Progressive multifocal leukoencephalopathy in a patient post allo-HCT successfully treated with JC virus specific donor lymphocytes von Steinhardt, M J, Wiercinska, E, Pham, M, Grigoleit, G U, Mazzoni, A, Da-Via, M, Zhou, X, Meckel, K, Nickel, K, Duell, J, Krummenast, F C, Kraus, S, Hopkinson, C, Weissbrich, B, Müllges, W, Stoll, G, Kortüm, K M, Einsele, H, Bonig, H, Rasche, L

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Dismal prognosis of Pneumocystis jirovecii pneumonia in patients with multiple myeloma von Riedhammer, C, Düll, J, Kestler, C, Kadel, S, Franz, J, Weis, P, Eisele, F, Zhou, X, Steinhardt, M, Scheller, L, Mersi, J, Waldschmidt, J. M, Einsele, H, Turnwald, D, Kortüm, K. M, Surat, G, Rasche, L

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Potential influence of concomitant chemotherapy on CXCR4 expression in receptor directed endoradiotherapy von Lapa, Constantin, Lückerath, Katharina, Kircher, Stefan, Hänscheid, Heribert, Grigoleit, Götz U., Rosenwald, Andreas, Stolzenburg, Antje, Kropf, Saskia, Einsele, Hermann, Wester, Hans‐Jürgen, Buck, Andreas K., Kortüm, Klaus M., Schirbel, Andreas

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Carfilzomib and the cardiorenal system in myeloma: an endothelial effect? von Rosenthal, A, Luthi, J, Belohlavek, M, Kortüm, K M, Mookadam, F, Mayo, A, Fonseca, R, Bergsagel, P L, Reeder, C B, Mikhael, J R, Stewart, A K

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Multiagent therapy with pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab (“Pom‐PAD‐Dara”) in relapsed/refractory multiple myeloma von Zhou, Xiang, Steinhardt, Maximilian J., Grathwohl, Denise, Meckel, Katharina, Nickel, Katharina, Leicht, Hans‐Benno, Krummenast, Franziska, Einsele, Hermann, Rasche, Leo, Kortüm, Klaus M.

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Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M3P) von Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S, Fonseca, R., Einsele, H., Stewart, A. K., Braggio, Esteban

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Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma von Stühmer, T, Zöllinger, A, Siegmund, D, Chatterjee, M, Grella, E, Knop, S, Kortüm, M, Unzicker, C, Jensen, M R, Quadt, C, Chène, P, Schoepfer, J, García-Echeverría, C, Einsele, H, Wajant, H, Bargou, R C

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PB1980: MULTIPLE MYELOMA: ADOPTING MRD BY NEXT GENERATION FLOW CYTOMETRY (NGF) AND FUNCTIONAL IMAGING GUIDED CONSOLIDATION INTO CLINICAL ROUTINE von Boeckle, D., Tabares, P., Zhou, X., Schimanski, S., Steinhardt, M. J., Bittrich, M., Seebacher, E., Ulbrich, M., Wilnit, A., Metz, C., Heidemeier, A., Bley, T., Werner, R., Buck, A., Einsele, H., Kortüm, M., Beilhack, A., Rasche, L.

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Cereblon binding molecules in multiple myeloma von Kortüm, K.M, Zhu, Y.X, Shi, C.X, Jedlowski, P, Stewart, A.K

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Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome von Barrio, S, Shanafelt, T D, Ojha, J, Chaffee, K G, Secreto, C, Kortüm, K M, Pathangey, S, Van-Dyke, D L, Slager, S L, Fonseca, R, Kay, N E, Braggio, E

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[11C]Methionine emerges as a new biomarker for tracking active myeloma lesions von Lapa, Constantin, Schreder, Martin, Lückerath, Katharina, Samnick, Samuel, Rudelius, Martina, Buck, Andreas K., Kortüm, Klaus M., Einsele, Hermann, Rosenwald, Andreas, Knop, Stefan

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P52 RISK STRATIFICATION COMBINING SKY92 GENE EXPRESSION PROFILING AND TRADITIONAL FISH IN MULTIPLE MYELOMA: THE FIRST PROSPECTIVE EVIDENCE IN THE R2‐ISS ERA von Zhou, X., Hofmann, A., Vogt, C., Nerreter, S., Teufel, E., Stanojkovska, E., Truger, M., Engel, B., Xiao, X., Eisele, F., Weis, P., Barcic, A., Peter, J., Riedhammer, C., Steinhardt, M. J., Hornburger, H., Han, S., Haertle, L., Munawar, U., Mersi, J., Haferlach, C., Einsele, H., Kortüm, K. M., Rasche, L.

