First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours von Ameratunga, Malaka, Braña, Irene, Bono, Petri, Postel-Vinay, Sophie, Plummer, Ruth, Aspegren, John, Korjamo, Timo, Snapir, Amir, de Bono, Johann S

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Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies von Zurth, Christian, Koskinen, Mikko, Fricke, Robert, Prien, Olaf, Korjamo, Timo, Graudenz, Kristina, Denner, Karsten, Bairlein, Michaela, von Bühler, Clemens-Jeremias, Wilkinson, Gary, Gieschen, Hille

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Analysis of Unstirred Water Layer in In Vitro Permeability Experiments von Korjamo, Timo, Heikkinen, Aki T., Mönkkönen, Jukka

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TRPA1: A Transducer and Amplifier of Pain and Inflammation von Koivisto, Ari, Chapman, Hugh, Jalava, Niina, Korjamo, Timo, Saarnilehto, Marja, Lindstedt, Ken, Pertovaara, Antti

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Transient Receptor Potential Ankyrin 1 Ion Channel Contributes to Guarding Pain and Mechanical Hypersensitivity in a Rat Model of Postoperative Pain von HONG WEI, KARIMAA, Mari, KORJAMO, Timo, KOIVISTO, Ari, PERTOVAARA, Antti

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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories von Hayeshi, Rose, Hilgendorf, Constanze, Artursson, Per, Augustijns, Patrick, Brodin, Birger, Dehertogh, Pascale, Fisher, Karen, Fossati, Lina, Hovenkamp, Egbert, Korjamo, Timo, Masungi, Chantal, Maubon, Nathalie, Mols, Raf, Müllertz, Anette, Mönkkönen, Jukka, O’Driscoll, Caitriona, Oppers-Tiemissen, H.M., Ragnarsson, Eva G.E., Rooseboom, Martijn, Ungell, Anna-Lena

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Use of comprehensive screening methods to detect selective human CAR activators von Küblbeck, Jenni, Laitinen, Tuomo, Jyrkkärinne, Johanna, Rousu, Timo, Tolonen, Ari, Abel, Tobias, Kortelainen, Tanja, Uusitalo, Jouko, Korjamo, Timo, Honkakoski, Paavo, Molnár, Ferdinand

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The Asymmetry of the Unstirred Water Layer in Permeability Experiments von Korjamo, Timo, Heikkinen, Aki T., Waltari, Pekka, Mönkkönen, Jukka

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Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates von Heikkinen, Aki T., Mönkkönen, Jukka, Korjamo, Timo

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Effects of Experimental Setup on the Apparent Concentration Dependency of Active Efflux Transport in in Vitro Cell Permeation Experiments von Heikkinen, Aki T, Korjamo, Timo, Lepikkö, Varpu, Mönkkönen, Jukka

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Predicting the effect of prandial stage and particle size on absorption of ODM-204 von Ojala, Krista, Schilderink, Ronald, Nykänen, Pirjo, van Veen, Bert, Malmström, Chira, Juppo, Anne, Korjamo, Timo

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Drug-drug interaction (DDI) of darolutamide with cytochrome P450 (CYP) and P-glycoprotein (P-gp) substrates: Results from clinical and in vitro studies von Zurth, Christian, Graudenz, Kristina, Denner, Karsten, Korjamo, Timo, Fricke, Robert, Wilkinson, Gary, Seitz, Friedeborg, Prien, Olaf

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How to stop disproportionation of a hydrochloride salt of a very weakly basic compound in a non-clinical suspension formulation von Ojala, Krista, Salmia, Jukka, Shevchenko, Anna, Ylikotila, Johanna, Korjamo, Timo, van Veen, Bert, Koistinen, Piritta, Malmström, Chira, Laakso, Sirpa, Bansal, Indu, Samiulla, D.S., Juppo, Anne

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5-HT6 receptor antagonists. Design, synthesis, and structure–activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines von Gałęzowski, Michał, Fabritius, Charles-Henry, Pesonen, Ullamari, Salo, Harri, Olszak-Płachta, Marta, Czerwińska, Klaudia, Adamczyk, Justyna, Król, Marcin, Prusis, Peteris, Sieprawska-Lupa, Magdalena, Mikulski, Maciej, Kuokkanen, Katja, Obuchowicz, Radosław, Korjamo, Timo, Jalava, Niina, Nikiforuk, Agnieszka, Nowak, Mateusz

