Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects von Yamamoto, Syunsuke, Kosugi, Yohei, Hirabayashi, Hideki, Moriwaki, Toshiya

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Highly-sensitive simultaneous quantitation of glucosylsphingosine and galactosylsphingosine in human cerebrospinal fluid by liquid chromatography/tandem mass spectrometry von Matsumoto, Shin-ichi, Sato, Sho, Otake, Kentaro, Kosugi, Yohei

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Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement von Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide

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Discovery of a Novel and Brain-Penetrant O‑GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization von Tawada, Michiko, Fushimi, Makoto, Masuda, Kei, Sun, Huikai, Uchiyama, Noriko, Kosugi, Yohei, Lane, Weston, Tjhen, Richard, Endo, Satoshi, Koike, Tatsuki

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Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys von Iwasaki, Shinji, Yamamoto, Syunsuke, Sano, Noriyasu, Tohyama, Kimio, Kosugi, Yohei, Furuta, Atsutoshi, Hamada, Teruki, Igari, Tomoko, Fujioka, Yasushi, Hirabayashi, Hideki, Amano, Nobuyuki

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Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement von Suzuki, Atsushi, Kunugi, Akiyoshi, Tajima, Yasukazu, Suzuki, Noriko, Suzuki, Motohisa, Toyofuku, Masashi, Kuno, Haruhiko, Sogabe, Satoshi, Kosugi, Yohei, Awasaki, Yasuyuki, Kaku, Tomohiro, Kimura, Haruhide

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Prediction of Oral Pharmacokinetics Using a Combination of In Silico Descriptors and In Vitro ADME Properties von Kosugi, Yohei, Hosea, Natalie

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Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay von Kosugi, Yohei, Hosea, Natalie

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Human Brain Penetration Prediction Using Scaling Approach from Animal Machine Learning Models von Liu, Siyu, Kosugi, Yohei

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Quantitative assessment of coat‐hanger ribs detected on three‐dimensional ultrasound for prenatal diagnosis of Kagami‐Ogata syndrome von Kuriki, Akane, Hosoya, Satoshi, Ozawa, Katsusuke, Wada, Seiji, Kosugi, Yohei, Wada, Yuka S., Sekizawa, Akihiko, Miyazaki, Osamu, Kagami, Masayo, Sago, Haruhiko

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Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion von Kosugi, Yohei, Yamamoto, Syunsuke, Sano, Noriyasu, Furuta, Atsutoshi, Igari, Tomoko, Fujioka, Yasushi, Amano, Nobuyuki

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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic von Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu

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Prenatal diagnosis of congenital thyroid teratoma von Mori, Teizaburo, Kudo, Yumi, Kanamori, Yutaka, Tahara, Kazunori, Yamada, Yohei, Kutsukake, Mai, Fujita, Takuro, Miyake, Kazue, Fujino, Akihiro, Takahashi, Nozomi, Morimoto, Noriko, Kosugi, Yohei, Uehara, Yoji, Ito, Yushi, Miyazaki, Osamu, Sugibayashi, Rika, Ozawa, Katsusuke, Wada, Seiji, Sago, Haruhiko

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Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities von Sato, Sho, Tohyama, Kimio, Kosugi, Yohei

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Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentr... von Sato, Sho, Matsumiya, Kota, Tohyama, Kimio, Kosugi, Yohei

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Ensemble Machine Learning Approaches Based on Molecular Descriptors and Graph Convolutional Networks for Predicting the Efflux Activities of MDR1 and BCRP Transporters von Adachi, Asahi, Yamashita, Tomoki, Kanaya, Shigehiko, Kosugi, Yohei

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Quantitation and characterization of glucosylsphingosine in cerebrospinal fluid (CSF), plasma, and brain of monkey model with Gaucher disease von Sato, Sho, Matsumoto, Shin-Ichi, Kosugi, Yohei

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Congenital Langerhans cell histiocytosis diagnosed early due to blistering: A case report von Masuda, Hiroyuki, Iwasaki, Eriko, Kosugi, Yohei, Masuda, Yasuyuki, Sunada, Satoshi, Tokumasu, Satoko, Yoshizaki, Kanako, Sawada, Mariko, Hayashi, Tomohiro, Kubota, Masamichi, Takahashi, Akihito, Waki, Kenji

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Risk Assessment Using Cytochrome P450 Time-Dependent Inhibition Assays at Single Time and Concentration in the Early Stage of Drug Discovery von Kosaka, Mai, Kosugi, Yohei, Hirabayashi, Hideki

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Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist von Hoashi, Yasutaka, Takai, Takafumi, Kosugi, Yohei, Nakashima, Masato, Nakayama, Masaharu, Hirai, Keisuke, Uchikawa, Osamu, Koike, Tatsuki

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