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P45 HIGH‐DOSE CARFILZOMIB ACHIEVES SUPERIOR ANTI‐TUMOR ACTIVITY OVER LOW‐DOSE AND RECAPTURES RESPONSE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA RESISTANT TO LOW‐DOSE CARFILZOMIB BY C... von Zhou, X., Besse, A., Peter, J., Steinhardt, M. J., Vogt, C., Nerreter, S., Teufel, E., Stanojkovska, E., Xiao, X., Hornburger, H., Haertle, L., Mendez Lopez, M., Munawar, U., Riedel, A., Han, S., Maurits, E., Overkleeft, H. S., Florea, B., Einsele, H., Kortüm, K. M., Driessen, C., Besse, L., Rasche, L.

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S183: NOVEL COMBINATION IMMUNOTHERAPY FOR THE TREATMENT OF RELAPSED/REFRACTORY MULTIPLE MYELOMA: UPDATED PHASE 1B RESULTS FOR TALQUETAMAB (A GPRC5D X CD3 BISPECIFIC ANTIBODY) IN CO... von Donk, N. W., Bahlis, N., Mateos, M.‐V., Weisel, K., Dholaria, B., Garfall, A. L., Goldschmidt, H., Martin, T. G., Morillo, D., Reece, D. E., Hurd, D., Rodríguez‐Otero, P., Bhutani, M., D'Souza, A., Oriol, A., Askari, E., San‐Miguel, J. F., Kortüm, K. M., Vishwamitra, D., Xin Wang Lin, S., Prior, T. J., Vandenberk, L., Smit, M.‐A. D., Goldberg, J. D., Wäsch, R., Chari, A.

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MYC dysregulation in the progression of multiple myeloma von Misund, Kristine, Keane, Niamh, Stein, Caleb K., Asmann, Yan W., Day, Grady, Welsh, Seth, Van Wier, Scott A., Riggs, Daniel L., Ahmann, Greg, Chesi, Marta, Viswanatha, David S., Kumar, Shaji K., Dispenzieri, Angela, Gonzalez-Calle, Veronica, Kyle, Robert A., O’Dwyer, Michael, Rajkumar, S. Vincent, Kortüm, K. Martin, Keats, J. Jonathan, Fonseca, Rafael, Stewart, A. Keith, Kuehl, W. Michael, Braggio, Esteban, Bergsagel, P. Leif

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B06: SUBCUTANEOUS TALQUETAMAB IN COMBINATION WITH DARATUMUMAB IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): PHASE 1B RESULTS von Mateos, M, Hari, P, Bahlis, N, Chari, A, Donk, NWCJ, Dholaria, B, Garfall, AL, Goldschmidt, H, Kortüm, KM, Krishnan, A, Martin, T, Morillo, D, Oriol, A, Reece, D, Rodriguez, C, Rodríguez‐Otero, P, San‐Miguel, JF, Usmani, SZ, Verona, R, Lin, SXW, Prior, TJ, Wade, M, Weiss, B, Goldberg, JD, Askari, E

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PS1001 HACE1, A NOVEL TUMOR SUPPRESSOR GENE WHICH REGULATE THE RESPONSE OF VENETOCLAX, GANT61 AND NECROPTOSIS ACTIVATORS BY CONTROLLING C‐FLIP, GLI2 AND BCL2 GENES IN ACUTE MYELOID... von Garitano, A., Teufel, E., Kreckel, J., Nadine, R., Stühmer, T., Via, M. Da, Barrio, S., Nerreter, S., Haertle, L., Vogt, C., Düll, J., Rasche, L., Wajant, H., Rosenwald, A., Einsele, H., Kortüm, M.

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Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia von Ojha, Juhi, Secreto, Charla R., Rabe, Kari G., Van Dyke, Daniel L., Kortum, Klaus M., Slager, Susan L., Shanafelt, Tait D., Fonseca, Rafael, Kay, Neil E., Braggio, Esteban

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Targeted sequencing using a 47 gene multiple myeloma mutation panel (M3P) in ‐17p high risk disease von Kortüm, Klaus M., Langer, Christian, Monge, Jorge, Bruins, Laura, Egan, Jan B., Zhu, Yuan X., Shi, Chang Xin, Jedlowski, Patrick, Schmidt, Jessica, Ojha, Juhi, Bullinger, Lars, Liebisch, Peter, Kull, Miriam, Champion, Mia D., Van Wier, Scott, Ahmann, Gregory, Rasche, Leo, Knop, Stefan, Fonseca, Rafael, Einsele, Hermann, Stewart, A Keith, Braggio, Esteban

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Clinical and biological characteristics of myeloma patients influence response to elotuzumab combination therapy von Danhof, Sophia, Strifler, Susanne, Hose, Dorothea, Kortüm, Martin, Bittrich, Max, Hefner, Jochen, Einsele, Hermann, Knop, Stefan, Schreder, Martin

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