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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans von Taavitsainen, Päivi, Prien, Olaf, Kähkönen, Marja, Niehues, Michael, Korjamo, Timo, Denner, Karsten, Nykänen, Pirjo, Vuorela, Annamari, Jungmann, Natalia A., von Bühler, Clemens-Jeremias, Koskinen, Mikko, Zurth, Christian, Gieschen, Hille

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ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity von Holmström, Tim H, Moilanen, Anu-Maarit, Ikonen, Tarja, Björkman, Mari L, Linnanen, Tero, Wohlfahrt, Gerd, Karlsson, Stefan, Oksala, Riikka, Korjamo, Timo, Samajdar, Susanta, Rajagopalan, Srinivasan, Chelur, Shekar, Narayanan, Kishore, Ramachandra, Raghuveer K, Mani, Jiju, Nair, Rashmi, Gowda, Nagaraj, Anthony, Thomas, Dhodheri, Samiulla, Mukherjee, Subhendu, Ujjinamatada, Ravi K, Srinivas, Nanduri, Ramachandra, Murali, Kallio, Pekka J

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Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions von Palmgrén, Joni J., Mönkkönen, Jukka, Korjamo, Timo, Hassinen, Anssi, Auriola, Seppo

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across... von Darwich, Adam S., Margolskee, Alison, Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson, Eva, Murphy, Dónal, Tannergren, Christer, Thörn, Helena, Yasin, Mohammed, Mazuir, Florent, Nicolas, Olivier, Ramusovic, Sergej, Xu, Christine, Pathak, Shriram M., Korjamo, Timo, Laru, Johanna, Malkki, Jussi, Pappinen, Sari, Tuunainen, Johanna, Dressman, Jennifer, Hansmann, Simone, Kostewicz, Edmund, He, Handan, Heimbach, Tycho, Wu, Fan, Hoft, Carolin, Pang, Yan, Bolger, Michael B., Huehn, Eva, Lukacova, Viera, Mullin, James M., Szeto, Ke X., Costales, Chester, Lin, Jian, McAllister, Mark, Modi, Sweta, Rotter, Charles, Varma, Manthena, Wong, Mei, Mitra, Amitava, Bevernage, Jan, Biewenga, Jeike, Van Peer, Achiel, Lloyd, Richard, Shardlow, Carole, Langguth, Peter, Mishenzon, Irina, Nguyen, Mai Anh, Brown, Jonathan, Lennernäs, Hans, Abrahamsson, Bertil

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Abstract 1753: Targeting cancer with selective cbp/p300 bromodomain inhibitors von Jaleel, Mahaboobi, Senaiar, Ramesh S., Abbineni, Chandrasekhar, Renukappa, Girish A., Mukherjee, Subhendu, Marappan, Sivapriya, Samiulla, DS, Aravind, AB, Kumar, Naveen R., Reddy, Venkata Siva N., Babu, Asha, Srinivas, Akhila P., Yadlapalli, Prasad, Tgore, Suraj, NR, Raghavendra, Naik, Chandranath D., Giri, Sanjeev, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Ravanti, laura, Myllymäki, Mikko, Wohlfahrt, Gerd, Mattila, Elina, Karlsson, Stefan, Björkman, Mari, Riikonen, Reetta, Ikonen, Tarja, Leimu, Laura, Mälmström, Chira, Korjamo, Timo, Moilanen, Anu, Ramachandra, Murali, Samajdar, Susanta

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5-HT 6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines von Gałęzowski, Michał, Fabritius, Charles-Henry, Pesonen, Ullamari, Salo, Harri, Olszak-Płachta, Marta, Czerwińska, Klaudia, Adamczyk, Justyna, Król, Marcin, Prusis, Peteris, Sieprawska-Lupa, Magdalena, Mikulski, Maciej, Kuokkanen, Katja, Obuchowicz, Radosław, Korjamo, Timo, Jalava, Niina, Nikiforuk, Agnieszka, Nowak, Mateusz

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