencer, Brian, Kosberg, Kori, Fields, Jerel Adam, Stafa, Klodjan, Adame, Anthony, Lashuel, Hilal, Frydman, Judith, Shen, Kang, Masliah, Eliezer, Gitler, Aaron D

Volltext

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD von Goodman, Lindsey D., Prudencio, Mercedes, Kramer, Nicholas J., Martinez-Ramirez, Luis F., Srinivasan, Ananth R., Lan, Matthews, Parisi, Michael J., Zhu, Yongqing, Chew, Jeannie, Cook, Casey N., Berson, Amit, Gitler, Aaron D., Petrucelli, Leonard, Bonini, Nancy M.

Volltext

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats von Yamada, Shizuka B., Gendron, Tania F., Niccoli, Teresa, Genuth, Naomi R., Grosely, Rosslyn, Shi, Yingxiao, Glaria, Idoia, Kramer, Nicholas J., Nakayama, Lisa, Fang, Shirleen, Dinger, Tai J. I., Thoeng, Annora, Rocha, Gabriel, Barna, Maria, Puglisi, Joseph D., Partridge, Linda, Ichida, Justin K., Isaacs, Adrian M., Petrucelli, Leonard, Gitler, Aaron D.

Volltext

Altered lymphopoiesis and immunodeficiency in miR-142 null mice von Kramer, Nicholas J., Wang, Wei-Le, Reyes, Estefany Y., Kumar, Bijender, Chen, Ching-Cheng, Ramakrishna, Chandran, Cantin, Edouard M., Vonderfecht, Steven L., Taganov, Konstantin D., Chau, Nelson, Boldin, Mark P.

Volltext

Reaction Discovery Using Neopentylene-Tethered Coupling Partners: Cycloisomerization/Oxidation of Electron-Deficient Dienynes von Kramer, Nicholas J, Hoang, Tung T, Dudley, Gregory B

Volltext

A versatile system to record cell-cell interactions von Tang, Rui, Murray, Christopher W, Linde, Ian L, Kramer, Nicholas J, Lyu, Zhonglin, Tsai, Min K, Chen, Leo C, Cai, Hongchen, Gitler, Aaron D, Engleman, Edgar, Lee, Wonjae, Winslow, Monte M

Volltext

Interception of the Bycroft–Gowland Intermediate in the Enzymatic Macrocyclization of Thiopeptides von Bogart, Jonathan W, Kramer, Nicholas J, Turlik, Aneta, Bleich, Rachel M, Catlin, Daniel S, Schroeder, Frank C, Nair, Satish K, Williamson, R. Thomas, Houk, K. N, Bowers, Albert A

Volltext

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons von Bieri, Gregor, Brahic, Michel, Bousset, Luc, Couthouis, Julien, Kramer, Nicholas J., Ma, Rosanna, Nakayama, Lisa, Monbureau, Marie, Defensor, Erwin, Schüle, Birgitt, Shamloo, Mehrdad, Melki, Ronald, Gitler, Aaron D.

Volltext

Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression von Kramer, Nicholas J., Prakash, Gyan, Isaac, R. Stefan, Choquet, Karine, Soto, Iliana, Petrova, Boryana, Merens, Hope E., Kanarek, Naama, Churchman, L. Stirling

Volltext

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts von Kramer, Nicholas J., Carlomagno, Yari, Zhang, Yong-Jie, Almeida, Sandra, Cook, Casey N., Gendron, Tania F., Prudencio, Mercedes, Van Blitterswijk, Marka, Belzil, Veronique, Couthouis, Julien, Paul, Joseph West, Goodman, Lindsey D., Daughrity, Lillian, Chew, Jeannie, Garrett, Aliesha, Pregent, Luc, Jansen-West, Karen, Tabassian, Lilia J., Rademakers, Rosa, Boylan, Kevin, Graff-Radford, Neill R., Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Boeve, Bradley F., Deng, Ning, Feng, Yanan, Cheng, Tzu-Hao, Dickson, Dennis W., Cohen, Stanley N., Bonini, Nancy M., Link, Christopher D., Gao, Fen-Biao, Petrucelli, Leonard, Gitler, Aaron D.

Volltext

Six-Step Synthesis of Alcyopterosin A, a Bioactive Illudalane Sesquiterpene with a gem-Dimethylcyclopentane Ring von Hoang, Tung T, Birepinte, Mélodie, Kramer, Nicholas J, Dudley, Gregory B

Volltext

Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis von Rice, Andrew J., Pelton, Jarrett M., Kramer, Nicholas J., Catlin, Daniel S., Nair, Satish K., Pogorelov, Taras V., Mitchell, Douglas A., Bowers, Albert A.

Volltext

Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein von Dhungel, Nripesh, Eleuteri, Simona, Li, Ling-Bo, Kramer, Nicholas J, Chartron, Justin W, Spencer, Brian, Kosberg, Kori, Fields, Jerel Adam, Stafa, Klodjan, Adame, Anthony, Lashuel, Hilal, Frydman, Judith, Shen, Kang, Masliah, Eliezer, Gitler, Aaron D

Volltext

Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD von Goodman, Lindsey D., Prudencio, Mercedes, Kramer, Nicholas J., Martinez-Ramirez, Luis F., Srinivasan, Ananth R., Lan, Matthews, Parisi, Michael J., Zhu, Yongqing, Chew, Jeannie, Cook, Casey N., Berson, Amit, Gitler, Aaron D., Petrucelli, Leonard, Bonini, Nancy M.

Volltext

Raise the Roof: Boosting the Efficacy of a Spinal Muscular Atrophy Therapy von Kramer, Nicholas J., Gitler, Aaron D.

Volltext

Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord von Street, Sarah E, Kramer, Nicholas J, Walsh, Paul L, Taylor-Blake, Bonnie, Yadav, Manisha C, King, Ian F, Vihko, Pirkko, Wightman, R Mark, Millán, José Luis, Zylka, Mark J

Volltext

Correction to “Six-Step Synthesis of Alcyopterosin A, a Bioactive Illudalane Sesquiterpene with a gem-Dimethylcyclopentane Ring” von Hoang, Tung T, Birepinte, Melodie, Kramer, Nicholas J, Dudley, Gregory B

Volltext

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure von Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

Volltext